Free-radical scavenging activity of radioprotectors: comparison between clinically used radioprotectors and natural antioxidants
Clinically used radioprotectors, amifostine and cysteamine, have been shown to possess free-radical scavenging activities. Natural antioxidants also possess free-radical scavenging activities, some of which have been shown to have radioprotective capability. We carried out a quantitative determinati...
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| Veröffentlicht in: | Journal of radioanalytical and nuclear chemistry 2020-08, Vol.325 (2), p.695-700 |
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| container_title | Journal of radioanalytical and nuclear chemistry |
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| creator | Sueishi, Yoshimi Fujii, Takumi Nii, Risako |
| description | Clinically used radioprotectors, amifostine and cysteamine, have been shown to possess free-radical scavenging activities. Natural antioxidants also possess free-radical scavenging activities, some of which have been shown to have radioprotective capability. We carried out a quantitative determination of the scavenging abilities in amifostine and cysteamine and compared the potencies with natural antioxidants by using multiple free-radical scavenging method. Overall, amifostine and cysteamine showed scavenging activity as potent as natural antioxidants. We found a correlation between scavenging activity and radioprotective efficiency that was previously determined in rat thymocytes. These correlations are indicative that natural antioxidants can be effective radioprotectors. |
| doi_str_mv | 10.1007/s10967-020-07258-7 |
| format | Article |
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Natural antioxidants also possess free-radical scavenging activities, some of which have been shown to have radioprotective capability. We carried out a quantitative determination of the scavenging abilities in amifostine and cysteamine and compared the potencies with natural antioxidants by using multiple free-radical scavenging method. Overall, amifostine and cysteamine showed scavenging activity as potent as natural antioxidants. We found a correlation between scavenging activity and radioprotective efficiency that was previously determined in rat thymocytes. These correlations are indicative that natural antioxidants can be effective radioprotectors.</description><identifier>ISSN: 0236-5731</identifier><identifier>EISSN: 1588-2780</identifier><identifier>DOI: 10.1007/s10967-020-07258-7</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antioxidants ; Chemistry ; Chemistry and Materials Science ; Cysteamine ; Diagnostic Radiology ; Free radicals ; Free radicals (Chemistry) ; Hadrons ; Heavy Ions ; Inorganic Chemistry ; Nuclear Chemistry ; Nuclear Physics ; Physical Chemistry ; Radiation ; Radiolysis ; Scavenging ; Vitamin E</subject><ispartof>Journal of radioanalytical and nuclear chemistry, 2020-08, Vol.325 (2), p.695-700</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Akadémiai Kiadó, Budapest, Hungary 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-f65233a7f0fc6a4f13092453bdc805bb4964b8e9d802f8031daff8f4e5d0deed3</citedby><cites>FETCH-LOGICAL-c386t-f65233a7f0fc6a4f13092453bdc805bb4964b8e9d802f8031daff8f4e5d0deed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10967-020-07258-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10967-020-07258-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Sueishi, Yoshimi</creatorcontrib><creatorcontrib>Fujii, Takumi</creatorcontrib><creatorcontrib>Nii, Risako</creatorcontrib><title>Free-radical scavenging activity of radioprotectors: comparison between clinically used radioprotectors and natural antioxidants</title><title>Journal of radioanalytical and nuclear chemistry</title><addtitle>J Radioanal Nucl Chem</addtitle><description>Clinically used radioprotectors, amifostine and cysteamine, have been shown to possess free-radical scavenging activities. Natural antioxidants also possess free-radical scavenging activities, some of which have been shown to have radioprotective capability. We carried out a quantitative determination of the scavenging abilities in amifostine and cysteamine and compared the potencies with natural antioxidants by using multiple free-radical scavenging method. Overall, amifostine and cysteamine showed scavenging activity as potent as natural antioxidants. We found a correlation between scavenging activity and radioprotective efficiency that was previously determined in rat thymocytes. These correlations are indicative that natural antioxidants can be effective radioprotectors.