Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers
Expression of genes in the Rb-E2F signaling pathway is controlled by E2F transcriptional factors originally defined as molecules that bind to the promoter of E2 adenovirus. The E2F gene family consists of six members and is designated E2F1–6. The Rb-E2F signaling pathway is among the main regulators...
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| Veröffentlicht in: | Journal of human genetics 2004-06, Vol.49 (6), p.312-318 |
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| creator | Onda, Masamitsu Nagai, Hisaki Yoshida, Akira Miyamoto, Shizuyo Asaka, Shin-ichi Akaishi, Junko Takatsu, Keisuke Nagahama, Mitsuji Ito, Kouichi Shimizu, Kazuo Emi, Mitsuru |
| description | Expression of genes in the Rb-E2F signaling pathway is controlled by E2F transcriptional factors originally defined as molecules that bind to the promoter of E2 adenovirus. The E2F gene family consists of six members and is designated E2F1–6. The Rb-E2F signaling pathway is among the main regulators of the cell cycle, hence its importance in differentiation and oncogenesis. We document here up-regulation of
E2F1
, but not other members of the E2F gene family, in 15 of 18 primary papillary thyroid cancers examined (83%) in comparison to corresponding noncancerous thyroid tissues and in all of 11 anaplastic thyroid cancer (ATC) cell lines (100%). The
E2F4
gene, however, was down-regulated in 12 of the papillary thyroid cancers (67%). Immunohistochemical analysis with antibody to
E2F1
revealed prominent intracellular
E2F1
protein in most of the primary papillary cancers (16 of 18; 89%) but was not detectable in normal thyroid tissues. These data indicated that increased expression of the
E2F1
gene might play a significant role in human thyroid carcinogenesis through derangement of the Rb-E2F signaling pathway. |
| doi_str_mv | 10.1007/s10038-004-0146-3 |
| format | Article |
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E2F1
, but not other members of the E2F gene family, in 15 of 18 primary papillary thyroid cancers examined (83%) in comparison to corresponding noncancerous thyroid tissues and in all of 11 anaplastic thyroid cancer (ATC) cell lines (100%). The
E2F4
gene, however, was down-regulated in 12 of the papillary thyroid cancers (67%). Immunohistochemical analysis with antibody to
E2F1
revealed prominent intracellular
E2F1
protein in most of the primary papillary cancers (16 of 18; 89%) but was not detectable in normal thyroid tissues. These data indicated that increased expression of the
E2F1
gene might play a significant role in human thyroid carcinogenesis through derangement of the Rb-E2F signaling pathway.</description><identifier>ISSN: 1434-5161</identifier><identifier>EISSN: 1435-232X</identifier><identifier>DOI: 10.1007/s10038-004-0146-3</identifier><identifier>PMID: 15118916</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Biomedicine ; Carcinogenesis ; Carcinoma - genetics ; Carcinoma - metabolism ; Carcinoma, Papillary - genetics ; Carcinoma, Papillary - metabolism ; Cell cycle ; Cell Cycle Proteins ; Cell Differentiation ; Cell Line, Tumor ; DNA Primers - chemistry ; DNA, Complementary - metabolism ; DNA-Binding Proteins - biosynthesis ; DNA-Binding Proteins - genetics ; E2F gene ; E2F Transcription Factors ; E2F1 gene ; E2F1 protein ; E2F1 Transcription Factor ; E2F4 gene ; E2F4 Transcription Factor ; Female ; Gene Expression ; Gene Function ; Gene regulation ; Gene Therapy ; Human Genetics ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Molecular Medicine ; Retinoblastoma Protein - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; RNA - chemistry ; RNA, Messenger - metabolism ; Short Communication ; Signal Transduction ; Thyroid cancer ; Thyroid gland ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - metabolism ; Transcription factors ; Transcription Factors - biosynthesis ; Transcription Factors - genetics ; Tumor cell lines ; Tumorigenesis ; Up-Regulation</subject><ispartof>Journal of human genetics, 2004-06, Vol.49 (6), p.312-318</ispartof><rights>The Japan Society of Human Genetics and Springer-Verlag 2004</rights><rights>The Japan Society of Human Genetics and Springer-Verlag 2004.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-ff23a55c6e2bb0ba33567148424b72198cf5ffc096bcf3275751a899a909980f3</citedby><cites>FETCH-LOGICAL-c484t-ff23a55c6e2bb0ba33567148424b72198cf5ffc096bcf3275751a899a909980f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10038-004-0146-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10038-004-0146-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15118916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Onda, Masamitsu</creatorcontrib><creatorcontrib>Nagai, Hisaki</creatorcontrib><creatorcontrib>Yoshida, Akira</creatorcontrib><creatorcontrib>Miyamoto, Shizuyo</creatorcontrib><creatorcontrib>Asaka, Shin-ichi</creatorcontrib><creatorcontrib>Akaishi, Junko</creatorcontrib><creatorcontrib>Takatsu, Keisuke</creatorcontrib><creatorcontrib>Nagahama, Mitsuji</creatorcontrib><creatorcontrib>Ito, Kouichi</creatorcontrib><creatorcontrib>Shimizu, Kazuo</creatorcontrib><creatorcontrib>Emi, Mitsuru</creatorcontrib><title>Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers</title><title>Journal of human genetics</title><addtitle>J Hum Genet</addtitle><addtitle>J Hum Genet</addtitle><description>Expression of genes in the Rb-E2F signaling pathway is controlled by E2F transcriptional factors originally defined as molecules that bind to the promoter of E2 adenovirus. The E2F gene family consists of six members and is designated E2F1–6. The Rb-E2F signaling pathway is among the main regulators of the cell cycle, hence its importance in differentiation and oncogenesis. We document here up-regulation of
E2F1
, but not other members of the E2F gene family, in 15 of 18 primary papillary thyroid cancers examined (83%) in comparison to corresponding noncancerous thyroid tissues and in all of 11 anaplastic thyroid cancer (ATC) cell lines (100%). The
E2F4
gene, however, was down-regulated in 12 of the papillary thyroid cancers (67%). Immunohistochemical analysis with antibody to
E2F1
revealed prominent intracellular
E2F1
protein in most of the primary papillary cancers (16 of 18; 89%) but was not detectable in normal thyroid tissues. These data indicated that increased expression of the
E2F1
gene might play a significant role in human thyroid carcinogenesis through derangement of the Rb-E2F signaling pathway.</description><subject>Adult</subject><subject>Biomedicine</subject><subject>Carcinogenesis</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma, Papillary - genetics</subject><subject>Carcinoma, Papillary - metabolism</subject><subject>Cell cycle</subject><subject>Cell Cycle Proteins</subject><subject>Cell Differentiation</subject><subject>Cell Line, Tumor</subject><subject>DNA Primers - chemistry</subject><subject>DNA, Complementary - metabolism</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>DNA-Binding Proteins - genetics</subject><subject>E2F gene</subject><subject>E2F Transcription Factors</subject><subject>E2F1 gene</subject><subject>E2F1 protein</subject><subject>E2F1 Transcription Factor</subject><subject>E2F4 gene</subject><subject>E2F4 Transcription Factor</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Function</subject><subject>Gene regulation</subject><subject>Gene Therapy</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Retinoblastoma Protein - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA - chemistry</subject><subject>RNA, Messenger - metabolism</subject><subject>Short Communication</subject><subject>Signal Transduction</subject><subject>Thyroid cancer</subject><subject>Thyroid gland</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Transcription factors</subject><subject>Transcription Factors - biosynthesis</subject><subject>Transcription Factors - genetics</subject><subject>Tumor cell lines</subject><subject>Tumorigenesis</subject><subject>Up-Regulation</subject><issn>1434-5161</issn><issn>1435-232X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kEtPxCAUhYnR-Bj9AW6UxDXK5dGWpZmMj2QSN5q4I5SBsZPaVqCL-fcydqI7F8AN9zuHy0HoEugtUFrexbzzilAqCAVREH6ATkFwSRhn74c_tSASCjhBZzFuaKZZyY7RCUiASkFxit7fBhLcemxNavoO9x6nYLpoQzPsLkyLvbGpD3jBHgA3HR7M0LStCVtsulVeZmhNTI3F6WMb-maFremsC_EcHXnTRnexP2fo7WHxOn8iy5fH5_n9klhRiUS8Z9xIaQvH6prWhnNZlJBbTNQlA1VZL723VBW19Xl6WUowlVJGUaUq6vkM3Uy-Q-i_RheT3vRjyINHzQSTBSgueKZgomzoYwzO6yE0n_kXGqjeZamnLHXOUu-y1DvN1d55rD_d6k-xDy8DbAJibnVrF_6e_s_1ehJ1Jo3B_bpuPtYsY5Lxb7RHiN0</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Onda, Masamitsu</creator><creator>Nagai, Hisaki</creator><creator>Yoshida, Akira</creator><creator>Miyamoto, Shizuyo</creator><creator>Asaka, Shin-ichi</creator><creator>Akaishi, Junko</creator><creator>Takatsu, Keisuke</creator><creator>Nagahama, Mitsuji</creator><creator>Ito, Kouichi</creator><creator>Shimizu, Kazuo</creator><creator>Emi, Mitsuru</creator><general>Springer Japan</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope></search><sort><creationdate>20040601</creationdate><title>Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers</title><author>Onda, Masamitsu ; Nagai, Hisaki ; Yoshida, Akira ; Miyamoto, Shizuyo ; Asaka, Shin-ichi ; Akaishi, Junko ; Takatsu, Keisuke ; Nagahama, Mitsuji ; Ito, Kouichi ; Shimizu, Kazuo ; Emi, Mitsuru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-ff23a55c6e2bb0ba33567148424b72198cf5ffc096bcf3275751a899a909980f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Biomedicine</topic><topic>Carcinogenesis</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma, Papillary - genetics</topic><topic>Carcinoma, Papillary - metabolism</topic><topic>Cell