Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats
The antioxidant and cardioprotective effects of oleuropein have been reported in several studies; however, its effect on ketamine cardiotoxicity has not been known yet. The aim of this study was to investigate the effects of oleuropein in ketamine-induced cardiotoxicity model in rats. A total of 28...
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| creator | Çömez, Mehmet Selim Cellat, Mustafa Özkan, Hüseyin Borazan, Yakup Aydın, Tuba Gökçek, İshak Türk, Erdinç Güvenç, Mehmet Çakır, Ahmet Özsoy, Şule Yurdagül |
| description | The antioxidant and cardioprotective effects of oleuropein have been reported in several studies; however, its effect on ketamine cardiotoxicity has not been known yet. The aim of this study was to investigate the effects of oleuropein in ketamine-induced cardiotoxicity model in rats. A total of 28 male Wistar Albino rats were included in the study and they were randomly divided into four groups, each having seven rats. Group 1 (control): rats were given 1 mL of DMSO by oral gavage method for 7 days. Group 2 (ketamine): on the seventh day of the study, 60 mg/kg ketamine was administered intraperitoneally. Then, 60 mg/kg ketamine was administered intraperitoneally every 10 min for 3 h. Group 3 (oleuropein): rats were given 200 mg/kg/day oleuropein by oral gavage method for 7 days. Group 4 (oleuropein + ketamine): rats were given 1 × 200 mg/kg oleuropein by oral gavage method for 7 days. Furthermore, 60 mg/kg ketamine was administered intraperitoneally on the seventh day of the experiment. Then, 60 mg/kg ketamine was administered intraperitoneally every 10 min for 3 h. Serum cardiac marker (TnI, CK-MB and CK) levels were measured. Histopathological analysis was performed on a portion of the cardiac tissue. Cardiac tissue oxidative stress and antioxidant markers (MDA, GSH, GSH.Px and CAT), TNF-α, IL-6, NF-κB, COX-2 and Nrf-2 gene expressions, and protein conversion levels of related genes were determined. Data obtained showed that ketamine administration increased MDA (
p
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| doi_str_mv | 10.1007/s00210-020-01870-w |
| format | Article |
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p
< 0.001), TNF-α (
p
< 0.01), IL-6 (
p
< 0.01), COX-2 (
p
< 0.001) and NF-κB (
p
< 0.001) levels, as well as serum TnI (
p
< 0.001), CK-MB (
p
< 0.001) and CK (
p
< 0.01) levels whereas decreased GSH (
p
< 0.05) and Nrf-2 (
p
< 0.05) levels, as well as GSH-Px (
p
< 0.001) and CAT (
p
< 0.05) enzyme activities. Oleuropein administration was observed to decrease MDA, TNF-α, IL-6, COX-2, NF-κB, TnI, CK-MB and CK levels close to the control group and to increase GSH levels and GSH-Px and CAT enzyme activities close to the control group. This study showed that oleuropein administration reversed the increased oxidative stress and inflammation as a result of the use of ketamine and had protective effects on the heart.]]></description><identifier>ISSN: 0028-1298</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/s00210-020-01870-w</identifier><identifier>PMID: 32383030</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animal models ; Antioxidants ; Biomedical and Life Sciences ; Biomedicine ; Cardiotoxicity ; Chloramphenicol O-acetyltransferase ; Cyclooxygenase-2 ; Enzymatic activity ; Enzymes ; GA-binding protein ; Heart ; Interleukin 6 ; Ketamine ; Neurosciences ; NF-κB protein ; Original Article ; Oxidative stress ; Pharmacology/Toxicology ; Rodents ; Tumor necrosis factor-α</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 2020-09, Vol.393 (9), p.1691-1699</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-93a0ee599fa25363bf240e872dfe9f1414b4e9e9e2d8a2c5224bb476579c8d4b3</citedby><cites>FETCH-LOGICAL-c375t-93a0ee599fa25363bf240e872dfe9f1414b4e9e9e2d8a2c5224bb476579c8d4b3</cites><orcidid>0000-0003-0821-5148</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00210-020-01870-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00210-020-01870-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32383030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çömez, Mehmet Selim</creatorcontrib><creatorcontrib>Cellat, Mustafa</creatorcontrib><creatorcontrib>Özkan, Hüseyin</creatorcontrib><creatorcontrib>Borazan, Yakup</creatorcontrib><creatorcontrib>Aydın, Tuba</creatorcontrib><creatorcontrib>Gökçek, İshak</creatorcontrib><creatorcontrib>Türk, Erdinç</creatorcontrib><creatorcontrib>Güvenç, Mehmet</creatorcontrib><creatorcontrib>Çakır, Ahmet</creatorcontrib><creatorcontrib>Özsoy, Şule Yurdagül</creatorcontrib><title>Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn-Schmiedeberg's Arch Pharmacol</addtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description><![CDATA[The antioxidant and cardioprotective effects of oleuropein have been reported in several studies; however, its effect on ketamine cardiotoxicity has not been known yet. The aim of this study was to investigate the effects of oleuropein in ketamine-induced cardiotoxicity model in rats. A total of 28 male Wistar Albino rats were included in the study and they were randomly divided into four groups, each having seven rats. Group 1 (control): rats were given 1 mL of DMSO by oral gavage method for 7 days. Group 2 (ketamine): on the seventh day of the study, 60 mg/kg ketamine was administered intraperitoneally. Then, 60 mg/kg ketamine was administered intraperitoneally every 10 min for 3 h. Group 3 (oleuropein): rats were given 200 mg/kg/day oleuropein by oral gavage method for 7 days. Group 4 (oleuropein + ketamine): rats were given 1 × 200 mg/kg oleuropein by oral gavage method for 7 days. Furthermore, 60 mg/kg ketamine was administered intraperitoneally on the seventh day of the experiment. Then, 60 mg/kg ketamine was administered intraperitoneally every 10 min for 3 h. Serum cardiac marker (TnI, CK-MB and CK) levels were measured. Histopathological analysis was performed on a portion of the cardiac tissue. Cardiac tissue oxidative stress and antioxidant markers (MDA, GSH, GSH.Px and CAT), TNF-α, IL-6, NF-κB, COX-2 and Nrf-2 gene expressions, and protein conversion levels of related genes were determined. Data obtained showed that ketamine administration increased MDA (
p
< 0.001), TNF-α (
p
< 0.01), IL-6 (
p
< 0.01), COX-2 (
p
< 0.001) and NF-κB (
p
< 0.001) levels, as well as serum TnI (
p
< 0.001), CK-MB (
p
< 0.001) and CK (
p
< 0.01) levels whereas decreased GSH (
p
< 0.05) and Nrf-2 (
p
< 0.05) levels, as well as GSH-Px (
p
< 0.001) and CAT (
p
< 0.05) enzyme activities. Oleuropein administration was observed to decrease MDA, TNF-α, IL-6, COX-2, NF-κB, TnI, CK-MB and CK levels close to the control group and to increase GSH levels and GSH-Px and CAT enzyme activities close to the control group. This study showed that oleuropein administration reversed the increased oxidative stress and inflammation as a result of the use of ketamine and had protective effects on the heart.]]></description><subject>Animal models</subject><subject>Antioxidants</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiotoxicity</subject><subject>Chloramphenicol O-acetyltransferase</subject><subject>Cyclooxygenase-2</subject><subject>Enzymatic activity</subject><subject>Enzymes</subject><subject>GA-binding protein</subject><subject>Heart</subject><subject>Interleukin 6</subject><subject>Ketamine</subject><subject>Neurosciences</subject><subject>NF-κB protein</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Pharmacology/Toxicology</subject><subject>Rodents</subject><subject>Tumor necrosis