Effect of serum albumin level on hospital outcomes in out-of-hospital cardiac arrest
Background: Background: Serum albumin has been known as a strong predictive value of mortality in various disease conditions, severe burns, major surgeries, stroke, myocardial infarction, etc. But little is known for the effect of serum albumin level on out-of-hospital cardiac arrest patients. Objec...
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| Veröffentlicht in: | Hong Kong journal of emergency medicine 2020-09, Vol.27 (5), p.293-299 |
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| creator | Yoon, Hanna Song, Kyoung Jun Shin, Sang Do Ro, Young Sun Hong, Ki Jeong Park, Jeong Ho |
| description | Background: Background: Serum albumin has been known as a strong predictive value of mortality in various disease conditions, severe burns, major surgeries, stroke, myocardial infarction, etc. But little is known for the effect of serum albumin level on out-of-hospital cardiac arrest patients.
Objectives: This study aimed to investigate the effect of serum albumin level on the outcome of out of hospital cardiac arrest.
Methods: This study was a prospective hospital-based patient cohort study, conducted during January to December 2014 at 27 emergency departments in Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance project. The albumin was measured immediately after arrival to the emergency department during cardiopulmonary resuscitation, and albumin was categorized into two groups, group < 3.5 g/dL group and ⩾ 3.5 g/dL group. The primary outcome was a good neurological recovery at discharge (cerebral performance category scale 1 or 2). Multivariable logistic regression was used for adjusting for confounders.
Results: During the study period, 1616 out-of-hospital cardiac arrest patients with presumed cardiac etiology were enrolled, and the total of 1013 patients were analyzed in this study. A total 452 (44.6%) patients had serum albumin level less than 3.5 g/dL. The serum albumin ⩾ 3.5 g/dL group showed better neurological outcomes than the serum albumin < 3.5 g/dL group: 18.5% versus 4.0%, and ⩾ 3.5 g/dL group had higher survival discharge rates than the < 3.5 g/dL group: 23.9% versus 9.1% (p < 0.01). After adjusting for potential covariates, patients with serum albumin ⩾ 3.5 g/dL had a higher odds of good neurological recovery (adjusted odds ratio: 2.94 (95% confidence interval: [1.57, 5.49])), and higher survival to discharge (adjusted odds ratio: 1.74 (95% confidence interval: [1.10, 2.76])).
Conclusion: Low serum albumin levels are associated with a worse neurologic outcome in patients with out-of-hospital cardiac arrest. |
| doi_str_mv | 10.1177/1024907919849786 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2434437743</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><informt_id>10.3316/informit.384006923286696</informt_id><sage_id>10.1177_1024907919849786</sage_id><sourcerecordid>2434437743</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4820-dbce3d175ac0a77c68ace219dcbec0326c54b9324911a71629bbfcde31ec75893</originalsourceid><addsrcrecordid>eNqFkc1LxDAQxYMouKh3jwXP1Xw1aY66rN_gRcFbSKepm6Vt1qRV_O_NWnHBg-aSgd978yYThI4JPiVEyjOCKVdYKqJKrmQpdtCMMqzygmO5i2YbnG_4PjqKcYU3R-JC4Rl6XDSNhSHzTRZtGLvMtNXYuT5r7ZttM99nSx_XbjCpHgfwnY1ZoqnOfZP_MDChdgYyE4KNwyHaa0wb7dH3fYCeLheP8-v8_uHqZn5-nwMvKc7rCiyriSwMYCMliNKApUTVUFnAjAooeKVYehohRhJBVVU1UFtGLMiiVOwAnUx918G_jilYr_wY-hSpKWecMyk5Syo8qSD4GINt9Dq4zoQPTbDerE__Xl-yqMny7lr78a9eX9_d0otLTNLSkzefvNG82O1Af2Q9T_rQuUGDb9v0H873cWWGqKM1AZba9Y3_4j686No7baqvlowRsYWs5BgLRRkthVCCfQI0Kp6P</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2434437743</pqid></control><display><type>article</type><title>Effect of serum albumin level on hospital outcomes in out-of-hospital cardiac arrest</title><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>Alma/SFX Local Collection</source><creator>Yoon, Hanna ; Song, Kyoung Jun ; Shin, Sang Do ; Ro, Young Sun ; Hong, Ki Jeong ; Park, Jeong Ho</creator><creatorcontrib>Yoon, Hanna ; Song, Kyoung Jun ; Shin, Sang Do ; Ro, Young Sun ; Hong, Ki Jeong ; Park, Jeong Ho</creatorcontrib><description>Background: Background: Serum albumin has been known as a strong predictive value of mortality in various disease conditions, severe burns, major surgeries, stroke, myocardial infarction, etc. But little is known for the effect of serum albumin level on out-of-hospital cardiac arrest patients.
