The synthesis of new acyclic analogs of 3-phenacyluridine and comparative evaluation of their in vivo biological activity

New structural analogs of 3-phenacyluridine were obtained as a result of N (3)-alkylation of 1-(2-acetoxyethyl)- and 1-(2-acetoxyethoxymethyl) uracil. Biological studies of the title compounds in an acute in vivo experiment did not reveal their hypnotic properties and ability to enhance the effects...

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Veröffentlicht in:	Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2020-06, Vol.56 (6), p.769-775
Hauptverfasser:	Novakov, Ivan А., Brunilina, Leila L., Kirillov, Ivan А., Nawrozkij, Maxim B., Robinovich, Mariya D., Titova, Evgeniya S., Sheikin, Dmitry S., Ruchko, Evsey А., Pavlova, Alla V., Kotlyarova, Anastasiya А., Tolstikova, Tatyana G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Analogs Benzodiazepines Biological activity Chemistry Chemistry and Materials Science Chloral Comparative analysis Diazepam In vivo methods and tests Organic Chemistry Pharmacy Technical institutes Uracil
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Beschreibung
Zusammenfassung:	New structural analogs of 3-phenacyluridine were obtained as a result of N (3)-alkylation of 1-(2-acetoxyethyl)- and 1-(2-acetoxyethoxymethyl) uracil. Biological studies of the title compounds in an acute in vivo experiment did not reveal their hypnotic properties and ability to enhance the effects of diazepam and chloral hydrate.
ISSN:	0009-3122 1573-8353
DOI:	10.1007/s10593-020-02729-x