Novel PMMA bone cement nanocomposites containing magnesium phosphate nanosheets and hydroxyapatite nanofibers
Lack of bioactivity and monomer toxicity are limiting factors of polymethyl methacrylate (PMMA) bone cement in orthopedic applications. Herein, we address these shortcomings by proposing two-dimensional magnesium phosphate (MgP) nanosheets and hydroxyapatite (HA) nanofibers as novel fillers in PMMA...
Gespeichert in:
| Veröffentlicht in: | Materials Science & Engineering C 2020-04, Vol.109, p.110497, Article 110497 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 110497 |
| container_title | Materials Science & Engineering C |
| container_volume | 109 |
| creator | Phakatkar, Abhijit H. Shirdar, Mostafa Rezazadeh Qi, Mei-li Taheri, Mohammad Mahdi Narayanan, Surya Foroozan, Tara Sharifi-Asl, Soroosh Huang, Zhennan Agrawal, Megha Lu, Yu-peng Shahbazian-Yassar, Reza Shokuhfar, Tolou |
| description | Lack of bioactivity and monomer toxicity are limiting factors of polymethyl methacrylate (PMMA) bone cement in orthopedic applications. Herein, we address these shortcomings by proposing two-dimensional magnesium phosphate (MgP) nanosheets and hydroxyapatite (HA) nanofibers as novel fillers in PMMA bone cement nanocomposites. Two-dimensional MgP nanosheets and one-dimensional HA nanofibers were synthesized by tuning the crystallization of the sodium-magnesium-phosphate ternary system and hydrothermal homogeneous precipitation, respectively. We show that MgP nanosheets exhibit antibacterial properties against Escherichia coli (E. coli). In addition, HA nanofibers with high level of bioactivity are the proper choice to induce cell viability in the nanocomposite. Results indicate that the combination of both fillers can act as deformation locks enhancing the compressive strength of the nanocomposites. The synthesized nanocomposite possesses excellent bioactivity, mechanical properties, and cytocompatibility potentially opening new paradigm in the design of next generation bone cement composites.
•Development of PMMA composites with superior cytocompatibility, mechanical and antibacterial properties is a challenge.•2D MgP nanosheets and 1D HA nanofibers as nanofillers could be incorporated in the PMMA bone cement matrix.•PMMA-MgP-HA composites possess antibacterial attributes with enhanced cytocompatibility and mechanical properties.•Our findings indicate that the proposed composite can result in a paradigm shift in the design of existing bone cements. |
| doi_str_mv | 10.1016/j.msec.2019.110497 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2434499554</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0928493118313456</els_id><sourcerecordid>2434499554</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-8a959238feb7c10aab17ace02c916ec6665525bb50786a58f28baadad479c19f3</originalsourceid><addsrcrecordid>eNp9kMlKBDEQhoMoOi4v4EECnntM0lsCXkTcwO2g51CdrnYy2EmbZMR5e3uc0aOngqqv_qI-Qo45m3LGq7P5tI9opoJxNeWcFareIhMu6zwbO3ybTJgSMitUzvfIfoxzxiqZ12KX7OVCCKkqMSH9o__Ed_r88HBBG--QGuzRJerAeeP7wUebMFLjXQLrrHujPbw5jHbR02Hm4zCDhD90nCGmSMG1dLZsg_9awgDJbqadbTDEQ7LTwXvEo009IK_XVy-Xt9n9083d5cV9ZgohUyZBlUrkssOmNpwBNLwGg0wYxSs0VVWVpSibpmS1rKCUnZANQAttUSvDVZcfkNN17hD8xwJj0nO_CG48qUWRF4VSZVmMlFhTJvgYA3Z6CLaHsNSc6ZVhPdcrw3plWK8Nj0snm-hF02P7t_KrdATO1wCOD35aDDoai85gawOapFtv_8v_BpO_jvU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2434499554</pqid></control><display><type>article</type><title>Novel PMMA bone cement nanocomposites containing magnesium phosphate nanosheets and hydroxyapatite nanofibers</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Phakatkar, Abhijit H. ; Shirdar, Mostafa Rezazadeh ; Qi, Mei-li ; Taheri, Mohammad Mahdi ; Narayanan, Surya ; Foroozan, Tara ; Sharifi-Asl, Soroosh ; Huang, Zhennan ; Agrawal, Megha ; Lu, Yu-peng ; Shahbazian-Yassar, Reza ; Shokuhfar, Tolou</creator><creatorcontrib>Phakatkar, Abhijit H. ; Shirdar, Mostafa Rezazadeh ; Qi, Mei-li ; Taheri, Mohammad Mahdi ; Narayanan, Surya ; Foroozan, Tara ; Sharifi-Asl, Soroosh ; Huang, Zhennan ; Agrawal, Megha ; Lu, Yu-peng ; Shahbazian-Yassar, Reza ; Shokuhfar, Tolou</creatorcontrib><description>Lack of bioactivity and monomer toxicity are limiting factors of polymethyl methacrylate (PMMA) bone cement in orthopedic applications. Herein, we address these shortcomings by proposing two-dimensional magnesium phosphate (MgP) nanosheets and hydroxyapatite (HA) nanofibers as novel fillers in PMMA bone cement nanocomposites. Two-dimensional MgP nanosheets and one-dimensional HA nanofibers were synthesized by tuning the crystallization of the sodium-magnesium-phosphate ternary system and hydrothermal homogeneous precipitation, respectively. We show that MgP nanosheets exhibit antibacterial properties against Escherichia coli (E. coli). In addition, HA nanofibers with high level of bioactivity are the proper choice to induce cell viability in the nanocomposite. Results indicate that the combination of both fillers can act as deformation locks enhancing the compressive strength of the nanocomposites. The synthesized nanocomposite possesses excellent bioactivity, mechanical properties, and cytocompatibility potentially opening new paradigm in the design of next generation bone cement composites.
•Development of PMMA composites with superior cytocompatibility, mechanical and antibacterial properties is a challenge.•2D MgP nanosheets and 1D HA nanofibers as nanofillers could be incorporated in the PMMA bone cement matrix.•PMMA-MgP-HA composites possess antibacterial attributes with enhanced cytocompatibility and mechanical properties.•Our findings indicate that the proposed composite can result in a paradigm shift in the design of existing bone cements.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2019.110497</identifier><identifier>PMID: 32228962</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Antibacterial property ; Bioactivity ; Biocompatibility ; Biological activity ; Biomedical materials ; Bone cements ; Bone Cements - chemistry ; Bone implants ; Cell viability ; Cement ; Compressive Strength ; Crystallization ; Cytotoxicity ; Durapatite - chemistry ; E coli ; Escherichia coli - drug effects ; Fillers ; HA nanofibers ; Hydroxyapatite ; Limiting factors ; Magnesium ; Magnesium Compounds - chemistry ; Magnesium Compounds - pharmacology ; Magnesium phosphate ; Materials science ; Mechanical properties ; Nanocomposites ; Nanocomposites - chemistry ; Nanofibers ; Nanofibers - chemistry ; Nanosheets ; Orthopedics ; Phosphates - chemistry ; Phosphates - pharmacology ; PMMA nanocomposite ; Polymethyl methacrylate ; Polymethyl Methacrylate - chemistry ; Polymethylmethacrylate ; Synthesis ; Ternary systems ; Toxicity ; Two-dimensional magnesium phosphate nanosheets</subject><ispartof>Materials Science & Engineering C, 2020-04, Vol.109, p.110497, Article 110497</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Apr 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-8a959238feb7c10aab17ace02c916ec6665525bb50786a58f28baadad479c19f3</citedby><cites>FETCH-LOGICAL-c428t-8a959238feb7c10aab17ace02c916ec6665525bb50786a58f28baadad479c19f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0928493118313456$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32228962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Phakatkar, Abhijit H.