Quality of metabolic control, serum potassium, and aging are the major determinants of severity of musculoskeletal disorders in hospitalized diabetic patients
Background Diabetes is strongly associated with numerous musculoskeletal disorders (MSD) and may be considered as another group of diabetic complications. Objective We explored the association of diabetes type, duration, quality of metabolic control, applied therapy, and serum electrolytes, with pre...
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Veröffentlicht in: | International journal of diabetes in developing countries 2020-04, Vol.40 (2), p.296-302 |
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container_title | International journal of diabetes in developing countries |
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creator | Aleksandar, Jovanovic N. Smilic, Ljiljana Smilic, Tanja Markovic-Jovanovic, Snezana R. Mitic, Javorka Filimonovic, Jelena Ristic, Radica D. Adzic, Valdet Matejic, Nebojsa Jaksic, Bojan S. |
description | Background
Diabetes is strongly associated with numerous musculoskeletal disorders (MSD) and may be considered as another group of diabetic complications.
Objective
We explored the association of diabetes type, duration, quality of metabolic control, applied therapy, and serum electrolytes, with prevalence and extent of musculoskeletal disorders as well as radiographic and EMG changes.
Methods
The case-control clinical study involved 80 patients with type 1 and 2 diabetes hospitalized at General Hospital Berane and Clinical Center Podgorica, Montenegro, in 2013. More than half of the diabetics had MSD. Peripheral nerve disorders were diagnosed by EMG. The musculoskeletal disorders were evaluated using the translated Short Musculoskeletal Function Assessment (SMFA) questionnaire. The statistical methodology involved
T
-testing,
χ
2 test, Spearman’s multiple correlation, and ordinal logistic regression.
Results
The incidence and the severity of MSD were significantly related to patients age, duration of diabetes, quality of metabolic control, serum potassium, radiographic, and EMG findings. However, in the regression analysis, only aging, mean blood glucose levels, and serum potassium were associated with the significant risk for development of MSD.
Conclusion
Advanced age, metabolic control, and hypokalemia are the main determinants of both prevalence and extent of musculoskeletal disorders in diabetics. Along with the strict glycemic control, an additional effort should be taken to avoid potassium depletion associated with diabetic ketoacidosis and to maintain optimal potassium homeostasis in diabetic patients receiving insulin, diuretics, or suffer gastrointestinal motility disorders. |
doi_str_mv | 10.1007/s13410-019-00776-5 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2426559713</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2426559713</sourcerecordid><originalsourceid>FETCH-LOGICAL-c270t-f994ce1fe7d80c5dae596a7f8f3238dcf2a6ff0f8cf7bc3c0750ad8b2a2535e3</originalsourceid><addsrcrecordid>eNp9kU1qHDEQhUVwIGMnF8hKkK071s-o1VoGk9gBgwl4LzRSaaxJd6ujUgecw-SskTM23nlVVNV7XxU8Qj5y9pkzpi-Qyy1nHeOma63uO_WGbLgxQycHKU7IhhktO2kke0dOEQ-MKSV6uSF_f6xuTPWB5kgnqG6Xx-Spz3MteTynCGWd6JKrQ0zrdE7dHKjbp3lPXQFa74FO7pALDVChTGl2c8VHFsJvKM_cFf06ZvwJY7sw0pAwlwAFaZrpfcYltWn6A6Ft3A5qe2BxNUFDvSdvoxsRPjzVM3L37evd5XV3c3v1_fLLTeeFZrWLxmw98Ag6DMyr4ECZ3uk4RCnkEHwUro-RxcFHvfPSM62YC8NOOKGkAnlGPh2xS8m_VsBqD3ktc7toxVb0ShnNZVOJo8qXjFgg2qWkyZUHy5l9jMEeY7AtBvs_BquaSR5N2MTzHsoL-hXXP6HbkEo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2426559713</pqid></control><display><type>article</type><title>Quality of metabolic control, serum potassium, and aging are the major determinants of severity of musculoskeletal disorders in hospitalized diabetic patients</title><source>Springer Online Journals</source><creator>Aleksandar, Jovanovic N. ; Smilic, Ljiljana ; Smilic, Tanja ; Markovic-Jovanovic, Snezana R. ; Mitic, Javorka ; Filimonovic, Jelena ; Ristic, Radica D. ; Adzic, Valdet ; Matejic, Nebojsa ; Jaksic, Bojan S.</creator><creatorcontrib>Aleksandar, Jovanovic N. ; Smilic, Ljiljana ; Smilic, Tanja ; Markovic-Jovanovic, Snezana R. ; Mitic, Javorka ; Filimonovic, Jelena ; Ristic, Radica D. ; Adzic, Valdet ; Matejic, Nebojsa ; Jaksic, Bojan S.</creatorcontrib><description>Background
Diabetes is strongly associated with numerous musculoskeletal disorders (MSD) and may be considered as another group of diabetic complications.
