2-Ketoglutarate-Generated In Vitro Enzymatic Biosystem Facilitates Fe(II)/2-Ketoglutarate-Dependent Dioxygenase-Mediated C-H Bond Oxidation for (2s,3r,4s)-4-Hydroxyisoleucine Synthesis

Fe(II)/2-ketoglutarate-dependent dioxygenase (Fe(II)/2-KG DO)-mediated hydroxylation is a critical type of C-H bond functionalization for synthesizing hydroxy amino acids used as pharmaceutical raw materials and precursors. However, DO activity requires 2-ketoglutarate (2-KG), lack of which reduces...

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Veröffentlicht in:	International journal of molecular sciences 2020-07, Vol.21 (15), p.5347, Article 5347
Hauptverfasser:	Jing, Xiao-Ran, Liu, Huan, Nie, Yao, Xu, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	2-ketoglutarate generation Aliphatic compounds Amino Acid Oxidoreductases - chemistry Amino acids Biochemistry & Molecular Biology Cascade chemical reactions Catalase Catalase - chemistry Cell-Free System - chemistry Chemical reactions Chemistry Chemistry, Multidisciplinary Diabetes Dioxygenase Dioxygenases - chemistry Efficiency Enzyme kinetics Fe(II)/2-ketoglutarate-dependent dioxygenase Glutamic acid Hydrogen bonds Hydrogen peroxide Hydrogen Peroxide - chemistry Hydrophobicity hydroxy amino acids Hydroxylation Influence Insulin Iron Iron - chemistry Isoleucine - analogs & derivatives Isoleucine - chemical synthesis Isoleucine - chemistry Ketoglutaric acid Ketoglutaric Acids - chemistry L-Glutamate oxidase Life Sciences & Biomedicine Oxidation Pharmaceuticals Physical Sciences Raw materials regio- and stereo-selective synthesis Science & Technology sequential cascade reaction Sulfoxidation Sulfur
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