Protective effect of adenosine triphosphate against sunitinib-related skin damage in rats

Cutaneous side effects associated with sunitinib use are a major problem in patients receiving cancer treatment. The aim of this study was to investigate the protective effect of adenosine triphosphate (ATP) against possible skin damage resulting from sunitinib use in rats. Thirty Albino Winstar rat...

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Veröffentlicht in:	Human & experimental toxicology 2020-12, Vol.39 (12), p.1737-1746
Hauptverfasser:	Yıldırım, N, Karatas, A, Cengiz, M, Onalan, E, Yazıcı, GN, Sunar, M, Mammadov, R, Coban, A, Suleyman, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Adenosine Triphosphate - pharmacology Adenosine Triphosphate - therapeutic use Animals Antineoplastic Agents - toxicity Antioxidants ATP Damage prevention Edema Epithelium Glutathione Glutathione - metabolism Inflammation Inhibitor drugs Keratin Male Malondialdehyde Malondialdehyde - metabolism Oral administration Oxidants Oxidative stress Oxidative Stress - drug effects Oxidizing agents Plugs Protective Agents - pharmacology Protective Agents - therapeutic use Rats, Wistar Side effects Skin Skin - drug effects Skin - injuries Skin - metabolism Skin - pathology Skin Diseases - chemically induced Skin Diseases - drug therapy Skin Diseases - metabolism Skin Diseases - pathology Sodium chloride Sunitinib - toxicity Targeted cancer therapy
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