The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes

Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way to generate biocatalysts for synthetically interesting transformations in organic chemistry and biotechnology. In order for this protein engineering technique to be efficient, fast, and reliable, and also of r...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-08, Vol.59 (32), p.13204-13231
Hauptverfasser:	Qu, Ge, Li, Aitao, Acevedo‐Rocha, Carlos G., Sun, Zhoutong, Reetz, Manfred T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Bacteria - enzymology Biocatalysis Biocatalysts Biotechnology Chemical synthesis Combinatorial analysis Directed evolution Directed Molecular Evolution - methods Enzymes Enzymes - chemistry Enzymes - genetics Evolution Fungi - enzymology iterative saturation mutagenesis Learning algorithms Libraries Machine Learning Mutagenesis Mutagenesis, Site-Directed Optimization Organic Chemicals - chemical synthesis Organic chemistry Protein engineering Saturation Saturation mutagenesis Selectivity stereoselectivity synthetic genes
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