PTEN/PI3K/VEGF signaling pathway involved in the protective effect of xanthine oxidase inhibitor febuxostat against endometrial hyperplasia in rats

Endometrial hyperplasia (EH) is a medical condition that affects many females as it increases their uterine carcinogenic potential. EH results from entangling hormonal imbalance and inflammatory response. The study examined the role of a xanthine oxidase inhibitor, febuxostat, in a rat model of EH....

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Veröffentlicht in:	Human & experimental toxicology 2020-09, Vol.39 (9), p.1224-1234
Hauptverfasser:	Mohamed, MZ, Baky, MF Abed El, Hassan, OA, Mohammed, HH, Abdel-Aziz, AM
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 17β-Estradiol AKT protein Animal models Animals Carcinogens Endometrial Hyperplasia - drug therapy Endometrium Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Enzyme-linked immunosorbent assay Epithelium Estradiol Estrogens Febuxostat - pharmacology Febuxostat - therapeutic use Female Glutathione Growth factors Histopathology Homology Hyperplasia Hypoxia Hypoxia-inducible factor 1 Hypoxia-inducible factor 1a Hypoxia-inducible factors Inflammation Inflammatory response Interleukin 6 Kinases Malondialdehyde Oxidative Stress - drug effects Phosphatidylinositol 3-Kinase - metabolism Polymerase chain reaction PTEN Phosphohydrolase - metabolism PTEN protein Rats Rats, Wistar Restoration Sex hormones Signal transduction Signal Transduction - drug effects Superoxide dismutase Tensin Uterus Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Xanthine oxidase Xanthine Oxidase - antagonists & inhibitors
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