The relationship between PNP, GSTO-1, AS3MT and ADRB3 gene polymorphisms and urinary arsenic concentration among copper smelter and refinery employers
Introduction: The aim of this study was to assess the relationship between polymorphisms of genes encoding enzymes involved in arsenic metabolism and urinary arsenic concentration in people occupationally exposed to arsenic. Materials and Methods: The data from 113 employers directly exposed to lead...
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| Veröffentlicht in: | Human & experimental toxicology 2020-11, Vol.39 (11), p.1443-1453 |
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| creator | Szymańska-Chabowska, A Matys, T Łaczmański, Ł Czerwińska, K Janus, A Smyk, B Mazur, G Poręba, R Gać, P |
| description | Introduction:
The aim of this study was to assess the relationship between polymorphisms of genes encoding enzymes involved in arsenic metabolism and urinary arsenic concentration in people occupationally exposed to arsenic.
Materials and Methods:
The data from 113 employers directly exposed to lead, cadmium, and arsenic in copper smelter in Legnica and Glogow were collected. Urinary arsenic concentration was measured. In addition, blood level of cadmium, lead, and zinc protoporphyrins was assayed. Genetic analyses included polymorphism of PNP (rs 1130650), GSTO-1 (rs 4925), AS3MT (rs 11191439), and ADRB3 (rs4994) genes.
Results:
Individuals occupationally exposed to arsenic compounds, who have allele T in homozygous constellation in locus rs 1130650 of PNP gene, are predisposed to lower urinary arsenic concentration, while AA homozygosity in locus rs 4925 of GSTO-1 gene may result in statistically significant higher urinary arsenic concentration. Polymorphisms of AS3MT and ADRB3 genes showed no statistically significant correlation with urinary arsenic, however, there was a tendency to higher arsenic concentration in allele A carriers in locus rs4994 of ADRB3 gene and in allele T carriers in rs 11191439 of AS3MT gene.
Conclusion:
This study indicates that arsenic absorption and metabolism depend on polymorphisms of genes encoding PNP and GSTO-1. Individuals with disadvantageous constellation of polymorphisms are more susceptible to harmful effects of arsenic exposure. |
| doi_str_mv | 10.1177/0960327120925891 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_proquest_journals_2430621041</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0960327120925891</sage_id><sourcerecordid>2430621041</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-e504912297a911c1430b18ecdb5554c969de5a5792de3d65f1e709db617ab30a3</originalsourceid><addsrcrecordid>eNp1kUtP6zAQhS0EgvLYs0KW2BLw2HFcL0u5cJF4Cco6cpJpG5TYwU6F-kfu770u5SEhsRppzjnf2DOEHAI7BVDqjOmMCa6AM83lUMMGGUCqVMI0E5tksJKTlb5DdkN4YYxlWsI22RE8lZzz4YD8m8yRemxMXzsb5nVHC-zfEC19uHs4oVdPk_sETujoSdxOqLEVHV08ngs6Q4u0c82ydb6b16EN7-LC19b4JTU-oK1LWjpbou39O52a1tlZ7HUdehpabPpYVzGP09pizGHbNW6JPuyTralpAh581D3yfPlnMv6b3NxfXY9HN0kpMtknKFmqgXOtjAYoIRWsgCGWVSGlTEud6QqlkUrzCkWVySmgYroqMlCmEMyIPXK85nbevS4w9PmLW3gbR-Y8wjIOLIXoYmtX6V0I8bV55-s2fjQHlq8Okf88RIwcfYAXRYvVV-Bz89GQrA3BzPB76q_A_3OJj-s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2430621041</pqid></control><display><type>article</type><title>The relationship between PNP, GSTO-1, AS3MT and ADRB3 gene polymorphisms and urinary arsenic concentration among copper smelter and refinery employers</title><source>SAGE Open Access</source><creator>Szymańska-Chabowska, A ; Matys, T ; Łaczmański, Ł ; Czerwińska, K ; Janus, A ; Smyk, B ; Mazur, G ; Poręba, R ; Gać, P</creator><creatorcontrib>Szymańska-Chabowska, A ; Matys, T ; Łaczmański, Ł ; Czerwińska, K ; Janus, A ; Smyk, B ; Mazur, G ; Poręba, R ; Gać, P</creatorcontrib><description>Introduction:
The aim of this study was to assess the relationship between polymorphisms of genes encoding enzymes involved in arsenic metabolism and urinary arsenic concentration in people occupationally exposed to arsenic.
