Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13C‐isotopomers derived from [U‐13C]fructose and [U‐13C]glucose

Purpose The pentose phosphate pathway (PPP) is an important component of hepatic intermediary metabolism. Jin et al developed an elegant 13C‐NMR method for measuring hepatic PPP flux by quantifying the distribution of glucose 13C‐isotopomers formed from [U‐13C]glycerol. We demonstrate that this appr...

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Veröffentlicht in:	Magnetic resonance in medicine 2020-11, Vol.84 (5), p.2765-2771
Hauptverfasser:	Belew, Getachew D., Di Nunzio, Giada, Tavares, Ludgero, Silva, Joao G., Torres, Alejandra N., Jones, John G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Conversion Drinking water Fluxes Fructose Glucokinase Glucose Glycerol Glycogen Glycogens indirect pathway Liver Magnetic resonance spectroscopy Metabolism NADPH NMR NMR spectroscopy Nuclear magnetic resonance Pentose Pentose phosphate pathway Precursors
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