A short peptide that preferentially binds c-MYC G-quadruplex DNA

G-quadruplexes (G4s) are non-canonical DNA secondary structures. The identification of selective tools to probe individual G4s over the ∼700 000 found in the human genome is key to unravel the biological significance of specific G4s. We took inspiration from a crystal structure of the bovine DHX36 h...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2020-08, Vol.56 (63), p.894-8943
Hauptverfasser:	Minard, Aisling, Morgan, Danielle, Raguseo, Federica, Di Porzio, Anna, Liano, Denise, Jamieson, Andrew G, Di Antonio, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cattle Chemistry Chemistry, Multidisciplinary Crystal structure DEAD-box RNA Helicases - chemistry DEAD-box RNA Helicases - metabolism Deoxyribonucleic acid DNA Fluorescence Polarization G-Quadruplexes Humans Nucleic Acid Conformation Peptides Peptides - chemistry Peptides - metabolism Physical Sciences Promoter Regions, Genetic Protein Binding Proto-Oncogene Proteins c-myc - genetics Science & Technology
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