Zinc Switch in Pig Heart Lipoamide Dehydrogenase: Steady-State and Transient Kinetic Studies of the Diaphorase Reaction

Elevation of intracellular Zn 2+ following ischemia contributes to cell death by affecting mitochondrial function. Zn 2+ is a differential regulator of the mitochondrial enzyme lipoamide dehydrogenase (LADH) at physiological concentrations ( K a = 0.1 µM free zinc), inhibiting lipoamide and accelera...

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Veröffentlicht in:	Biochemistry (Moscow) 2020-08, Vol.85 (8), p.908-919
Hauptverfasser:	Gazaryan, I. G., Shchedrina, V. A., Klyachko, N. L., Zakhariants, A. A., Kazakov, S. V., Brown, A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,6-Dichloroindophenol - metabolism 2,6-Dichlorophenol Analysis Animals Benzoquinone Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Catalytic Domain Cell death Dehydrogenase Dehydrogenases Dihydrolipoamide Dehydrogenase - metabolism Electrons Enzymes Escherichia coli - enzymology Ferricyanide Hydrogen peroxide Hydrogen Peroxide - metabolism Ischemia Kinetics Life Sciences Microbiology Mitochondria Myocardium - metabolism NADH NADH dehydrogenase NADH Dehydrogenase - metabolism Nicotinamide adenine dinucleotide Oxidases Oxidation-Reduction Physiological aspects Quinone Quinones Rate constants Steady state Substrates Superoxide Superoxides - metabolism Swine Switches Thiols Thioredoxin-Disulfide Reductase - metabolism Ubiquinone Zinc Zinc - metabolism Zinc compounds
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