Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium

Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood and cognition. In vulnerable individuals, acute illness can also produce profound, maladaptive, cognitive dysfunction including delirium, but our u...

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Veröffentlicht in:	The Journal of neuroscience 2020-07, Vol.40 (29), p.5681-5696
Hauptverfasser:	Kealy, John, Murray, Carol, Griffin, Eadaoin W., Lopez-Rodriguez, Ana Belen, Healy, Daire, Tortorelli, Lucas Silva, Lowry, John P., Watne, Leiv Otto, Cunningham, Colm
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Brain Carbohydrate metabolism Carbohydrates Cerebrospinal fluid Cognition Cognition & reasoning Cognitive ability Cognitive Dysfunction - etiology Cognitive Dysfunction - metabolism Delirium Delirium - etiology Delirium - metabolism Deoxyglucose Disseminated infection Energy Metabolism Female Fractures Glucose Glucose - metabolism Glycolysis Hip Fractures - cerebrospinal fluid Hip Fractures - complications Humans Hypoglycemia IL-1β Illness Behavior - physiology Inflammation Inflammation - cerebrospinal fluid Inflammation - etiology Inflammation - metabolism Insulin Interleukin 1 Interleukin 1 receptor antagonist Interleukin-1beta - administration & dosage Lactic acid Life Sciences & Biomedicine Lipopolysaccharides Lipopolysaccharides - administration & dosage Locomotor activity Male Mental disorders Metabolism Metabolites Mice, Inbred C57BL Middle Aged Mood Neurodegeneration Neurosciences Neurosciences & Neurology Pyruvic acid Science & Technology Sickness behavior Trauma
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