Dysregulated Brain Cholesterol Metabolism Is Linked to Neuroinflammation in Huntington's Disease

ABSTRACT Huntington's disease is an autosomal‐dominant, neurodegenerative disorder caused by a CAG repeat expansion in exon‐1 of the huntingtin gene. Alterations in cholesterol metabolism and distribution have been reported in Huntington's disease, including abnormal interactions between m...

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Veröffentlicht in:	Movement disorders 2020-07, Vol.35 (7), p.1113-1127
Hauptverfasser:	González‐Guevara, Edith, Cárdenas, