A high-throughput SNP typing system for genome-wide association studies

One of the most difficult issues to be solved in genome-wide association studies is to reduce the amount of genomic DNA required for genotyping. Currently available technologies require too large a quantity of genomic DNA to genotype with hundreds or thousands of single-nucleotide polymorphisms (SNP...

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Veröffentlicht in:	Journal of human genetics 2001-08, Vol.46 (8), p.471-477
Hauptverfasser:	Ohnishi, Y, Tanaka, T, Ozaki, K, Yamada, R, Suzuki, H, Nakamura, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Deoxyribonucleic acid DNA Energy Transfer - genetics Fluorescent Dyes - analysis Gene Amplification Genetic Markers Genome, Human Genome-wide association studies Genomes Genotype Genotyping Humans Polymerase chain reaction Polymerase Chain Reaction - economics Polymerase Chain Reaction - instrumentation Polymerase Chain Reaction - methods Polymorphism, Single Nucleotide - genetics Reproducibility of Results Single-nucleotide polymorphism Taq Polymerase - metabolism
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