Advances in catalytic and protecting-group-free total synthesis of natural products: a recent update
Catalytic processes in protecting-group-free syntheses of natural products are fast emerging towards achieving the goal of efficiency and economy in total synthesis. Present day sustainable development in synthesis of natural products does not permit the luxury of using stoichiometric reagents and p...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-08, Vol.56 (61), p.8569-859 |
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| creator | Fernandes, Rodney A Kumar, Praveen Choudhary, Priyanka |
| description | Catalytic processes in protecting-group-free syntheses of natural products are fast emerging towards achieving the goal of efficiency and economy in total synthesis. Present day sustainable development in synthesis of natural products does not permit the luxury of using stoichiometric reagents and protecting groups. Catalysis and step-economy can contribute significantly toward economy and efficiency of synthesis. This feature article details the ingenious efforts by many researchers in the last couple of years toward concise total syntheses, based on catalytic steps and protecting-group-free-strategies. These would again serve as guidelines in future development of reagents and catalysts aimed at achieving higher efficiency and chemoselectivity to the point that catalysis and protecting-group-free synthesis will be an accepted common practice.
This feature article highlights the recently achieved efficient total syntheses of many natural products based on catalytic steps and protecting-group-free strategies, leading to overall economy and efficiency in synthesis. |
| doi_str_mv | 10.1039/d0cc02659j |
| format | Article |
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Present day sustainable development in synthesis of natural products does not permit the luxury of using stoichiometric reagents and protecting groups. Catalysis and step-economy can contribute significantly toward economy and efficiency of synthesis. This feature article details the ingenious efforts by many researchers in the last couple of years toward concise total syntheses, based on catalytic steps and protecting-group-free-strategies. These would again serve as guidelines in future development of reagents and catalysts aimed at achieving higher efficiency and chemoselectivity to the point that catalysis and protecting-group-free synthesis will be an accepted common practice.
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2020-08, Vol.56 (61), p.8569-859 |
| issn | 1359-7345 1364-548X |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Alkylation Berberine Alkaloids - chemical synthesis Berberine Alkaloids - chemistry Biological Products - chemical synthesis Biological Products - chemistry Caproates - chemical synthesis Caproates - chemistry Catalysis Chemical synthesis Diterpenes - chemical synthesis Diterpenes - chemistry Efficiency Imidazolidines - chemical synthesis Imidazolidines - chemistry Metals - chemistry Natural products Oxidation-Reduction Quinones - chemical synthesis Quinones - chemistry Reagents Stereoisomerism Sustainable development |
| title | Advances in catalytic and protecting-group-free total synthesis of natural products: a recent update |
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