Facile Synthesis of Ultrasmall, Highly Stable, and Biocompatible Gold Nanoparticles Stabilized with Lipoic Acid: Cytotoxicity and Structural Characterization
— Using the colloidal method, and lipoic acid as a stabilizer, ultrasmall gold nanoparticles with an average size of 2.5 nm were synthesized. They are highly stable, have COOH functional groups, at concentrations lower than 100 μg/mL are non-cytotoxic, and the synthesis route is simple and economica...
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| Veröffentlicht in: | Nanotechnologies in Russia 2019-11, Vol.14 (11-12), p.607-612 |
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| container_title | Nanotechnologies in Russia |
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| creator | Cornejo-Monroy, Delfino Sánchez-Santamaria, Betania Martínez-Gómez, Erwin Adán Olivas-Armendáriz, Imelda Villanueva-Montellano, Alfredo Arias-Cerón, José Saúl Castaño, Victor M. |
| description | —
Using the colloidal method, and lipoic acid as a stabilizer, ultrasmall gold nanoparticles with an average size of 2.5 nm were synthesized. They are highly stable, have COOH functional groups, at concentrations lower than 100 μg/mL are non-cytotoxic, and the synthesis route is simple and economical. UV–Vis, FT-IR, Raman, and TEM spectroscopy were used to analyze their stability, composition and morphology. Furthermore, the cytotoxicity of the gold nanoparticles was evaluated by MTT assay. |
| doi_str_mv | 10.1134/S199507801906003X |
| format | Article |
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Using the colloidal method, and lipoic acid as a stabilizer, ultrasmall gold nanoparticles with an average size of 2.5 nm were synthesized. They are highly stable, have COOH functional groups, at concentrations lower than 100 μg/mL are non-cytotoxic, and the synthesis route is simple and economical. UV–Vis, FT-IR, Raman, and TEM spectroscopy were used to analyze their stability, composition and morphology. Furthermore, the cytotoxicity of the gold nanoparticles was evaluated by MTT assay.</description><identifier>ISSN: 1995-0780</identifier><identifier>EISSN: 1995-0799</identifier><identifier>DOI: 10.1134/S199507801906003X</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Biocompatibility ; Chemistry and Materials Science ; Cytotoxicity ; Functional groups ; Gold ; Industrial and Production Engineering ; Infrared spectroscopy ; Lipoic acid ; Machines ; Manufacturing ; Materials Science ; Morphology ; Nanobiomedicine and Nanopharmaceuticals ; Nanoparticles ; Nanotechnology ; Processes ; Stability analysis ; Structural analysis ; Synthesis ; Toxicity</subject><ispartof>Nanotechnologies in Russia, 2019-11, Vol.14 (11-12), p.607-612</ispartof><rights>Pleiades Publishing, Ltd. 2019</rights><rights>Pleiades Publishing, Ltd. 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-149e03a3e8ffa34deb6748abe24a8a6a7b5d3061ae745e8038cdc2df1d15904b3</citedby><cites>FETCH-LOGICAL-c353t-149e03a3e8ffa34deb6748abe24a8a6a7b5d3061ae745e8038cdc2df1d15904b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S199507801906003X$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S199507801906003X$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Cornejo-Monroy, Delfino</creatorcontrib><creatorcontrib>Sánchez-Santamaria, Betania</creatorcontrib><creatorcontrib>Martínez-Gómez, Erwin Adán</creatorcontrib><creatorcontrib>Olivas-Armendáriz, Imelda</creatorcontrib><creatorcontrib>Villanueva-Montellano, Alfredo</creatorcontrib><creatorcontrib>Arias-Cerón, José Saúl</creatorcontrib><creatorcontrib>Castaño, Victor M.</creatorcontrib><title>Facile Synthesis of Ultrasmall, Highly Stable, and Biocompatible Gold Nanoparticles Stabilized with Lipoic Acid: Cytotoxicity and Structural Characterization</title><title>Nanotechnologies in Russia</title><addtitle>Nanotechnol Russia</addtitle><description>—
Using the colloidal method, and lipoic acid as a stabilizer, ultrasmall gold nanoparticles with an average size of 2.5 nm were synthesized. They are highly stable, have COOH functional groups, at concentrations lower than 100 μg/mL are non-cytotoxic, and the synthesis route is simple and economical. UV–Vis, FT-IR, Raman, and TEM spectroscopy were used to analyze their stability, composition and morphology. 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Using the colloidal method, and lipoic acid as a stabilizer, ultrasmall gold nanoparticles with an average size of 2.5 nm were synthesized. They are highly stable, have COOH functional groups, at concentrations lower than 100 μg/mL are non-cytotoxic, and the synthesis route is simple and economical. UV–Vis, FT-IR, Raman, and TEM spectroscopy were used to analyze their stability, composition and morphology. Furthermore, the cytotoxicity of the gold nanoparticles was evaluated by MTT assay.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S199507801906003X</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1995-0780 |
| ispartof | Nanotechnologies in Russia, 2019-11, Vol.14 (11-12), p.607-612 |
| issn | 1995-0780 1995-0799 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Biocompatibility Chemistry and Materials Science Cytotoxicity Functional groups Gold Industrial and Production Engineering Infrared spectroscopy Lipoic acid Machines Manufacturing Materials Science Morphology Nanobiomedicine and Nanopharmaceuticals Nanoparticles Nanotechnology Processes Stability analysis Structural analysis Synthesis Toxicity |
| title | Facile Synthesis of Ultrasmall, Highly Stable, and Biocompatible Gold Nanoparticles Stabilized with Lipoic Acid: Cytotoxicity and Structural Characterization |
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