Telethonin variants found in Brugada syndrome, J‐wave pattern ECG, and ARVC reduce peak Nav1.5 currents in HEK‐293 cells

Background Telethonin (TCAP) is a Z‐disk protein that maintains cytoskeletal integrity and various signaling pathways in cardiomyocytes. TCAP is shown to modulate α‐subunit of the human cardiac sodium channel (hNav1.5) by direct interactions. Several TCAP variants are found in cardiomyopathies. We s...

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Veröffentlicht in:	Pacing and clinical electrophysiology 2020-08, Vol.43 (8), p.838-846
Hauptverfasser:	Turker, Isik, Makiyama, Takeru, Ueyama, Takeshi, Shimizu, Akihiko, Yamakawa, Masaru, Chen, Peng‐Sheng, Vatta, Matteo, Horie, Minoru, Ai, Tomohiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrhythmia arrhythmias ARVC Brugada Cardiomyocytes Cardiomyopathy Cytoskeleton EKG Heart J‐wave syndromes Phenotypes Sodium channels (voltage-gated) sudden cardiac death telethonin Ventricle
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