Materials and Methods:
The data from 113 employers directly exposed to lead, cadmium, and arsenic in copper smelter in Legnica and Glogow were collected. Urinary arsenic concentration was measured. In addition, blood level of cadmium, lead, and zinc protoporphyrins was assayed. Genetic analyses included polymorphism of PNP (rs 1130650), GSTO-1 (rs 4925), AS3MT (rs 11191439), and ADRB3 (rs4994) genes.
Results:
Individuals occupationally exposed to arsenic compounds, who have allele T in homozygous constellation in locus rs 1130650 of PNP gene, are predisposed to lower urinary arsenic concentration, while AA homozygosity in locus rs 4925 of GSTO-1 gene may result in statistically significant higher urinary arsenic concentration. Polymorphisms of AS3MT and ADRB3 genes showed no statistically significant correlation with urinary arsenic, however, there was a tendency to higher arsenic concentration in allele A carriers in locus rs4994 of ADRB3 gene and in allele T carriers in rs 11191439 of AS3MT gene.
Conclusion:
This study indicates that arsenic absorption and metabolism depend on polymorphisms of genes encoding PNP and GSTO-1. Individuals with disadvantageous constellation of polymorphisms are more susceptible to harmful effects of arsenic exposure.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/0960327120925891</identifier><identifier>PMID: 32452228</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Alleles ; Arsenic ; Arsenic - urine ; Arsenic compounds ; Biological Monitoring ; Cadmium ; Constellations ; Copper ; Copper - blood ; Exposure ; Female ; Gene polymorphism ; Genes ; Genetic analysis ; Glutathione Transferase - genetics ; Homozygosity ; Humans ; Lead - blood ; Loci ; Male ; Metabolism ; Metallurgy ; Methyltransferases - genetics ; Middle Aged ; Occupational Exposure ; Pnp gene ; Polymorphism ; Polymorphism, Single Nucleotide ; Purine-Nucleoside Phosphorylase - genetics ; Receptors, Adrenergic, beta-3 - genetics ; Refineries ; Smelters ; Statistical analysis ; Statistical significance ; Zinc - blood</subject><ispartof>Human & experimental toxicology, 2020-11, Vol.39 (11), p.1443-1453</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-e504912297a911c1430b18ecdb5554c969de5a5792de3d65f1e709db617ab30a3</citedby><cites>FETCH-LOGICAL-c365t-e504912297a911c1430b18ecdb5554c969de5a5792de3d65f1e709db617ab30a3</cites><orcidid>0000-0001-8366-0239</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0960327120925891$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0960327120925891$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21957,27844,27915,27916,44936,45324</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0960327120925891?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32452228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szymańska-Chabowska, A</creatorcontrib><creatorcontrib>Matys, T</creatorcontrib><creatorcontrib>Łaczmański, Ł</creatorcontrib><creatorcontrib>Czerwińska, K</creatorcontrib><creatorcontrib>Janus, A</creatorcontrib><creatorcontrib>Smyk, B</creatorcontrib><creatorcontrib>Mazur, G</creatorcontrib><creatorcontrib>Poręba, R</creatorcontrib><creatorcontrib>Gać, P</creatorcontrib><title>The relationship between PNP, GSTO-1, AS3MT and ADRB3 gene polymorphisms and urinary arsenic concentration among copper smelter and refinery employers</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>Introduction:
The aim of this study was to assess the relationship between polymorphisms of genes encoding enzymes involved in arsenic metabolism and urinary arsenic concentration in people occupationally exposed to arsenic.
Materials and Methods:
The data from 113 employers directly exposed to lead, cadmium, and arsenic in copper smelter in Legnica and Glogow were collected. Urinary arsenic concentration was measured. In addition, blood level of cadmium, lead, and zinc protoporphyrins was assayed. Genetic analyses included polymorphism of PNP (rs 1130650), GSTO-1 (rs 4925), AS3MT (rs 11191439), and ADRB3 (rs4994) genes.
