Selective C(sp3)−H Functionalization of Alkyl Esters with N‐/S‐/O‐Nucleophiles Using Perfluoroalkyl Iodide as Oxidant

An efficient transition metal‐free approach to achieve the selective cleavage of the α‐carbonyl C(sp3)−H bond in alkyl esters by using inexpensive, low‐toxic, and insensitive perfluoroalkyl iodide as the radical initiator has been developed. A variety of enamides, N‐heterocycles, amides, thiophenols...

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Veröffentlicht in:	Advanced synthesis & catalysis 2020-08, Vol.362 (16), p.3388-3394
Hauptverfasser:	Zhao, Shi‐Wen, Cai, Song‐Zhou, Wang, Mao‐Lin, Rao, Weidong, Xu, Haiyan, Zhang, Lei, Chu, Xue‐Qiang, Shen, Zhi‐Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	alkyl esters Amides C(sp3)−H functionalization Carbonyls CDC reaction Ductile-brittle transition Esters Hydrogen bonds Nucleophiles Oxidizing agents Perfluoroalkyl & polyfluoroalkyl substances perfluoroalkyl iodide Phenols Substrates transition metal-free Transition metals
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