Monoterpenes-containing PEGylated transfersomes for enhancing joint cavity drug delivery evidenced by CLSM and double-sited microdialysis

The synovial tissues are natural sites of drug delivery for the treatment of rheumatoid arthritis. Our previous study showed that mixed monoterpenes edge-activated PEGylated transfersomes (MMPTs) could significantly enhance the percutaneous absorption of sinomenine (SIN), an anti-inflammation drug....

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Veröffentlicht in:	Materials Science & Engineering C 2020-08, Vol.113, p.110929, Article 110929
Hauptverfasser:	Zheng, Hangsheng, Xu, Chang, Fei, Yarong, Wang, Juan, Yang, Mingshi, Fang, Li, Wei, Yinghui, Mu, Chaofeng, Sheng, Yunjie, Li, Fanzhu, Zhu, Jiazhen, Tao, Chenghao
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Area Under Curve Arthritis Blood Calorimetry Cavities Confocal microscopy Differential scanning calorimetry Drug Carriers - chemistry Drug delivery Drug delivery systems Elasticity Enthalpy Extrusion Holes Joint cavity Joints (anatomy) Joints - metabolism Liposomes Male Materials science Microdialysis Microscopy, Confocal Monoterpenes Monoterpenes - chemistry Morphinans - blood Morphinans - chemistry Morphinans - pharmacokinetics Pharmacokinetics Pharmacology Polyethylene Glycols - chemistry Rabbits Rats Rats, Sprague-Dawley Rheumatoid arthritis ROC Curve Scanning microscopy Sinomenine Skin Stratum corneum Thermodynamics Transfersomes Transition Temperature Transition temperatures
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