METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

ObjectiveN6-methyladenosine (m6A) RNA methylation and its associated methyltransferase METTL3 are involved in tumour initiation and progression via the regulation of RNA function. This study explored the biological function and clinical significance of METTL3 in gastric cancer (GC).DesignThe prognos...

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Veröffentlicht in:	Gut 2020-07, Vol.69 (7), p.1193-1205
Hauptverfasser:	Wang, Qiang, Chen, Chen, Ding, Qingqing, Zhao, Yan, Wang, Zhangding, Chen, Junjie, Jiang, Zerun, Zhang, Yan, Xu, Guifang, Zhang, Jingjing, Zhou, Jianwei, Sun, Beicheng, Zou, Xiaoping, Wang, Shouyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Angiogenesis Bioinformatics Biomarkers DNA microarrays Gastric cancer Genomes Glycolysis Liver Lymphatic system Medical prognosis Metabolism Metastases Metastasis Methyltransferase METTL3 mRNA stability N6-methyladenosine Regression analysis RNA modification RNA-protein interactions Stomach Transcription Tumors
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