Longitudinal association of type 2 diabetes and insulin therapy with muscle parameters in the KORA-Age study
Aims The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults. Methods In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D: n...
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| Veröffentlicht in: | Acta diabetologica 2020-09, Vol.57 (9), p.1057-1063 |
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| creator | Ferrari, Uta Then, Cornelia Rottenkolber, Marietta Selte, Canan Seissler, Jochen Conzade, Romy Linkohr, Birgit Peters, Annette Drey, Michael Thorand, Barbara |
| description | Aims
The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults.
Methods
In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D:
n
= 118; insulin treatment:
n
= 20), skeletal muscle index (SMI [kg/m
2
]), hand grip strength (GS [kg]), and a timed up and go test (TUG [s]) were performed at baseline and after a follow-up time of 3 years. The association of T2D and insulin therapy with changes in muscle parameters was analyzed using linear regression models.
Results
After adjustment for sex, age, BMI, physical activity, smoking, and multimorbidity, T2D was associated with the change in SMI during follow-up (
β
− 0.1 (95% CI − 0.3 to − 0.02) kg/m
2
;
p
= 0.02), but not with a change in GS (
β
− 0.9 (95% CI − 1.9 to 0.04) kg) or TUG (
β
− 0.1 (95% CI − 0.7 to 0.5) s). Insulin therapy was positively associated with change in SMI (
β
0.6 (95% CI 0.3–0.9) kg/m
2
;
p
= 0.001), but not in GS (
β
− 1.6 (95% CI − 4.1 to 0.8) kg) or TUG (
β
1.6 (95% CI − 0.2–3.4) s) in comparison with treatment with oral anti-diabetic medication alone.
Conclusions
Participants with T2D showed an accelerated decline in muscle mass compared to non-diabetic participants. Insulin therapy was associated with preserved muscle mass, but not muscle function parameters, indicating a discrepancy between muscle mass and function in this high-risk population. |
| doi_str_mv | 10.1007/s00592-020-01523-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2431253284</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2431253284</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-7b105c90461182a5d39d02a793e8b60851a8e1eb9fd1be2aa343f8c6f98388d13</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoun78AQ8S8BydTNJtclzEL1xYED2HtE3XSLetSYvsvzdaP26ehmGeeYd5CDnlcMEB8ssIkGlkgMCAZyhYvkNmXApkqRG7ZAZaAssk6gNyGOMrAMdcqH1yIBDlHHOYkWbZtWs_jJVvbUNtjF3p7eC7lnY1Hba9o0grbws3uEhtW1HfxrHxLR1eXLD9lr774YVuxlg2jvY22E0iQ6QTQR9Wjwu2WDsa04ntMdmrbRPdyXc9Is83109Xd2y5ur2_WixZKbkeWF5wyEoNcs65QptVQleANtfCqWIOKuNWOe4KXVe8cGitkKJW5bzWSihVcXFEzqfcPnRvo4uDee3GkB6MBqXgmAlUMlE4UWXoYgyuNn3wGxu2hoP5FGwmwSYJNl-CTZ6Wzr6jx2Ljqt-VH6MJEBMQ06hdu_B3-5_YDx3ThdE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2431253284</pqid></control><display><type>article</type><title>Longitudinal association of type 2 diabetes and insulin therapy with muscle parameters in the KORA-Age study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Ferrari, Uta ; Then, Cornelia ; Rottenkolber, Marietta ; Selte, Canan ; Seissler, Jochen ; Conzade, Romy ; Linkohr, Birgit ; Peters, Annette ; Drey, Michael ; Thorand, Barbara</creator><creatorcontrib>Ferrari, Uta ; Then, Cornelia ; Rottenkolber, Marietta ; Selte, Canan ; Seissler, Jochen ; Conzade, Romy ; Linkohr, Birgit ; Peters, Annette ; Drey, Michael ; Thorand, Barbara</creatorcontrib><description>Aims
The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults.
Methods
In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D:
n
= 118; insulin treatment:
n
= 20), skeletal muscle index (SMI [kg/m
2
]), hand grip strength (GS [kg]), and a timed up and go test (TUG [s]) were performed at baseline and after a follow-up time of 3 years. The association of T2D and insulin therapy with changes in muscle parameters was analyzed using linear regression models.