Results:
Individuals occupationally exposed to arsenic compounds, who have allele T in homozygous constellation in locus rs 1130650 of PNP gene, are predisposed to lower urinary arsenic concentration, while AA homozygosity in locus rs 4925 of GSTO-1 gene may result in statistically significant higher urinary arsenic concentration. Polymorphisms of AS3MT and ADRB3 genes showed no statistically significant correlation with urinary arsenic, however, there was a tendency to higher arsenic concentration in allele A carriers in locus rs4994 of ADRB3 gene and in allele T carriers in rs 11191439 of AS3MT gene.
Conclusion:
This study indicates that arsenic absorption and metabolism depend on polymorphisms of genes encoding PNP and GSTO-1. Individuals with disadvantageous constellation of polymorphisms are more susceptible to harmful effects of arsenic exposure.</description><subject>Adult</subject><subject>Alleles</subject><subject>Arsenic</subject><subject>Arsenic - urine</subject><subject>Arsenic compounds</subject><subject>Biological Monitoring</subject><subject>Cadmium</subject><subject>Constellations</subject><subject>Copper</subject><subject>Copper - blood</subject><subject>Exposure</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic analysis</subject><subject>Glutathione Transferase - genetics</subject><subject>Homozygosity</subject><subject>Humans</subject><subject>Lead - blood</subject><subject>Loci</subject><subject>Male</subject><subject>Metabolism</subject><subject>Metallurgy</subject><subject>Methyltransferases - genetics</subject><subject>Middle Aged</subject><subject>Occupational Exposure</subject><subject>Pnp gene</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Purine-Nucleoside Phosphorylase - genetics</subject><subject>Receptors, Adrenergic, beta-3 - genetics</subject><subject>Refineries</subject><subject>Smelters</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Zinc - blood</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtP6zAQhS0EgvLYs0KW2BLw2HFcL0u5cJF4Cco6cpJpG5TYwU6F-kfu770u5SEhsRppzjnf2DOEHAI7BVDqjOmMCa6AM83lUMMGGUCqVMI0E5tksJKTlb5DdkN4YYxlWsI22RE8lZzz4YD8m8yRemxMXzsb5nVHC-zfEC19uHs4oVdPk_sETujoSdxOqLEVHV08ngs6Q4u0c82ydb6b16EN7-LC19b4JTU-oK1LWjpbou39O52a1tlZ7HUdehpabPpYVzGP09pizGHbNW6JPuyTralpAh581D3yfPlnMv6b3NxfXY9HN0kpMtknKFmqgXOtjAYoIRWsgCGWVSGlTEud6QqlkUrzCkWVySmgYroqMlCmEMyIPXK85nbevS4w9PmLW3gbR-Y8wjIOLIXoYmtX6V0I8bV55-s2fjQHlq8Okf88RIwcfYAXRYvVV-Bz89GQrA3BzPB76q_A_3OJj-s</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Szymańska-Chabowska, A</creator><creator>Matys, T</creator><creator>Łaczmański, Ł</creator><creator>Czerwińska, K</creator><creator>Janus, A</creator><creator>Smyk, B</creator><creator>Mazur, G</creator><creator>Poręba, R</creator><creator>Gać, P</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0001-8366-0239</orcidid></search><sort><creationdate>202011</creationdate><title>The relationship between PNP, GSTO-1, AS3MT and ADRB3 gene polymorphisms and urinary arsenic concentration among copper smelter and refinery employers</title><author>Szymańska-Chabowska, A ; Matys, T ; Łaczmański, Ł ; Czerwińska, K ; Janus, A ; Smyk, B ; Mazur, G ; Poręba, R ; Gać, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-e504912297a911c1430b18ecdb5554c969de5a5792de3d65f1e709db617ab30a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Arsenic</topic><topic>Arsenic - urine</topic><topic>Arsenic compounds</topic><topic>Biological Monitoring</topic><topic>Cadmium</topic><topic>Constellations</topic><topic>Copper</topic><topic>Copper - blood</topic><topic>Exposure</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic analysis</topic><topic>Glutathione Transferase - genetics</topic><topic>Homozygosity</topic><topic>Humans</topic><topic>Lead - blood</topic><topic>Loci</topic><topic>Male</topic><topic>Metabolism</topic><topic>Metallurgy</topic><topic>Methyltransferases - genetics</topic><topic>Middle Aged</topic><topic>Occupational Exposure</topic><topic>Pnp gene</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Purine-Nucleoside