factor-α</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kMtOwzAQRS0EouXxAyxQJNaB8SOxvUQVT1WCBawtJxmjlDYudkLp32NogR2yLI80Z-7Ih5ATCucUQF5EAEYhB5YuVRLy1Q4ZU8FZTjVlu2Sc-iqnTKsROYhxBgAlLYp9MuKMKw4cxuT-Mfge6759xwydS1XmXebnOAS_xLbLfJe9Ym8XbYd52zVDjU1W29C0vvcfbd326yxRwfbxiOw5O494vH0PyfP11dPkNp8-3NxNLqd5zWXR55pbQCy0dpYVvOSVYwJQSdY41I4KKiqBOh3WKMvqgjFRVUKWhdS1akTFD8nZJncZ_NuAsTczP4QurTQsfb5UQsoiUWxD1cHHGNCZZWgXNqwNBfOlz2z0maTPfOszqzR0uo0eqgU2vyM_vhLAN0BMre4Fw9_uf2I_Acnve1I</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Çömez, Mehmet Selim</creator><creator>Cellat, Mustafa</creator><creator>Özkan, Hüseyin</creator><creator>Borazan, Yakup</creator><creator>Aydın, Tuba</creator><creator>Gökçek, İshak</creator><creator>Türk, Erdinç</creator><creator>Güvenç, Mehmet</creator><creator>Çakır, Ahmet</creator><creator>Özsoy, Şule Yurdagül</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-0821-5148</orcidid></search><sort><creationdate>20200901</creationdate><title>Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats</title><author>Çömez, Mehmet Selim ; 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however, its effect on ketamine cardiotoxicity has not been known yet. The aim of this study was to investigate the effects of oleuropein in ketamine-induced cardiotoxicity model in rats. A total of 28 male Wistar Albino rats were included in the study and they were randomly divided into four groups, each having seven rats. Group 1 (control): rats were given 1 mL of DMSO by oral gavage method for 7 days. Group 2 (ketamine): on the seventh day of the study, 60 mg/kg ketamine was administered intraperitoneally. Then, 60 mg/kg ketamine was administered intraperitoneally every 10 min for 3 h. Group 3 (oleuropein): rats were given 200 mg/kg/day oleuropein by oral gavage method for 7 days. Group 4 (oleuropein + ketamine): rats were given 1 × 200 mg/kg oleuropein by oral gavage method for 7 days. Furthermore, 60 mg/kg ketamine was administered intraperitoneally on the seventh day of the experiment. Then, 60 mg/kg ketamine was administered intraperitoneally every 10 min for 3 h. Serum cardiac marker (TnI, CK-MB and CK) levels were measured. Histopathological analysis was performed on a portion of the cardiac tissue. Cardiac tissue oxidative stress and antioxidant markers (MDA, GSH, GSH.Px and CAT), TNF-α, IL-6, NF-κB, COX-2 and Nrf-2 gene expressions, and protein conversion levels of related genes were determined. Data obtained showed that ketamine administration increased MDA (
p
< 0.001), TNF-α (
p
< 0.01), IL-6 (
p
< 0.01), COX-2 (
p
< 0.001) and NF-κB (
p
< 0.001) levels, as well as serum TnI (
p
< 0.001), CK-MB (
p
< 0.001) and CK (
p
< 0.01) levels whereas decreased GSH (
p
< 0.05) and Nrf-2 (
p
< 0.05) levels, as well as GSH-Px (
p
< 0.001) and CAT (
p
< 0.05) enzyme activities. Oleuropein administration was observed to decrease MDA, TNF-α, IL-6, COX-2, NF-κB, TnI, CK-MB and CK levels close to the control group and to increase GSH levels and GSH-Px and CAT enzyme activities close to the control group. This study showed that oleuropein administration reversed the increased oxidative stress and inflammation as a result of the use of ketamine and had protective effects on the heart.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32383030</pmid><doi>10.1007/s00210-020-01870-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0821-5148</orcidid></addata></record> |
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| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 2020-09, Vol.393 (9), p.1691-1699 |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Animal models Antioxidants Biomedical and Life Sciences Biomedicine Cardiotoxicity Chloramphenicol O-acetyltransferase Cyclooxygenase-2 Enzymatic activity Enzymes GA-binding protein Heart Interleukin 6 Ketamine Neurosciences NF-κB protein Original Article Oxidative stress Pharmacology/Toxicology Rodents Tumor necrosis factor-α |
| title | Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats |
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