cycle</topic><topic>Cell Cycle Proteins</topic><topic>Cell Differentiation</topic><topic>Cell Line, Tumor</topic><topic>DNA Primers - chemistry</topic><topic>DNA, Complementary - metabolism</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>DNA-Binding Proteins - genetics</topic><topic>E2F gene</topic><topic>E2F Transcription Factors</topic><topic>E2F1 gene</topic><topic>E2F1 protein</topic><topic>E2F1 Transcription Factor</topic><topic>E2F4 gene</topic><topic>E2F4 Transcription Factor</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gene Function</topic><topic>Gene regulation</topic><topic>Gene Therapy</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Retinoblastoma Protein - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA - chemistry</topic><topic>RNA, Messenger - metabolism</topic><topic>Short Communication</topic><topic>Signal Transduction</topic><topic>Thyroid cancer</topic><topic>Thyroid gland</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Transcription factors</topic><topic>Transcription Factors - biosynthesis</topic><topic>Transcription Factors - genetics</topic><topic>Tumor cell lines</topic><topic>Tumorigenesis</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Onda, Masamitsu</creatorcontrib><creatorcontrib>Nagai, Hisaki</creatorcontrib><creatorcontrib>Yoshida, Akira</creatorcontrib><creatorcontrib>Miyamoto, Shizuyo</creatorcontrib><creatorcontrib>Asaka, Shin-ichi</creatorcontrib><creatorcontrib>Akaishi, Junko</creatorcontrib><creatorcontrib>Takatsu, Keisuke</creatorcontrib><creatorcontrib>Nagahama, Mitsuji</creatorcontrib><creatorcontrib>Ito, Kouichi</creatorcontrib><creatorcontrib>Shimizu, Kazuo</creatorcontrib><creatorcontrib>Emi, Mitsuru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><jtitle>Journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Onda, Masamitsu</au><au>Nagai, Hisaki</au><au>Yoshida, Akira</au><au>Miyamoto, Shizuyo</au><au>Asaka, Shin-ichi</au><au>Akaishi, Junko</au><au>Takatsu, Keisuke</au><au>Nagahama, Mitsuji</au><au>Ito, Kouichi</au><au>Shimizu, Kazuo</au><au>Emi, Mitsuru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers</atitle><jtitle>Journal of human genetics</jtitle><stitle>J Hum Genet</stitle><addtitle>J Hum Genet</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>49</volume><issue>6</issue><spage>312</spage><epage>318</epage><pages>312-318</pages><issn>1434-5161</issn><eissn>1435-232X</eissn><abstract>Expression of genes in the Rb-E2F signaling pathway is controlled by E2F transcriptional factors originally defined as molecules that bind to the promoter of E2 adenovirus. The E2F gene family consists of six members and is designated E2F1–6. The Rb-E2F signaling pathway is among the main regulators of the cell cycle, hence its importance in differentiation and oncogenesis. We document here up-regulation of
E2F1
, but not other members of the E2F gene family, in 15 of 18 primary papillary thyroid cancers examined (83%) in comparison to corresponding noncancerous thyroid tissues and in all of 11 anaplastic thyroid cancer (ATC) cell lines (100%). The
E2F4
gene, however, was down-regulated in 12 of the papillary thyroid cancers (67%). Immunohistochemical analysis with antibody to
E2F1
revealed prominent intracellular
E2F1
protein in most of the primary papillary cancers (16 of 18; 89%) but was not detectable in normal thyroid tissues. These data indicated that increased expression of the
E2F1
gene might play a significant role in human thyroid carcinogenesis through derangement of the Rb-E2F signaling pathway.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>15118916</pmid><doi>10.1007/s10038-004-0146-3</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of human genetics, 2004-06, Vol.49 (6), p.312-318 |
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| subjects | Adult Biomedicine Carcinogenesis Carcinoma - genetics Carcinoma - metabolism Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Cell cycle Cell Cycle Proteins Cell Differentiation Cell Line, Tumor DNA Primers - chemistry DNA, Complementary - metabolism DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics E2F gene E2F Transcription Factors E2F1 gene E2F1 protein E2F1 Transcription Factor E2F4 gene E2F4 Transcription Factor Female Gene Expression Gene Function Gene regulation Gene Therapy Human Genetics Humans Immunohistochemistry Male Middle Aged Molecular Medicine Retinoblastoma Protein - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry RNA, Messenger - metabolism Short Communication Signal Transduction Thyroid cancer Thyroid gland Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Transcription factors Transcription Factors - biosynthesis Transcription Factors - genetics Tumor cell lines Tumorigenesis Up-Regulation |
| title | Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers |
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