Phosphorylase - genetics</topic><topic>Receptors, Adrenergic, beta-3 - genetics</topic><topic>Refineries</topic><topic>Smelters</topic><topic>Statistical analysis</topic><topic>Statistical significance</topic><topic>Zinc - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szymańska-Chabowska, A</creatorcontrib><creatorcontrib>Matys, T</creatorcontrib><creatorcontrib>Łaczmański, Ł</creatorcontrib><creatorcontrib>Czerwińska, K</creatorcontrib><creatorcontrib>Janus, A</creatorcontrib><creatorcontrib>Smyk, B</creatorcontrib><creatorcontrib>Mazur, G</creatorcontrib><creatorcontrib>Poręba, R</creatorcontrib><creatorcontrib>Gać, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Environment Abstracts</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Szymańska-Chabowska, A</au><au>Matys, T</au><au>Łaczmański, Ł</au><au>Czerwińska, K</au><au>Janus, A</au><au>Smyk, B</au><au>Mazur, G</au><au>Poręba, R</au><au>Gać, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between PNP, GSTO-1, AS3MT and ADRB3 gene polymorphisms and urinary arsenic concentration among copper smelter and refinery employers</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2020-11</date><risdate>2020</risdate><volume>39</volume><issue>11</issue><spage>1443</spage><epage>1453</epage><pages>1443-1453</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>Introduction:
The aim of this study was to assess the relationship between polymorphisms of genes encoding enzymes involved in arsenic metabolism and urinary arsenic concentration in people occupationally exposed to arsenic.
Materials and Methods:
The data from 113 employers directly exposed to lead, cadmium, and arsenic in copper smelter in Legnica and Glogow were collected. Urinary arsenic concentration was measured. In addition, blood level of cadmium, lead, and zinc protoporphyrins was assayed. Genetic analyses included polymorphism of PNP (rs 1130650), GSTO-1 (rs 4925), AS3MT (rs 11191439), and ADRB3 (rs4994) genes.
Results:
Individuals occupationally exposed to arsenic compounds, who have allele T in homozygous constellation in locus rs 1130650 of PNP gene, are predisposed to lower urinary arsenic concentration, while AA homozygosity in locus rs 4925 of GSTO-1 gene may result in statistically significant higher urinary arsenic concentration. Polymorphisms of AS3MT and ADRB3 genes showed no statistically significant correlation with urinary arsenic, however, there was a tendency to higher arsenic concentration in allele A carriers in locus rs4994 of ADRB3 gene and in allele T carriers in rs 11191439 of AS3MT gene.
Conclusion:
This study indicates that arsenic absorption and metabolism depend on polymorphisms of genes encoding PNP and GSTO-1. Individuals with disadvantageous constellation of polymorphisms are more susceptible to harmful effects of arsenic exposure.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32452228</pmid><doi>10.1177/0960327120925891</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8366-0239</orcidid></addata></record> |
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| issn | 0960-3271 1477-0903 |
| language | eng |
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| source | SAGE Open Access |
| subjects | Adult Alleles Arsenic Arsenic - urine Arsenic compounds Biological Monitoring Cadmium Constellations Copper Copper - blood Exposure Female Gene polymorphism Genes Genetic analysis Glutathione Transferase - genetics Homozygosity Humans Lead - blood Loci Male Metabolism Metallurgy Methyltransferases - genetics Middle Aged Occupational Exposure Pnp gene Polymorphism Polymorphism, Single Nucleotide Purine-Nucleoside Phosphorylase - genetics Receptors, Adrenergic, beta-3 - genetics Refineries Smelters Statistical analysis Statistical significance Zinc - blood |
| title | The relationship between PNP, GSTO-1, AS3MT and ADRB3 gene polymorphisms and urinary arsenic concentration among copper smelter and refinery employers |
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