miR-541 potentiates the response of human hepatocellular carcinoma to sorafenib treatment by inhibiting autophagy

ObjectiveAutophagy participates in the progression of hepatocellular carcinoma (HCC) and the resistance of HCC cells to sorafenib. We investigated the feasibility of sensitising HCC cells to sorafenib by modulating miR-541-initiated microRNA-autophagy axis.DesignGain- and loss-of-function assays wer...

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Veröffentlicht in:	Gut 2020-07, Vol.69 (7), p.1309-1321
Hauptverfasser:	Xu, Wen-Ping, Liu, Jin-Pei, Feng, Ji-Feng, Zhu, Chang-Peng, Yang, Yuan, Zhou, Wei-Ping, Ding, Jin, Huang, Chen-Kai, Cui, Ya-Lu, Ding, Chen-Hong, Zhang, Xin, Lu, Bin, Xie, Wei-Fen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Antineoplastic Agents - pharmacology Autophagy Autophagy - drug effects Binding sites Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Confocal microscopy Drug resistance Drug Resistance, Neoplasm Feasibility Studies Gene expression Genetic engineering Genomics Hepatocellular carcinoma Hepatology Humans Hypoxia Lethality Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology Medical prognosis Metastases Metastasis Mice MicroRNAs MicroRNAs - metabolism Microscopy miRNA molecular carcinogenesis Neoplasm Recurrence, Local Phagocytosis Phenotype Phenotypes Proteins Sorafenib - pharmacology Targeted cancer therapy Transmission electron microscopy Tumors Western blotting Xenografts
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