Characterization of Bovine Lactoferrin Nanoparticle Prepared by Desolvation Technique
Lactoferrin (Lf) nanoparticles have been developed as a carrier of drugs and gene. Two main methods, desolvation technique and emulsification method, for preparation of protein nanoparticles have been reported so far, but most of the previous reports of Lf nanoparticles preparation are limited to em...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2020/08/01, Vol.68(8), pp.766-772 |
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| creator | Taguchi, Kazuaki Chuang, Victor Tuan Giam Hashimoto, Mai Nakayama, Mayuki Sakuragi, Mina Enoki, Yuki Nishi, Koji Matsumoto, Kazuaki Seo, Hakaru Otagiri, Masaki Yamasaki, Keishi |
| description | Lactoferrin (Lf) nanoparticles have been developed as a carrier of drugs and gene. Two main methods, desolvation technique and emulsification method, for preparation of protein nanoparticles have been reported so far, but most of the previous reports of Lf nanoparticles preparation are limited to emulsification method. In this study, we investigated the optimal conditions by desolvation technique for the preparation of glutaraldehyde-crosslinked bovine Lf (bLf) nanoparticles within the size range of 100–200 nm, and evaluated their properties as a carrier for oral and intravenous drug delivery. The experimental results of dynamic light scattering and Transmission Electron Microscope suggested that glutaraldehyde-crosslinked bLf nanoparticles with 150 nm in size could be produced by addition of 2-propanol as the desolvating solvent into the bLf solution adjusted to pH 6, followed by crosslinking with glutaraldehyde. These cross-linked bLf nanoparticles were found to be compatible to blood components and resistant against rapid degradation by pepsin. Thus, cross-linked bLf nanoparticles prepared by desolvation technique can be applied as a drug carrier for intravenous administration and oral delivery. |
| doi_str_mv | 10.1248/cpb.c20-00222 |
| format | Article |
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Two main methods, desolvation technique and emulsification method, for preparation of protein nanoparticles have been reported so far, but most of the previous reports of Lf nanoparticles preparation are limited to emulsification method. In this study, we investigated the optimal conditions by desolvation technique for the preparation of glutaraldehyde-crosslinked bovine Lf (bLf) nanoparticles within the size range of 100–200 nm, and evaluated their properties as a carrier for oral and intravenous drug delivery. The experimental results of dynamic light scattering and Transmission Electron Microscope suggested that glutaraldehyde-crosslinked bLf nanoparticles with 150 nm in size could be produced by addition of 2-propanol as the desolvating solvent into the bLf solution adjusted to pH 6, followed by crosslinking with glutaraldehyde. These cross-linked bLf nanoparticles were found to be compatible to blood components and resistant against rapid degradation by pepsin. Thus, cross-linked bLf nanoparticles prepared by desolvation technique can be applied as a drug carrier for intravenous administration and oral delivery.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.c20-00222</identifier><identifier>PMID: 32741918</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>2-Propanol - chemistry ; Administration, Oral ; Animals ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Cattle ; Crosslinking ; desolvation technique ; Drug carriers ; Drug Carriers - chemistry ; Drug delivery ; Drug delivery systems ; Emulsification ; Glutaral - chemistry ; Glutaraldehyde ; Hemolysis - drug effects ; Hydrogen-Ion Concentration ; Intravenous administration ; Lactoferrin ; Lactoferrin - blood ; Lactoferrin - chemistry ; Light scattering ; nanoparticle ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - toxicity ; Particle Size ; Pepsin ; Photon correlation spectroscopy ; Propanol ; Rats</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2020/08/01, Vol.68(8), pp.766-772</ispartof><rights>2020 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-e9bec4ac544ed39caf7f37d47c0aeb4a824215794bcb9d3638a16d259d4ec113</citedby><cites>FETCH-LOGICAL-c702t-e9bec4ac544ed39caf7f37d47c0aeb4a824215794bcb9d3638a16d259d4ec113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32741918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taguchi, Kazuaki</creatorcontrib><creatorcontrib>Chuang, Victor Tuan Giam</creatorcontrib><creatorcontrib>Hashimoto, Mai</creatorcontrib><creatorcontrib>Nakayama, Mayuki</creatorcontrib><creatorcontrib>Sakuragi, Mina</creatorcontrib><creatorcontrib>Enoki, Yuki</creatorcontrib><creatorcontrib>Nishi, Koji</creatorcontrib><creatorcontrib>Matsumoto, Kazuaki</creatorcontrib><creatorcontrib>Seo, Hakaru</creatorcontrib><creatorcontrib>Otagiri, Masaki</creatorcontrib><creatorcontrib>Yamasaki, Keishi</creatorcontrib><creatorcontrib>Solo