</creatorcontrib><creatorcontrib>Shirdar, Mostafa Rezazadeh</creatorcontrib><creatorcontrib>Qi, Mei-li</creatorcontrib><creatorcontrib>Taheri, Mohammad Mahdi</creatorcontrib><creatorcontrib>Narayanan, Surya</creatorcontrib><creatorcontrib>Foroozan, Tara</creatorcontrib><creatorcontrib>Sharifi-Asl, Soroosh</creatorcontrib><creatorcontrib>Huang, Zhennan</creatorcontrib><creatorcontrib>Agrawal, Megha</creatorcontrib><creatorcontrib>Lu, Yu-peng</creatorcontrib><creatorcontrib>Shahbazian-Yassar, Reza</creatorcontrib><creatorcontrib>Shokuhfar, Tolou</creatorcontrib><title>Novel PMMA bone cement nanocomposites containing magnesium phosphate nanosheets and hydroxyapatite nanofibers</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Lack of bioactivity and monomer toxicity are limiting factors of polymethyl methacrylate (PMMA) bone cement in orthopedic applications. Herein, we address these shortcomings by proposing two-dimensional magnesium phosphate (MgP) nanosheets and hydroxyapatite (HA) nanofibers as novel fillers in PMMA bone cement nanocomposites. Two-dimensional MgP nanosheets and one-dimensional HA nanofibers were synthesized by tuning the crystallization of the sodium-magnesium-phosphate ternary system and hydrothermal homogeneous precipitation, respectively. We show that MgP nanosheets exhibit antibacterial properties against Escherichia coli (E. coli). In addition, HA nanofibers with high level of bioactivity are the proper choice to induce cell viability in the nanocomposite. Results indicate that the combination of both fillers can act as deformation locks enhancing the compressive strength of the nanocomposites. The synthesized nanocomposite possesses excellent bioactivity, mechanical properties, and cytocompatibility potentially opening new paradigm in the design of next generation bone cement composites.
•Development of PMMA composites with superior cytocompatibility, mechanical and antibacterial properties is a challenge.•2D MgP nanosheets and 1D HA nanofibers as nanofillers could be incorporated in the PMMA bone cement matrix.•PMMA-MgP-HA composites possess antibacterial attributes with enhanced cytocompatibility and mechanical properties.•Our findings indicate that the proposed composite can result in a paradigm shift in the design of existing bone cements.</description><subject>Antibacterial property</subject><subject>Bioactivity</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>Bone cements</subject><subject>Bone Cements - chemistry</subject><subject>Bone implants</subject><subject>Cell viability</subject><subject>Cement</subject><subject>Compressive Strength</subject><subject>Crystallization</subject><subject>Cytotoxicity</subject><subject>Durapatite - chemistry</subject><subject>E coli</subject><subject>Escherichia coli - drug effects</subject><subject>Fillers</subject><subject>HA nanofibers</subject><subject>Hydroxyapatite</subject><subject>Limiting factors</subject><subject>Magnesium</subject><subject>Magnesium Compounds - chemistry</subject><subject>Magnesium Compounds - pharmacology</subject><subject>Magnesium phosphate</subject><subject>Materials science</subject><subject>Mechanical properties</subject><subject>Nanocomposites</subject><subject>Nanocomposites - chemistry</subject><subject>Nanofibers</subject><subject>Nanofibers - chemistry</subject><subject>Nanosheets</subject><subject>Orthopedics</subject><subject>Phosphates - chemistry</subject><subject>Phosphates - pharmacology</subject><subject>PMMA nanocomposite</subject><subject>Polymethyl methacrylate</subject><subject>Polymethyl Methacrylate - chemistry</subject><subject>Polymethylmethacrylate</subject><subject>Synthesis</subject><subject>Ternary systems</subject><subject>Toxicity</subject><subject>Two-dimensional magnesium phosphate nanosheets</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlKBDEQhoMoOi4v4EECnntM0lsCXkTcwO2g51CdrnYy2EmbZMR5e3uc0aOngqqv_qI-Qo45m3LGq7P5tI9opoJxNeWcFareIhMu6zwbO3ybTJgSMitUzvfIfoxzxiqZ12KX7OVCCKkqMSH9o__Ed_r88HBBG--QGuzRJerAeeP7wUebMFLjXQLrrHujPbw5jHbR02Hm4zCDhD90nCGmSMG1dLZsg_9awgDJbqadbTDEQ7LTwXvEo009IK_XVy-Xt9n9083d5cV9ZgohUyZBlUrkssOmNpwBNLwGg0wYxSs0VVWVpSibpmS1rKCUnZANQAttUSvDVZcfkNN17hD8xwJj0nO_CG48qUWRF4VSZVmMlFhTJvgYA3Z6CLaHsNSc6ZVhPdcrw3plWK8Nj0snm-hF02P7t_KrdATO1wCOD35aDDoai85gawOapFtv_8v_BpO_jvU</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Phakatkar, Abhijit H.