Highly sensitive retrospective determination of organophosphorous nerve agent biomarkers in human urine implemented in vivo in rabbit

Highly toxic organophosphorous nerve agents (OPAs) have been used in several armed conflicts and terror attacks in the last few decades. A new method for retrospective determination of alkyl methylphosphonic acid (AMPA) metabolites in urine after exposure to VX, GB and GF nerve agents was developed....

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Veröffentlicht in:	Archives of toxicology 2020-09, Vol.94 (9), p.3033-3044
Hauptverfasser:	Blanca, Merav, Shifrovitch, Avital, Dachir, Shlomit, Lazar, Shlomi, Elgarisi, Maor, Marder, Dana, Shamai Yamin, Tamar, Baranes, Shlomi, Avraham, Meir, Dekel Jaoui, Hani, Dagan, Shai, Weissberg, Avi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Ammonium Ammonium hydroxide Biocompatibility Biomarkers Biomedical and Life Sciences Biomedicine Cartridges Cycle time Environmental Health Exposure Human wastes In vivo methods and tests Liquid chromatography Mass spectrometry Mass spectroscopy Metabolites Nerve agents Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Quantitation Sample preparation Sarin Solid phases Terrorism Toxicokinetics and Metabolism Trace levels Urine Zirconium dioxide
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