Copper‐Catalyzed One‐Pot Synthesis of 3‐(N‐Heteroarenyl)acrylonitriles through Radical Conjugated Addition of β‐Nitrostyrene to Methylazaarenes

A simple procedure for the copper‐catalyzed synthesis of 3‐(N‐heteroaryl)acrylonitriles was developed. Using a combination of Lewis and Brønsted acids, this one‐pot procedure undergoes via a radical conjugated addition and dehydration processes, without isolation of any intermediate, affording the a...

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Veröffentlicht in:	European journal of organic chemistry 2020-08, Vol.2020 (29), p.4563-4570
Hauptverfasser:	Moreira, Natália M., Martelli, Lorena S. R., Julio, Kiyara I. R., Zukerman‐Schpector, Julio, Opatz, Till, Corrêa, Arlene G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylonitriles Chemical synthesis Copper C‐H activation Dehydration Nitrogen heterocycles Organic compounds Radical reactions Stereoselectivity Synthetic methods
Online-Zugang:	Volltext
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