Objectives: This study aimed to investigate the effect of serum albumin level on the outcome of out of hospital cardiac arrest.
Methods: This study was a prospective hospital-based patient cohort study, conducted during January to December 2014 at 27 emergency departments in Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance project. The albumin was measured immediately after arrival to the emergency department during cardiopulmonary resuscitation, and albumin was categorized into two groups, group < 3.5 g/dL group and ⩾ 3.5 g/dL group. The primary outcome was a good neurological recovery at discharge (cerebral performance category scale 1 or 2). Multivariable logistic regression was used for adjusting for confounders.
Results: During the study period, 1616 out-of-hospital cardiac arrest patients with presumed cardiac etiology were enrolled, and the total of 1013 patients were analyzed in this study. A total 452 (44.6%) patients had serum albumin level less than 3.5 g/dL. The serum albumin ⩾ 3.5 g/dL group showed better neurological outcomes than the serum albumin < 3.5 g/dL group: 18.5% versus 4.0%, and ⩾ 3.5 g/dL group had higher survival discharge rates than the < 3.5 g/dL group: 23.9% versus 9.1% (p < 0.01). After adjusting for potential covariates, patients with serum albumin ⩾ 3.5 g/dL had a higher odds of good neurological recovery (adjusted odds ratio: 2.94 (95% confidence interval: [1.57, 5.49])), and higher survival to discharge (adjusted odds ratio: 1.74 (95% confidence interval: [1.10, 2.76])).
Conclusion: Low serum albumin levels are associated with a worse neurologic outcome in patients with out-of-hospital cardiac arrest.</description><identifier>ISSN: 1024-9079</identifier><identifier>EISSN: 2309-5407</identifier><identifier>DOI: 10.1177/1024907919849786</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>albumin ; Cardiac arrest ; Care ; Confidence intervals ; CPR (First aid) ; Diagnosis ; Emergency medical care ; Heart attacks ; Hospital care ; Mortality ; Myocardial infarction ; neurologic outcomes ; Out‐of‐hospital cardiac arrest ; Patients ; Physiological effect ; Serum albumin ; Treatment</subject><ispartof>Hong Kong journal of emergency medicine, 2020-09, Vol.27 (5), p.293-299</ispartof><rights>The Author(s) 2019</rights><rights>The Authors</rights><rights>The Author(s) 2019. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4820-dbce3d175ac0a77c68ace219dcbec0326c54b9324911a71629bbfcde31ec75893</citedby><cites>FETCH-LOGICAL-c4820-dbce3d175ac0a77c68ace219dcbec0326c54b9324911a71629bbfcde31ec75893</cites><orcidid>0000-0002-0027-6352</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1177%2F1024907919849786$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1177%2F1024907919849786$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,11562,27924,27925,46052,46476</link.rule.ids></links><search><creatorcontrib>Yoon, Hanna</creatorcontrib><creatorcontrib>Song, Kyoung Jun</creatorcontrib><creatorcontrib>Shin, Sang Do</creatorcontrib><creatorcontrib>Ro, Young Sun</creatorcontrib><creatorcontrib>Hong, Ki Jeong</creatorcontrib><creatorcontrib>Park, Jeong Ho</creatorcontrib><title>Effect of serum albumin level on hospital outcomes in out-of-hospital cardiac arrest</title><title>Hong Kong journal of emergency medicine</title><description>Background: Background: Serum albumin has been known as a strong predictive value of mortality in various disease conditions, severe burns, major surgeries, stroke, myocardial infarction, etc. But little is known for the effect of serum albumin level on out-of-hospital cardiac arrest patients.
