An antibody-supermolecule conjugate for tumor-specific targeting of tumoricidal methylated β-cyclodextrin-threaded polyrotaxanes

We previously found that acid-labile polyrotaxane containing methylated β-cyclodextrin (Me-PRX) induces endoplasmic reticulum (ER) stress-related autophagy and autophagic cell death. Me-PRX-induced autophagic cell death occurs even in apoptosis-resistant cells; tumor-targeted Me-PRX delivery could t...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-08, Vol.8 (31), p.6975-6987
Hauptverfasser:	Nishida, Kei, Tamura, Astushi, Kang, Tae Woong, Masuda, Hiroki, Yui, Nobuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Autophagy beta-Cyclodextrins - chemistry Cancer Cell death Cell Line, Tumor Chemotherapy Conjugates Cyclodextrins Cyclodextrins - chemistry Drug Carriers - chemistry Endoplasmic reticulum ErbB-2 protein Humans Immunoconjugates - chemistry Immunoconjugates - metabolism Immunoconjugates - therapeutic use Methylation Molecular Targeted Therapy Monoclonal antibodies Phagocytosis Poloxamer - chemistry Rotaxanes - chemistry Targeted cancer therapy Trastuzumab Trastuzumab - chemistry Tumor cells Tumors β-Cyclodextrin
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