Genetic Algorithm with Model-Updating-Based PLS Regression for the Spectrophotometric Determination of Clopidogrel, Atorvastatin, and Aspirin in the Presence of its Degradation Product

A novel spectrophotometric method is described, including multivariate regression/model updating, for the analysis of a quaternary mixture of clopidogrel, atorvastatin, aspirin, and its degradation product salicylic acid. The multivariate algorithms adopted are partial least squares with and without...

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