No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population

Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1, also known as PC-1) inhibits insulin signal transduction pathway(s). Previous studies have demonstrated the K121Q variant of the ENPP1 gene to have a significant functional role in determining susceptibility to insulin resistance and type 2...

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Veröffentlicht in:	Journal of human genetics 2006-06, Vol.51 (6), p.559-566
Hauptverfasser:	Keshavarz, Parvaneh, Inoue, Hiroshi, Sakamoto, Yukiko, Kunika, Kiyoshi, Tanahashi, Toshihito, Nakamura, Naoto, Yoshikawa, Toshikazu, Yasui, Natsuo, Shiota, Hiroshi, Itakura, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans African Americans - genetics Alleles Amino Acid Substitution Asian Continental Ancestry Group - genetics Biomedicine Case-Control Studies Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics European Continental Ancestry Group - genetics Female Gene Expression Gene Frequency Gene Function Gene Therapy Genetic distance Genetic Variation Genotypes Human Genetics Humans Insulin Insulin resistance Insulin Resistance - genetics Japan Male Molecular Medicine Original Article Phosphodiesterase Phosphoric Diester Hydrolases - genetics Pyrophosphatase Pyrophosphatases - genetics Risk Factors Signal transduction
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