</creator><creator>Shirdar, Mostafa Rezazadeh</creator><creator>Qi, Mei-li</creator><creator>Taheri, Mohammad Mahdi</creator><creator>Narayanan, Surya</creator><creator>Foroozan, Tara</creator><creator>Sharifi-Asl, Soroosh</creator><creator>Huang, Zhennan</creator><creator>Agrawal, Megha</creator><creator>Lu, Yu-peng</creator><creator>Shahbazian-Yassar, Reza</creator><creator>Shokuhfar, Tolou</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>202004</creationdate><title>Novel PMMA bone cement nanocomposites containing magnesium phosphate nanosheets and hydroxyapatite nanofibers</title><author>Phakatkar, Abhijit H. ; Shirdar, Mostafa Rezazadeh ; Qi, Mei-li ; Taheri, Mohammad Mahdi ; Narayanan, Surya ; Foroozan, Tara ; Sharifi-Asl, Soroosh ; Huang, Zhennan ; Agrawal, Megha ; Lu, Yu-peng ; Shahbazian-Yassar, Reza ; Shokuhfar, Tolou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-8a959238feb7c10aab17ace02c916ec6665525bb50786a58f28baadad479c19f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibacterial property</topic><topic>Bioactivity</topic><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Biomedical materials</topic><topic>Bone cements</topic><topic>Bone Cements - chemistry</topic><topic>Bone implants</topic><topic>Cell viability</topic><topic>Cement</topic><topic>Compressive Strength</topic><topic>Crystallization</topic><topic>Cytotoxicity</topic><topic>Durapatite - chemistry</topic><topic>E coli</topic><topic>Escherichia coli - drug effects</topic><topic>Fillers</topic><topic>HA nanofibers</topic><topic>Hydroxyapatite</topic><topic>Limiting factors</topic><topic>Magnesium</topic><topic>Magnesium Compounds - chemistry</topic><topic>Magnesium Compounds - pharmacology</topic><topic>Magnesium phosphate</topic><topic>Materials science</topic><topic>Mechanical properties</topic><topic>Nanocomposites</topic><topic>Nanocomposites - chemistry</topic><topic>Nanofibers</topic><topic>Nanofibers - chemistry</topic><topic>Nanosheets</topic><topic>Orthopedics</topic><topic>Phosphates - chemistry</topic><topic>Phosphates - pharmacology</topic><topic>PMMA nanocomposite</topic><topic>Polymethyl methacrylate</topic><topic>Polymethyl Methacrylate - chemistry</topic><topic>Polymethylmethacrylate</topic><topic>Synthesis</topic><topic>Ternary systems</topic><topic>Toxicity</topic><topic>Two-dimensional magnesium phosphate nanosheets</topic><toplevel>online_resources</toplevel><creatorcontrib>Phakatkar, Abhijit H.</creatorcontrib><creatorcontrib>Shirdar, Mostafa Rezazadeh</creatorcontrib><creatorcontrib>Qi, Mei-li</creatorcontrib><creatorcontrib>Taheri, Mohammad Mahdi</creatorcontrib><creatorcontrib>Narayanan, Surya</creatorcontrib><creatorcontrib>Foroozan, Tara</creatorcontrib><creatorcontrib>Sharifi-Asl, Soroosh</creatorcontrib><creatorcontrib>Huang, Zhennan</creatorcontrib><creatorcontrib>Agrawal, Megha</creatorcontrib><creatorcontrib>Lu, Yu-peng</creatorcontrib><creatorcontrib>Shahbazian-Yassar, Reza</creatorcontrib><creatorcontrib>Shokuhfar, Tolou</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phakatkar, Abhijit H.