Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the intracellular microenvironment, which is under the constitutive control of glutathione peroxidase 4 (GPX4). Ferrous iron (Fe2+) accumulation and lipid peroxidation are critical events in the induction of ferr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2020-07, Vol.483, p.127-136
Hauptverfasser:	Su, Yanwei, Zhao, Bin, Zhou, Liangfu, Zhang, Zheyuan, Shen, Ying, Lv, Huanhuan, AlQudsy, Luban Hamdy Hameed, Shang, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Alcohol Amino acids Animals Antineoplastic Agents - therapeutic use Antioxidants Apoptosis Artesunate Autophagy Cancer Cancer therapies Cell death Cell proliferation Chelating agents Cisplatin Drug development Fatty acids Ferritinophagy Ferroptosis Ferroptosis - drug effects Fibroblasts Free radicals Glutathione peroxidase Glutathione peroxidase 4 Humans Iron Lipid peroxidation Lipid Peroxidation - drug effects Lipids Lipophilic Metabolism Mitochondria Morphology Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Oxidation Oxidative Stress - drug effects Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Roles Salinomycin Signal Transduction Sulfasalazine System xc Tumor Microenvironment Vitamin E
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!