University</creatorcontrib><creatorcontrib>dSchool of Pharmacy and Biomedical Science</creatorcontrib><creatorcontrib>cSchool of Pharmacy</creatorcontrib><creatorcontrib>fDDS Research Institute</creatorcontrib><creatorcontrib>Curtin University</creatorcontrib><creatorcontrib>Sojo University</creatorcontrib><creatorcontrib>Monash University Malaysia</creatorcontrib><creatorcontrib>aFaculty of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>eDepartment of Nanoscience</creatorcontrib><creatorcontrib>bFaculty of Pharmacy</creatorcontrib><creatorcontrib>Keio University</creatorcontrib><title>Characterization of Bovine Lactoferrin Nanoparticle Prepared by Desolvation Technique</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Lactoferrin (Lf) nanoparticles have been developed as a carrier of drugs and gene. Two main methods, desolvation technique and emulsification method, for preparation of protein nanoparticles have been reported so far, but most of the previous reports of Lf nanoparticles preparation are limited to emulsification method. In this study, we investigated the optimal conditions by desolvation technique for the preparation of glutaraldehyde-crosslinked bovine Lf (bLf) nanoparticles within the size range of 100–200 nm, and evaluated their properties as a carrier for oral and intravenous drug delivery. The experimental results of dynamic light scattering and Transmission Electron Microscope suggested that glutaraldehyde-crosslinked bLf nanoparticles with 150 nm in size could be produced by addition of 2-propanol as the desolvating solvent into the bLf solution adjusted to pH 6, followed by crosslinking with glutaraldehyde. These cross-linked bLf nanoparticles were found to be compatible to blood components and resistant against rapid degradation by pepsin. Thus, cross-linked bLf nanoparticles prepared by desolvation technique can be applied as a drug carrier for intravenous administration and oral delivery.</description><subject>2-Propanol - chemistry</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Cattle</subject><subject>Crosslinking</subject><subject>desolvation technique</subject><subject>Drug carriers</subject><subject>Drug Carriers - chemistry</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Emulsification</subject><subject>Glutaral - chemistry</subject><subject>Glutaraldehyde</subject><subject>Hemolysis - drug effects</subject><subject>Hydrogen-Ion Concentration</subject><subject>Intravenous administration</subject><subject>Lactoferrin</subject><subject>Lactoferrin - blood</subject><subject>Lactoferrin - chemistry</subject><subject>Light scattering</subject><subject>nanoparticle</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - toxicity</subject><subject>Particle Size</subject><subject>Pepsin</subject><subject>Photon correlation spectroscopy</subject><subject>Propanol</subject><subject>Rats</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc2P0zAQxS0EYrsLR64oEucs44_EzhG6sItUAYdythxnQl2lcbHTlZa_nmlTupex5Xl-b_wzY-843HKhzEe_b2-9gBJACPGCLbhUuqyEkC_ZAgCaUshaXrHrnLckqUDL1-xKCq14w82C_VpuXHJ-whT-uinEsYh98Tk-hhGLFZ3HHlMKY_HdjXHv0hT8gMXPhLTHrmifijvMcXicr67Rb8bw54Bv2KveDRnfntcbtv76Zb18KFc_7r8tP61Kr0FMJTYteuV8pRR2svGu173UndIeHLbKGaEEr3SjWt82Hb3DOF53omo6hZ5zecM-zLb7FCk1T3YbD2mkREs3m6rShgOpylnlU8w5YW_3KexcerIc7JGhJYaWGNoTQ9K_P7se2h12F_V_aCS4nwXUDd4NcRwI13O2z9pvcBesgJNpbcBYoDDQdU1FC1npGvRxtOXstM2T-42XqDPo02C1seZYLgM-d-nrLI7yH5RVnCQ</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Taguchi, Kazuaki</creator><creator>Chuang, Victor Tuan Giam</creator><creator>Hashimoto, Mai</creator><creator>Nakayama, Mayuki</creator><creator>Sakuragi, Mina</creator><creator>Enoki, Yuki</creator><creator>Nishi, Koji</creator><creator>Matsumoto, Kazuaki</creator><creator>Seo, Hakaru</creator><creator>Otagiri, Masaki</creator><creator>Yamasaki, Keishi</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20200801</creationdate><title>Characterization of Bovine Lactoferrin Nanoparticle Prepared by Desolvation Technique</title><author>Taguchi, Kazuaki ; Chuang, Victor Tuan Giam ; Hashimoto, Mai ; Nakayama, Mayuki ; Sakuragi, Mina ; Enoki, Yuki ; Nishi, Koji ; Matsumoto, Kazuaki ; Seo, Hakaru ; Otagiri, Masaki ; Yamasaki, Keishi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-e9bec4ac544ed39caf7f37d47c0aeb4a824215794bcb9d3638a16d259d4ec113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>2-Propanol - chemistry</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Cattle</topic><topic>Crosslinking</topic><topic>desolvation technique</topic><topic>Drug carriers</topic><topic>Drug Carriers - chemistry</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Emulsification</topic><topic>Glutaral - chemistry</topic><topic>Glutaraldehyde</topic><topic>Hemolysis - drug effects</topic><topic>Hydrogen-Ion Concentration</topic><topic>Intravenous administration</topic><topic>Lactoferrin</topic><topic>Lactoferrin - blood</topic><topic>Lactoferrin - chemistry</topic><topic>Light scattering</topic><topic>nanoparticle</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - toxicity</topic><topic>Particle Size</topic><topic>Pepsin</topic><topic>Photon correlation spectroscopy</topic><topic>Propanol</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taguchi, Kazuaki</creatorcontrib><creatorcontrib>Chuang, Victor Tuan Giam</creatorcontrib><creatorcontrib>Hashimoto, Mai</creatorcontrib><creatorcontrib>Nakayama, Mayuki</creatorcontrib><creatorcontrib>Sakuragi, Mina</creatorcontrib><creatorcontrib>Enoki, Yuki</creatorcontrib><creatorcontrib>Nishi, Koji</creatorcontrib><creatorcontrib>Matsumoto, Kazuaki</creatorcontrib><creatorcontrib>Seo, Hakaru</creatorcontrib><creatorcontrib>Otagiri, Masaki</creatorcontrib><creatorcontrib>Yamasaki, Keishi</creatorcontrib><creatorcontrib>Solo University</creatorcontrib><creatorcontrib>dSchool of Pharmacy and Biomedical Science</creatorcontrib><creatorcontrib>cSchool of Pharmacy</creatorcontrib><creatorcontrib>fDDS Research Institute</creatorcontrib><creatorcontrib>Curtin University</creatorcontrib><creatorcontrib>Sojo University</creatorcontrib><creatorcontrib>Monash University Malaysia</creatorcontrib><creatorcontrib>aFaculty of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>eDepartment of Nanoscience</creatorcontrib><creatorcontrib>bFaculty of Pharmacy</creatorcontrib><creatorcontrib>Keio University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taguchi, Kazuaki</au><au>Chuang, Victor Tuan Giam</au><au>Hashimoto, Mai</au><au>Nakayama, Mayuki</au><au>Sakuragi, Mina</au><au>Enoki, Yuki</au><au>Nishi, Koji</au><au>Matsumoto, Kazuaki</au><au>Seo, Hakaru</au><au>Otagiri, Masaki</au><au>Yamasaki, Keishi</au><aucorp>Solo University</aucorp><aucorp>dSchool of Pharmacy and Biomedical Science</aucorp><aucorp>cSchool of Pharmacy</aucorp><aucorp>fDDS Research Institute</aucorp><aucorp>Curtin University</aucorp><aucorp>Sojo University</aucorp><aucorp>Monash University Malaysia</aucorp><aucorp>aFaculty of Pharmaceutical Sciences</aucorp><aucorp>eDepartment of Nanoscience</aucorp><aucorp>bFaculty of Pharmacy</aucorp><aucorp>Keio University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Bovine Lactoferrin Nanoparticle Prepared by Desolvation Technique</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>68</volume><issue>8</issue><spage>766</spage><epage>772</epage><pages>766-772</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Lactoferrin (Lf) nanoparticles have been developed as a carrier of drugs and gene. Two main methods, desolvation technique and emulsification method, for preparation of protein nanoparticles have been reported so far, but most of the previous reports of Lf nanoparticles preparation are limited to emulsification method. In this study, we investigated the optimal conditions by desolvation technique for the preparation of glutaraldehyde-crosslinked bovine Lf (bLf) nanoparticles within the size range of 100–200 nm, and evaluated their properties as a carrier for oral and intravenous drug delivery. The experimental results of dynamic light scattering and Transmission Electron Microscope suggested that glutaraldehyde-crosslinked bLf nanoparticles with 150 nm in size could be produced by addition of 2-propanol as the desolvating solvent into the bLf solution adjusted to pH 6, followed by crosslinking with glutaraldehyde. These cross-linked bLf nanoparticles were found to be compatible to blood components and resistant against rapid degradation by pepsin. Thus, cross-linked bLf nanoparticles prepared by desolvation technique can be applied as a drug carrier for intravenous administration and oral delivery.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>32741918</pmid><doi>10.1248/cpb.c20-00222</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 2-Propanol - chemistry Administration, Oral Animals Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Cattle Crosslinking desolvation technique Drug carriers Drug Carriers - chemistry Drug delivery Drug delivery systems Emulsification Glutaral - chemistry Glutaraldehyde Hemolysis - drug effects Hydrogen-Ion Concentration Intravenous administration Lactoferrin Lactoferrin - blood Lactoferrin - chemistry Light scattering nanoparticle Nanoparticles Nanoparticles - chemistry Nanoparticles - toxicity Particle Size Pepsin Photon correlation spectroscopy Propanol Rats |
| title | Characterization of Bovine Lactoferrin Nanoparticle Prepared by Desolvation Technique |
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