Objective
We explored the association of diabetes type, duration, quality of metabolic control, applied therapy, and serum electrolytes, with prevalence and extent of musculoskeletal disorders as well as radiographic and EMG changes.
Methods
The case-control clinical study involved 80 patients with type 1 and 2 diabetes hospitalized at General Hospital Berane and Clinical Center Podgorica, Montenegro, in 2013. More than half of the diabetics had MSD. Peripheral nerve disorders were diagnosed by EMG. The musculoskeletal disorders were evaluated using the translated Short Musculoskeletal Function Assessment (SMFA) questionnaire. The statistical methodology involved
T
-testing,
χ
2 test, Spearman’s multiple correlation, and ordinal logistic regression.
Results
The incidence and the severity of MSD were significantly related to patients age, duration of diabetes, quality of metabolic control, serum potassium, radiographic, and EMG findings. However, in the regression analysis, only aging, mean blood glucose levels, and serum potassium were associated with the significant risk for development of MSD.
Conclusion
Advanced age, metabolic control, and hypokalemia are the main determinants of both prevalence and extent of musculoskeletal disorders in diabetics. Along with the strict glycemic control, an additional effort should be taken to avoid potassium depletion associated with diabetic ketoacidosis and to maintain optimal potassium homeostasis in diabetic patients receiving insulin, diuretics, or suffer gastrointestinal motility disorders.</description><identifier>ISSN: 0973-3930</identifier><identifier>EISSN: 1998-3832</identifier><identifier>DOI: 10.1007/s13410-019-00776-5</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Aging ; Blood glucose ; Diabetes ; Diabetes mellitus (insulin dependent) ; Diabetic ketoacidosis ; Diuretics ; Electromyography ; Family Medicine ; Gastric motility ; General Practice ; Health Administration ; Homeostasis ; Hypokalemia ; Insulin ; Ketoacidosis ; Medicine ; Medicine & Public Health ; Metabolism ; Musculoskeletal diseases ; Original Article ; Patients ; Peripheral nerves ; Potassium</subject><ispartof>International journal of diabetes in developing countries, 2020-04, Vol.40 (2), p.296-302</ispartof><rights>Research Society for Study of Diabetes in India 2019</rights><rights>Research Society for Study of Diabetes in India 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-f994ce1fe7d80c5dae596a7f8f3238dcf2a6ff0f8cf7bc3c0750ad8b2a2535e3</cites><orcidid>0000-0002-5461-4978</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13410-019-00776-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13410-019-00776-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Aleksandar, Jovanovic N.</creatorcontrib><creatorcontrib>Smilic, Ljiljana</creatorcontrib><creatorcontrib>Smilic, Tanja</creatorcontrib><creatorcontrib>Markovic-Jovanovic, Snezana R.</creatorcontrib><creatorcontrib>Mitic, Javorka</creatorcontrib><creatorcontrib>Filimonovic, Jelena</creatorcontrib><creatorcontrib>Ristic, Radica D.</creatorcontrib><creatorcontrib>Adzic, Valdet</creatorcontrib><creatorcontrib>Matejic, Nebojsa</creatorcontrib><creatorcontrib>Jaksic, Bojan S.</creatorcontrib><title>Quality of metabolic control, serum potassium, and aging are the major determinants of severity of musculoskeletal disorders in hospitalized diabetic patients</title><title>International journal of diabetes in developing countries</title><addtitle>Int J Diabetes Dev Ctries</addtitle><description>Background
Diabetes is strongly associated with numerous musculoskeletal disorders (MSD) and may be considered as another group of diabetic complications.
Objective
We explored the association of diabetes type, duration, quality of metabolic control, applied therapy, and serum electrolytes, with prevalence and extent of musculoskeletal disorders as well as radiographic and EMG changes.