Results
After adjustment for sex, age, BMI, physical activity, smoking, and multimorbidity, T2D was associated with the change in SMI during follow-up (
β
− 0.1 (95% CI − 0.3 to − 0.02) kg/m
2
;
p
= 0.02), but not with a change in GS (
β
− 0.9 (95% CI − 1.9 to 0.04) kg) or TUG (
β
− 0.1 (95% CI − 0.7 to 0.5) s). Insulin therapy was positively associated with change in SMI (
β
0.6 (95% CI 0.3–0.9) kg/m
2
;
p
= 0.001), but not in GS (
β
− 1.6 (95% CI − 4.1 to 0.8) kg) or TUG (
β
1.6 (95% CI − 0.2–3.4) s) in comparison with treatment with oral anti-diabetic medication alone.
Conclusions
Participants with T2D showed an accelerated decline in muscle mass compared to non-diabetic participants. Insulin therapy was associated with preserved muscle mass, but not muscle function parameters, indicating a discrepancy between muscle mass and function in this high-risk population.</description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-020-01523-7</identifier><identifier>PMID: 32246270</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Age ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Insulin ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Muscle strength ; Original Article ; Physical activity ; Population studies ; Regression analysis ; Sarcopenia ; Skeletal muscle</subject><ispartof>Acta diabetologica, 2020-09, Vol.57 (9), p.1057-1063</ispartof><rights>Springer-Verlag Italia S.r.l., part of Springer Nature 2020</rights><rights>Springer-Verlag Italia S.r.l., part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-7b105c90461182a5d39d02a793e8b60851a8e1eb9fd1be2aa343f8c6f98388d13</citedby><cites>FETCH-LOGICAL-c419t-7b105c90461182a5d39d02a793e8b60851a8e1eb9fd1be2aa343f8c6f98388d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00592-020-01523-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00592-020-01523-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32246270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferrari, Uta</creatorcontrib><creatorcontrib>Then, Cornelia</creatorcontrib><creatorcontrib>Rottenkolber, Marietta</creatorcontrib><creatorcontrib>Selte, Canan</creatorcontrib><creatorcontrib>Seissler, Jochen</creatorcontrib><creatorcontrib>Conzade, Romy</creatorcontrib><creatorcontrib>Linkohr, Birgit</creatorcontrib><creatorcontrib>Peters, Annette</creatorcontrib><creatorcontrib>Drey, Michael</creatorcontrib><creatorcontrib>Thorand, Barbara</creatorcontrib><title>Longitudinal association of type 2 diabetes and insulin therapy with muscle parameters in the KORA-Age study</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description>Aims
The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults.
Methods
In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D:
n
= 118; insulin treatment:
n
= 20), skeletal muscle index (SMI [kg/m
2
]), hand grip strength (GS [kg]), and a timed up and go test (TUG [s]) were performed at baseline and after a follow-up time of 3 years. The association of T2D and insulin therapy with changes in muscle parameters was analyzed using linear regression models.
Results
After adjustment for sex, age, BMI, physical activity, smoking, and multimorbidity, T2D was associated with the change in SMI during follow-up (
β
− 0.1 (95% CI − 0.3 to − 0.02) kg/m
2
;
p
= 0.02), but not with a change in GS (
β
− 0.9 (95% CI − 1.9 to 0.04) kg) or TUG (
β
− 0.1 (95% CI − 0.7 to 0.5) s). Insulin therapy was positively associated with change in SMI (
β
0.6 (95% CI 0.3–0.9) kg/m
2
;
p
= 0.001), but not in GS (
β
− 1.6 (95% CI − 4.1 to 0.8) kg) or TUG (
β
1.6 (95% CI − 0.2–3.4) s) in comparison with treatment with oral anti-diabetic medication alone.