</description><subject>Antioxidants</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cysteamine</subject><subject>Diagnostic Radiology</subject><subject>Free radicals</subject><subject>Free radicals (Chemistry)</subject><subject>Hadrons</subject><subject>Heavy Ions</subject><subject>Inorganic Chemistry</subject><subject>Nuclear Chemistry</subject><subject>Nuclear Physics</subject><subject>Physical Chemistry</subject><subject>Radiation</subject><subject>Radiolysis</subject><subject>Scavenging</subject><subject>Vitamin E</subject><issn>0236-5731</issn><issn>1588-2780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU9rlDEQxoNYcN32C3gKeE6dJO-fvN5KsVUo9KLnkDeZLCnvJmuSre7Nj262K5SKyBwGZp7fzDAPIe84XHKA8UPhMA0jAwEMRtErNr4iK94rxcSo4DVZgZAD60fJ35C3pTwAwKSUXJFfNxmRZeOCNQst1jxi3IS4ocbW8BjqgSZPj-20y6mirSmXj9Sm7c7kUFKkM9YfiJHaJcTjjOVA9wXd3ww10dFo6j63NSbWkH4G13I5J2feLAUv_uQ1-Xbz6ev1Z3Z3f_vl-uqOWamGyvzQCynN6MHbwXSeS5hE18vZWQX9PHfT0M0KJ6dAeAWSO-O98h32Dhyik2vy_jS33fR9j6Xqh7TPsa3Uomsfm3qQ07NqYxbUIfpUs7HbUKy-GmR7L-dNtyaX_1C1cLgNNkX0odVfAOIE2JxKyej1LoetyQfNQR8N1CcDdQP0k4F6bJA8QaWJ4wbz88X_oX4DeC2glA</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Sueishi, Yoshimi</creator><creator>Fujii, Takumi</creator><creator>Nii, Risako</creator><general>Springer International Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200801</creationdate><title>Free-radical scavenging activity of radioprotectors: comparison between clinically used radioprotectors and natural antioxidants</title><author>Sueishi, Yoshimi ; Fujii, Takumi ; Nii, Risako</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f65233a7f0fc6a4f13092453bdc805bb4964b8e9d802f8031daff8f4e5d0deed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antioxidants</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cysteamine</topic><topic>Diagnostic Radiology</topic><topic>Free radicals</topic><topic>Free radicals (Chemistry)</topic><topic>Hadrons</topic><topic>Heavy Ions</topic><topic>Inorganic Chemistry</topic><topic>Nuclear Chemistry</topic><topic>Nuclear Physics</topic><topic>Physical Chemistry</topic><topic>Radiation</topic><topic>Radiolysis</topic><topic>Scavenging</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sueishi, Yoshimi</creatorcontrib><creatorcontrib>Fujii, Takumi</creatorcontrib><creatorcontrib>Nii, Risako</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sueishi, Yoshimi</au><au>Fujii, Takumi</au><au>Nii, Risako</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Free-radical scavenging activity of radioprotectors: comparison between clinically used radioprotectors and natural antioxidants</atitle><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle><stitle>J Radioanal Nucl Chem</stitle><date>2020-08-01</date><risdate>2020</risdate><volume>325</volume><issue>2</issue><spage>695</spage><epage>700</epage><pages>695-700</pages><issn>0236-5731</issn><eissn>1588-2780</eissn><abstract>Clinically used radioprotectors, amifostine and cysteamine, have been shown to possess free-radical scavenging activities. 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| subjects | Antioxidants Chemistry Chemistry and Materials Science Cysteamine Diagnostic Radiology Free radicals Free radicals (Chemistry) Hadrons Heavy Ions Inorganic Chemistry Nuclear Chemistry Nuclear Physics Physical Chemistry Radiation Radiolysis Scavenging Vitamin E |
| title | Free-radical scavenging activity of radioprotectors: comparison between clinically used radioprotectors and natural antioxidants |
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