Methods
The case-control clinical study involved 80 patients with type 1 and 2 diabetes hospitalized at General Hospital Berane and Clinical Center Podgorica, Montenegro, in 2013. More than half of the diabetics had MSD. Peripheral nerve disorders were diagnosed by EMG. The musculoskeletal disorders were evaluated using the translated Short Musculoskeletal Function Assessment (SMFA) questionnaire. The statistical methodology involved
T
-testing,
χ
2 test, Spearman’s multiple correlation, and ordinal logistic regression.
Results
The incidence and the severity of MSD were significantly related to patients age, duration of diabetes, quality of metabolic control, serum potassium, radiographic, and EMG findings. However, in the regression analysis, only aging, mean blood glucose levels, and serum potassium were associated with the significant risk for development of MSD.
Conclusion
Advanced age, metabolic control, and hypokalemia are the main determinants of both prevalence and extent of musculoskeletal disorders in diabetics. Along with the strict glycemic control, an additional effort should be taken to avoid potassium depletion associated with diabetic ketoacidosis and to maintain optimal potassium homeostasis in diabetic patients receiving insulin, diuretics, or suffer gastrointestinal motility disorders.</description><subject>Aging</subject><subject>Blood glucose</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetic ketoacidosis</subject><subject>Diuretics</subject><subject>Electromyography</subject><subject>Family Medicine</subject><subject>Gastric motility</subject><subject>General Practice</subject><subject>Health Administration</subject><subject>Homeostasis</subject><subject>Hypokalemia</subject><subject>Insulin</subject><subject>Ketoacidosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Musculoskeletal diseases</subject><subject>Original Article</subject><subject>Patients</subject><subject>Peripheral nerves</subject><subject>Potassium</subject><issn>0973-3930</issn><issn>1998-3832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU1qHDEQhUVwIGMnF8hKkK071s-o1VoGk9gBgwl4LzRSaaxJd6ujUgecw-SskTM23nlVVNV7XxU8Qj5y9pkzpi-Qyy1nHeOma63uO_WGbLgxQycHKU7IhhktO2kke0dOEQ-MKSV6uSF_f6xuTPWB5kgnqG6Xx-Spz3MteTynCGWd6JKrQ0zrdE7dHKjbp3lPXQFa74FO7pALDVChTGl2c8VHFsJvKM_cFf06ZvwJY7sw0pAwlwAFaZrpfcYltWn6A6Ft3A5qe2BxNUFDvSdvoxsRPjzVM3L37evd5XV3c3v1_fLLTeeFZrWLxmw98Ag6DMyr4ECZ3uk4RCnkEHwUro-RxcFHvfPSM62YC8NOOKGkAnlGPh2xS8m_VsBqD3ktc7toxVb0ShnNZVOJo8qXjFgg2qWkyZUHy5l9jMEeY7AtBvs_BquaSR5N2MTzHsoL-hXXP6HbkEo</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Aleksandar, Jovanovic N.</creator><creator>Smilic, Ljiljana</creator><creator>Smilic, Tanja</creator><creator>Markovic-Jovanovic, Snezana R.</creator><creator>Mitic, Javorka</creator><creator>Filimonovic, Jelena</creator><creator>Ristic, Radica D.</creator><creator>Adzic, Valdet</creator><creator>Matejic, Nebojsa</creator><creator>Jaksic, Bojan S.</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0002-5461-4978</orcidid></search><sort><creationdate>20200401</creationdate><title>Quality of metabolic control, serum potassium, and aging are the major determinants of severity of musculoskeletal disorders in hospitalized diabetic patients</title><author>Aleksandar, Jovanovic N. ; Smilic, Ljiljana ; Smilic, Tanja ; Markovic-Jovanovic, Snezana R. ; Mitic, Javorka ; Filimonovic, Jelena ; Ristic, Radica D. ; Adzic, Valdet ; Matejic, Nebojsa ; Jaksic, Bojan S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-f994ce1fe7d80c5dae596a7f8f3238dcf2a6ff0f8cf7bc3c0750ad8b2a2535e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aging</topic><topic>Blood glucose</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetic ketoacidosis</topic><topic>Diuretics</topic><topic>Electromyography</topic><topic>Family Medicine</topic><topic>Gastric motility</topic><topic>General Practice</topic><topic>Health Administration</topic><topic>Homeostasis</topic><topic>Hypokalemia</topic><topic>Insulin</topic><topic>Ketoacidosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Musculoskeletal diseases</topic><topic>Original Article</topic><topic>Patients</topic><topic>Peripheral nerves</topic><topic>Potassium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aleksandar, Jovanovic N.