α2A‐AR antagonism by BRL‐44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway

Acute respiratory distress syndrome (ARDS), characterized by acute hypoxic respiratory dysfunction or failure, is a manifestation of multiple organ failure in the lung, and the most common risk factor is sepsis. We previously showed that blocking α2‐adrenoceptor (α2‐AR) could attenuate lung injury i...

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Veröffentlicht in:	Journal of cellular physiology 2020-10, Vol.235 (10), p.6905-6914
Hauptverfasser:	Cong, Zhukai, Li, Dan, Tao, Yifan, Lv, Xiangpeng, Zhu, Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation acute respiratory distress syndrome Adrenergic receptors Alveoli BRL‐44408 maleate Cecum Cytokines Endotoxins Extracellular signal-regulated kinase Hypoxia Inflammatory diseases Inflammatory response Injuries JNK protein Kinases Lipopolysaccharides Lungs Macrophages MAPK and NF‐κB Phosphorylation Protein kinase A Proteins Respiratory distress syndrome Risk analysis Risk factors Sepsis Survival α2A‐AR
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