</au><au>Shirdar, Mostafa Rezazadeh</au><au>Qi, Mei-li</au><au>Taheri, Mohammad Mahdi</au><au>Narayanan, Surya</au><au>Foroozan, Tara</au><au>Sharifi-Asl, Soroosh</au><au>Huang, Zhennan</au><au>Agrawal, Megha</au><au>Lu, Yu-peng</au><au>Shahbazian-Yassar, Reza</au><au>Shokuhfar, Tolou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel PMMA bone cement nanocomposites containing magnesium phosphate nanosheets and hydroxyapatite nanofibers</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2020-04</date><risdate>2020</risdate><volume>109</volume><spage>110497</spage><pages>110497-</pages><artnum>110497</artnum><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Lack of bioactivity and monomer toxicity are limiting factors of polymethyl methacrylate (PMMA) bone cement in orthopedic applications. Herein, we address these shortcomings by proposing two-dimensional magnesium phosphate (MgP) nanosheets and hydroxyapatite (HA) nanofibers as novel fillers in PMMA bone cement nanocomposites. Two-dimensional MgP nanosheets and one-dimensional HA nanofibers were synthesized by tuning the crystallization of the sodium-magnesium-phosphate ternary system and hydrothermal homogeneous precipitation, respectively. We show that MgP nanosheets exhibit antibacterial properties against Escherichia coli (E. coli). In addition, HA nanofibers with high level of bioactivity are the proper choice to induce cell viability in the nanocomposite. Results indicate that the combination of both fillers can act as deformation locks enhancing the compressive strength of the nanocomposites. The synthesized nanocomposite possesses excellent bioactivity, mechanical properties, and cytocompatibility potentially opening new paradigm in the design of next generation bone cement composites.
•Development of PMMA composites with superior cytocompatibility, mechanical and antibacterial properties is a challenge.•2D MgP nanosheets and 1D HA nanofibers as nanofillers could be incorporated in the PMMA bone cement matrix.•PMMA-MgP-HA composites possess antibacterial attributes with enhanced cytocompatibility and mechanical properties.•Our findings indicate that the proposed composite can result in a paradigm shift in the design of existing bone cements.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32228962</pmid><doi>10.1016/j.msec.2019.110497</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0928-4931 |
| ispartof | Materials Science & Engineering C, 2020-04, Vol.109, p.110497, Article 110497 |
| issn | 0928-4931 1873-0191 |
| language | eng |
| recordid | cdi_proquest_journals_2434499554 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antibacterial property Bioactivity Biocompatibility Biological activity Biomedical materials Bone cements Bone Cements - chemistry Bone implants Cell viability Cement Compressive Strength Crystallization Cytotoxicity Durapatite - chemistry E coli Escherichia coli - drug effects Fillers HA nanofibers Hydroxyapatite Limiting factors Magnesium Magnesium Compounds - chemistry Magnesium Compounds - pharmacology Magnesium phosphate Materials science Mechanical properties Nanocomposites Nanocomposites - chemistry Nanofibers Nanofibers - chemistry Nanosheets Orthopedics Phosphates - chemistry Phosphates - pharmacology PMMA nanocomposite Polymethyl methacrylate Polymethyl Methacrylate - chemistry Polymethylmethacrylate Synthesis Ternary systems Toxicity Two-dimensional magnesium phosphate nanosheets |
| title | Novel PMMA bone cement nanocomposites containing magnesium phosphate nanosheets and hydroxyapatite nanofibers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T16%3A04%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Novel%20PMMA%20bone%20cement%20nanocomposites%20containing%20magnesium%20phosphate%20nanosheets%20and%20hydroxyapatite%20nanofibers&rft.jtitle=Materials%20Science%20&%20Engineering%20C&rft.au=Phakatkar,%20Abhijit%20H.&rft.date=2020-04&rft.volume=109&rft.spage=110497&rft.pages=110497-&rft.artnum=110497&rft.issn=0928-4931&rft.eissn=1873-0191&rft_id=info:doi/10.1016/j.msec.2019.110497&rft_dat=%3Cproquest_cross%3E2434499554%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2434499554&rft_id=info:pmid/32228962&rft_els_id=S0928493118313456&rfr_iscdi=true |