Thymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testis

Background: Doxorubicin (DOX) is used for treatment of many cancer types. Thymoquinone (THQ) is a powerful antioxidant agent used for reducing side effects of several drugs. The aim of this study is to determine possible therapeutic effects of THQ on doxorubicin-induced testicular toxicity in rats....

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Veröffentlicht in:	Human & experimental toxicology 2020-10, Vol.39 (10), p.1364-1373
Hauptverfasser:	Öztürk, E, Kaymak, E, Akin, AT, Karabulut, D, Ünsal, H Murat, Yakan, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - toxicity Antioxidants Apoptosis Apoptosis - drug effects Benzoquinones - pharmacology Caspase-3 DNA nucleotidylexotransferase Doxorubicin Doxorubicin - toxicity Enzyme-linked immunosorbent assay Evaluation Hsp90 protein Male Olive oil Oxidants Oxidizing agents Protective Agents - pharmacology Rats Side effects Testes Testis - drug effects Testis - pathology Testosterone Testosterone - blood Tissues Toxicity
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