Quantitative trait loci in ABCA1 modify cerebrospinal fluid amyloid-β1-42 and plasma apolipoprotein levels

The ATP-binding cassette transporter A1 encoded by ABCA1 plays an integral role in the efflux of cellular cholesterol and phospholipids, but may also be a central mediator of β-amyloid (Aβ) processing. Here, genetic association of the common R219K variant of ABCA1 is shown with cerebrospinal fluid (...

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Veröffentlicht in:	Journal of human genetics 2006-03, Vol.51 (3), p.171-179
Hauptverfasser:	Katzov, Hagit, Bennet, Anna M., Höglund, Kina, Wiman, Björn, Lütjohann, Dieter, Brookes, Anthony J., Andreasen, Niels, Blennow, Kaj, De Faire, Ulf, Prince, Jonathan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 protein Alzheimer's disease Apolipoprotein A Apolipoprotein B Apolipoproteins ATP-binding protein Biomedicine Cerebrospinal fluid Cholesterol Gene Expression Gene Function Gene Therapy Genetic markers Genotypes High density lipoprotein Human Genetics Lipid metabolism Low density lipoprotein Metabolism Molecular Medicine Original Article Phenotypes Phospholipids Quantitative trait loci Smoking β-Amyloid
Online-Zugang:	Volltext
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