</creatorcontrib><creatorcontrib>Smilic, Ljiljana</creatorcontrib><creatorcontrib>Smilic, Tanja</creatorcontrib><creatorcontrib>Markovic-Jovanovic, Snezana R.</creatorcontrib><creatorcontrib>Mitic, Javorka</creatorcontrib><creatorcontrib>Filimonovic, Jelena</creatorcontrib><creatorcontrib>Ristic, Radica D.</creatorcontrib><creatorcontrib>Adzic, Valdet</creatorcontrib><creatorcontrib>Matejic, Nebojsa</creatorcontrib><creatorcontrib>Jaksic, Bojan S.</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>International journal of diabetes in developing countries</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aleksandar, Jovanovic N.</au><au>Smilic, Ljiljana</au><au>Smilic, Tanja</au><au>Markovic-Jovanovic, Snezana R.</au><au>Mitic, Javorka</au><au>Filimonovic, Jelena</au><au>Ristic, Radica D.</au><au>Adzic, Valdet</au><au>Matejic, Nebojsa</au><au>Jaksic, Bojan S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of metabolic control, serum potassium, and aging are the major determinants of severity of musculoskeletal disorders in hospitalized diabetic patients</atitle><jtitle>International journal of diabetes in developing countries</jtitle><stitle>Int J Diabetes Dev Ctries</stitle><date>2020-04-01</date><risdate>2020</risdate><volume>40</volume><issue>2</issue><spage>296</spage><epage>302</epage><pages>296-302</pages><issn>0973-3930</issn><eissn>1998-3832</eissn><abstract>Background
Diabetes is strongly associated with numerous musculoskeletal disorders (MSD) and may be considered as another group of diabetic complications.
Objective
We explored the association of diabetes type, duration, quality of metabolic control, applied therapy, and serum electrolytes, with prevalence and extent of musculoskeletal disorders as well as radiographic and EMG changes.
Methods
The case-control clinical study involved 80 patients with type 1 and 2 diabetes hospitalized at General Hospital Berane and Clinical Center Podgorica, Montenegro, in 2013. More than half of the diabetics had MSD. Peripheral nerve disorders were diagnosed by EMG. The musculoskeletal disorders were evaluated using the translated Short Musculoskeletal Function Assessment (SMFA) questionnaire. The statistical methodology involved
T
-testing,
χ
2 test, Spearman’s multiple correlation, and ordinal logistic regression.
Results
The incidence and the severity of MSD were significantly related to patients age, duration of diabetes, quality of metabolic control, serum potassium, radiographic, and EMG findings. However, in the regression analysis, only aging, mean blood glucose levels, and serum potassium were associated with the significant risk for development of MSD.
Conclusion
Advanced age, metabolic control, and hypokalemia are the main determinants of both prevalence and extent of musculoskeletal disorders in diabetics. Along with the strict glycemic control, an additional effort should be taken to avoid potassium depletion associated with diabetic ketoacidosis and to maintain optimal potassium homeostasis in diabetic patients receiving insulin, diuretics, or suffer gastrointestinal motility disorders.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s13410-019-00776-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5461-4978</orcidid></addata></record> |
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ispartof | International journal of diabetes in developing countries, 2020-04, Vol.40 (2), p.296-302 |
issn | 0973-3930 1998-3832 |
language | eng |
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source | Springer Online Journals |
subjects | Aging Blood glucose Diabetes Diabetes mellitus (insulin dependent) Diabetic ketoacidosis Diuretics Electromyography Family Medicine Gastric motility General Practice Health Administration Homeostasis Hypokalemia Insulin Ketoacidosis Medicine Medicine & Public Health Metabolism Musculoskeletal diseases Original Article Patients Peripheral nerves Potassium |
title | Quality of metabolic control, serum potassium, and aging are the major determinants of severity of musculoskeletal disorders in hospitalized diabetic patients |
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