Cryo-EM structures of intact V-ATPase from bovine brain

The vacuolar-type H + -ATPases (V-ATPase) hydrolyze ATP to pump protons across the plasma or intracellular membrane, secreting acids to the lumen or acidifying intracellular compartments. It has been implicated in tumor metastasis, renal tubular acidosis, and osteoporosis. Here, we report two cryo-E...

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Veröffentlicht in:	Nature communications 2020-08, Vol.11 (1), p.3921-3921, Article 3921
Hauptverfasser:	Wang, Rong, Long, Tao, Hassan, Abdirahman, Wang, Jin, Sun, Yingyuan, Xie, Xiao-Song, Li, Xiaochun
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/45/535/1258/1259 631/57/2271 631/57/2283 Acidification Acidosis Adenosine triphosphatase Adenosine Triphosphate - metabolism Animals ATP Biomedical materials Brain Brain - enzymology Cattle Cryoelectron Microscopy H+-transporting ATPase Humanities and Social Sciences Hydrogen Hydrolysis Intracellular Lipids Mass spectrometry Membrane proteins Membranes Metastases Metastasis Models, Molecular multidisciplinary Multidisciplinary Sciences Osteoporosis Physiology Protein Interaction Domains and Motifs Protein Multimerization Protein Structure, Quaternary Protein Subunits Protons Receptors Renal tubular acidosis Renin Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Scientific imaging Vacuolar Proton-Translocating ATPases - chemistry Vacuolar Proton-Translocating ATPases - metabolism Vacuolar Proton-Translocating ATPases - ultrastructure
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