Conclusions
Participants with T2D showed an accelerated decline in muscle mass compared to non-diabetic participants. Insulin therapy was associated with preserved muscle mass, but not muscle function parameters, indicating a discrepancy between muscle mass and function in this high-risk population.</description><subject>Age</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Insulin</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Muscle strength</subject><subject>Original Article</subject><subject>Physical activity</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Sarcopenia</subject><subject>Skeletal muscle</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMoun78AQ8S8BydTNJtclzEL1xYED2HtE3XSLetSYvsvzdaP26ehmGeeYd5CDnlcMEB8ssIkGlkgMCAZyhYvkNmXApkqRG7ZAZaAssk6gNyGOMrAMdcqH1yIBDlHHOYkWbZtWs_jJVvbUNtjF3p7eC7lnY1Hba9o0grbws3uEhtW1HfxrHxLR1eXLD9lr774YVuxlg2jvY22E0iQ6QTQR9Wjwu2WDsa04ntMdmrbRPdyXc9Is83109Xd2y5ur2_WixZKbkeWF5wyEoNcs65QptVQleANtfCqWIOKuNWOe4KXVe8cGitkKJW5bzWSihVcXFEzqfcPnRvo4uDee3GkB6MBqXgmAlUMlE4UWXoYgyuNn3wGxu2hoP5FGwmwSYJNl-CTZ6Wzr6jx2Ljqt-VH6MJEBMQ06hdu_B3-5_YDx3ThdE</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Ferrari, Uta</creator><creator>Then, Cornelia</creator><creator>Rottenkolber, Marietta</creator><creator>Selte, Canan</creator><creator>Seissler, Jochen</creator><creator>Conzade, Romy</creator><creator>Linkohr, Birgit</creator><creator>Peters, Annette</creator><creator>Drey, Michael</creator><creator>Thorand, Barbara</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>20200901</creationdate><title>Longitudinal association of type 2 diabetes and insulin therapy with muscle parameters in the KORA-Age study</title><author>Ferrari, Uta ; Then, Cornelia ; Rottenkolber, Marietta ; Selte, Canan ; Seissler, Jochen ; Conzade, Romy ; Linkohr, Birgit ; Peters, Annette ; Drey, Michael ; Thorand, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-7b105c90461182a5d39d02a793e8b60851a8e1eb9fd1be2aa343f8c6f98388d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Muscle strength</topic><topic>Original Article</topic><topic>Physical activity</topic><topic>Population studies</topic><topic>Regression analysis</topic><topic>Sarcopenia</topic><topic>Skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrari, Uta</creatorcontrib><creatorcontrib>Then, Cornelia</creatorcontrib><creatorcontrib>Rottenkolber, Marietta</creatorcontrib><creatorcontrib>Selte, Canan</creatorcontrib><creatorcontrib>Seissler, Jochen</creatorcontrib><creatorcontrib>Conzade, Romy</creatorcontrib><creatorcontrib>Linkohr, Birgit</creatorcontrib><creatorcontrib>Peters, Annette</creatorcontrib><creatorcontrib>Drey, Michael</creatorcontrib><creatorcontrib>Thorand, Barbara</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Acta diabetologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrari, Uta</au><au>Then, Cornelia</au><au>Rottenkolber, Marietta</au><au>Selte, Canan</au><au>Seissler, Jochen</au><au>Conzade, Romy</au><au>Linkohr, Birgit</au><au>Peters, Annette</au><au>Drey, Michael</au><au>Thorand, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal association of type 2 diabetes and insulin therapy with muscle parameters in the KORA-Age study</atitle><jtitle>Acta diabetologica</jtitle><stitle>Acta Diabetol</stitle><addtitle>Acta Diabetol</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>57</volume><issue>9</issue><spage>1057</spage><epage>1063</epage><pages>1057-1063</pages><issn>0940-5429</issn><eissn>1432-5233</eissn><abstract>Aims
The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults.
Methods
In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D:
n
= 118; insulin treatment:
n
= 20), skeletal muscle index (SMI [kg/m
2
]), hand grip strength (GS [kg]), and a timed up and go test (TUG [s]) were performed at baseline and after a follow-up time of 3 years. The association of T2D and insulin therapy with changes in muscle parameters was analyzed using linear regression models.
Results
After adjustment for sex, age, BMI, physical activity, smoking, and multimorbidity, T2D was associated with the change in SMI during follow-up (
β
− 0.1 (95% CI − 0.3 to − 0.02) kg/m
2
;
p
= 0.02), but not with a change in GS (
β
− 0.9 (95% CI − 1.9 to 0.04) kg) or TUG (
β
− 0.1 (95% CI − 0.7 to 0.5) s). Insulin therapy was positively associated with change in SMI (
β
0.6 (95% CI 0.3–0.9) kg/m
2
;
p
= 0.001), but not in GS (
β
− 1.6 (95% CI − 4.1 to 0.8) kg) or TUG (
β
1.6 (95% CI − 0.2–3.4) s) in comparison with treatment with oral anti-diabetic medication alone.
Conclusions
Participants with T2D showed an accelerated decline in muscle mass compared to non-diabetic participants. Insulin therapy was associated with preserved muscle mass, but not muscle function parameters, indicating a discrepancy between muscle mass and function in this high-risk population.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>32246270</pmid><doi>10.1007/s00592-020-01523-7</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta diabetologica, 2020-09, Vol.57 (9), p.1057-1063 |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Age Diabetes Diabetes mellitus (non-insulin dependent) Insulin Internal Medicine Medicine Medicine & Public Health Metabolic Diseases Muscle strength Original Article Physical activity Population studies Regression analysis Sarcopenia Skeletal muscle |
| title | Longitudinal association of type 2 diabetes and insulin therapy with muscle parameters in the KORA-Age study |
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