Efficacy and safety of abrocitinib in adults and adolescents with moderate-to-severe atopic dermatitis (JADE MONO-1): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial

Abrocitinib, an oral selective Janus kinase 1 inhibitor, was effective and well tolerated in adults with moderate-to-severe atopic dermatitis in a phase 2b trial. We aimed to assess the efficacy and safety of abrocitinib monotherapy in adolescents and adults with moderate-to-severe atopic dermatitis...

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Veröffentlicht in:	The Lancet (British edition) 2020-07, Vol.396 (10246), p.255-266
Hauptverfasser:	Simpson, Eric L, Sinclair, Rodney, Forman, Seth, Wollenberg, Andreas, Aschoff, Roland, Cork, Michael, Bieber, Thomas, Thyssen, Jacob P, Yosipovitch, Gil, Flohr, Carsten, Magnolo, Nina, Maari, Catherine, Feeney, Claire, Biswas, Pinaki, Tatulych, Svitlana, Valdez, Hernan, Rojo, Ricardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adolescents Adult Adults Aged Atopic dermatitis Australia - epidemiology Canada - epidemiology Case-Control Studies Child Clinical trials Cytokines Dermatitis Dermatitis, Atopic - drug therapy Dermatitis, Atopic - pathology Double-Blind Method Double-blind studies Drug dosages Eczema Eczema - drug therapy Eczema - pathology Enzyme inhibitors Ethnic Groups Europe - epidemiology FDA approval Female Histamine Humans Interactive systems Janus kinase Janus Kinase 1 - antagonists & inhibitors Kinases Male Middle Aged Pathophysiology Patient safety Placebos - administration & dosage Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Pruritus Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrimidines - therapeutic use Randomization Safety Severity of Illness Index Skin Skin diseases Sulfonamides - administration & dosage Sulfonamides - adverse effects Sulfonamides - therapeutic use Teenagers Treatment Outcome United States - epidemiology
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