Synthesis and antimycobacterial evaluation of pyridinyl- and pyrazinylhydrazone derivatives

Bioisosteric replacements are often tried goaling to affect the lipophilicity, polarity, and aqueous solubility of the substances, as a way to obtain therapeutically improved medicines. Also, hydrazonyl compounds are described with a wide range of pharmacological activities, having also recognized a...

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Veröffentlicht in:	Medicinal chemistry research 2020-09, Vol.29 (9), p.1662-1668
Hauptverfasser:	Pinheiro, Alessandra C., Nogueira, Thaís C. M., Pereira, Gabriela E., Lourenço, Cristina, de Souza, Marcus V. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Aromatic compounds Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Derivatives Ethambutol Inorganic Chemistry Lipophilicity Medicinal Chemistry Original Research Pharmacology/Toxicology Polarity Tuberculosis
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