Objectives: This study aimed to investigate the effect of serum albumin level on the outcome of out of hospital cardiac arrest.
Methods: This study was a prospective hospital-based patient cohort study, conducted during January to December 2014 at 27 emergency departments in Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance project. The albumin was measured immediately after arrival to the emergency department during cardiopulmonary resuscitation, and albumin was categorized into two groups, group < 3.5 g/dL group and ⩾ 3.5 g/dL group. The primary outcome was a good neurological recovery at discharge (cerebral performance category scale 1 or 2). Multivariable logistic regression was used for adjusting for confounders.
Results: During the study period, 1616 out-of-hospital cardiac arrest patients with presumed cardiac etiology were enrolled, and the total of 1013 patients were analyzed in this study. A total 452 (44.6%) patients had serum albumin level less than 3.5 g/dL. The serum albumin ⩾ 3.5 g/dL group showed better neurological outcomes than the serum albumin < 3.5 g/dL group: 18.5% versus 4.0%, and ⩾ 3.5 g/dL group had higher survival discharge rates than the < 3.5 g/dL group: 23.9% versus 9.1% (p < 0.01). After adjusting for potential covariates, patients with serum albumin ⩾ 3.5 g/dL had a higher odds of good neurological recovery (adjusted odds ratio: 2.94 (95% confidence interval: [1.57, 5.49])), and higher survival to discharge (adjusted odds ratio: 1.74 (95% confidence interval: [1.10, 2.76])).
Conclusion: Low serum albumin levels are associated with a worse neurologic outcome in patients with out-of-hospital cardiac arrest.</description><subject>albumin</subject><subject>Cardiac arrest</subject><subject>Care</subject><subject>Confidence intervals</subject><subject>CPR (First aid)</subject><subject>Diagnosis</subject><subject>Emergency medical care</subject><subject>Heart attacks</subject><subject>Hospital care</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>neurologic outcomes</subject><subject>Out‐of‐hospital cardiac arrest</subject><subject>Patients</subject><subject>Physiological effect</subject><subject>Serum albumin</subject><subject>Treatment</subject><issn>1024-9079</issn><issn>2309-5407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkc1LxDAQxYMouKh3jwXP1Xw1aY66rN_gRcFbSKepm6Vt1qRV_O_NWnHBg-aSgd978yYThI4JPiVEyjOCKVdYKqJKrmQpdtCMMqzygmO5i2YbnG_4PjqKcYU3R-JC4Rl6XDSNhSHzTRZtGLvMtNXYuT5r7ZttM99nSx_XbjCpHgfwnY1ZoqnOfZP_MDChdgYyE4KNwyHaa0wb7dH3fYCeLheP8-v8_uHqZn5-nwMvKc7rCiyriSwMYCMliNKApUTVUFnAjAooeKVYehohRhJBVVU1UFtGLMiiVOwAnUx918G_jilYr_wY-hSpKWecMyk5Syo8qSD4GINt9Dq4zoQPTbDerE__Xl-yqMny7lr78a9eX9_d0otLTNLSkzefvNG82O1Af2Q9T_rQuUGDb9v0H873cWWGqKM1AZba9Y3_4j686No7baqvlowRsYWs5BgLRRkthVCCfQI0Kp6P</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Yoon, Hanna</creator><creator>Song, Kyoung Jun</creator><creator>Shin, Sang Do</creator><creator>Ro, Young Sun</creator><creator>Hong, Ki Jeong</creator><creator>Park, Jeong Ho</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-0027-6352</orcidid></search><sort><creationdate>20200901</creationdate><title>Effect of serum albumin level on hospital outcomes in out-of-hospital cardiac arrest</title><author>Yoon, Hanna ; Song, Kyoung Jun ; Shin, Sang Do ; Ro, Young Sun ; Hong, Ki Jeong ; Park, Jeong Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4820-dbce3d175ac0a77c68ace219dcbec0326c54b9324911a71629bbfcde31ec75893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>albumin</topic><topic>Cardiac arrest</topic><topic>Care</topic><topic>Confidence intervals</topic><topic>CPR (First aid)</topic><topic>Diagnosis</topic><topic>Emergency medical care</topic><topic>Heart attacks</topic><topic>Hospital care</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>neurologic outcomes</topic><topic>Out‐of‐hospital cardiac arrest</topic><topic>Patients</topic><topic>Physiological effect</topic><topic>Serum albumin</topic><topic>Treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, Hanna</creatorcontrib><creatorcontrib>Song, Kyoung Jun</creatorcontrib><creatorcontrib>Shin, Sang Do</creatorcontrib><creatorcontrib>Ro, Young Sun</creatorcontrib><creatorcontrib>Hong, Ki Jeong</creatorcontrib><creatorcontrib>Park, Jeong Ho</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library Free Content</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Hong Kong journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, Hanna</au><au>Song, Kyoung Jun</au><au>Shin, Sang Do</au><au>Ro, Young Sun</au><au>Hong, Ki Jeong</au><au>Park, Jeong Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of serum albumin level on hospital outcomes in out-of-hospital cardiac arrest</atitle><jtitle>Hong Kong journal of emergency medicine</jtitle><date>2020-09-01</date><risdate>2020</risdate><volume>27</volume><issue>5</issue><spage>293</spage><epage>299</epage><pages>293-299</pages><issn>1024-9079</issn><eissn>2309-5407</eissn><abstract>Background: Background: Serum albumin has been known as a strong predictive value of mortality in various disease conditions, severe burns, major surgeries, stroke, myocardial infarction, etc. But little is known for the effect of serum albumin level on out-of-hospital cardiac arrest patients.
Objectives: This study aimed to investigate the effect of serum albumin level on the outcome of out of hospital cardiac arrest.
Methods: This study was a prospective hospital-based patient cohort study, conducted during January to December 2014 at 27 emergency departments in Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance project. The albumin was measured immediately after arrival to the emergency department during cardiopulmonary resuscitation, and albumin was categorized into two groups, group < 3.5 g/dL group and ⩾ 3.5 g/dL group. The primary outcome was a good neurological recovery at discharge (cerebral performance category scale 1 or 2). Multivariable logistic regression was used for adjusting for confounders.
Results: During the study period, 1616 out-of-hospital cardiac arrest patients with presumed cardiac etiology were enrolled, and the total of 1013 patients were analyzed in this study. A total 452 (44.6%) patients had serum albumin level less than 3.5 g/dL. The serum albumin ⩾ 3.5 g/dL group showed better neurological outcomes than the serum albumin < 3.5 g/dL group: 18.5% versus 4.0%, and ⩾ 3.5 g/dL group had higher survival discharge rates than the < 3.5 g/dL group: 23.9% versus 9.1% (p < 0.01). After adjusting for potential covariates, patients with serum albumin ⩾ 3.5 g/dL had a higher odds of good neurological recovery (adjusted odds ratio: 2.94 (95% confidence interval: [1.57, 5.49])), and higher survival to discharge (adjusted odds ratio: 1.74 (95% confidence interval: [1.10, 2.76])).
Conclusion: Low serum albumin levels are associated with a worse neurologic outcome in patients with out-of-hospital cardiac arrest.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><doi>10.1177/1024907919849786</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0027-6352</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | albumin Cardiac arrest Care Confidence intervals CPR (First aid) Diagnosis Emergency medical care Heart attacks Hospital care Mortality Myocardial infarction neurologic outcomes Out‐of‐hospital cardiac arrest Patients Physiological effect Serum albumin Treatment |
| title | Effect of serum albumin level on hospital outcomes in out-of-hospital cardiac arrest |
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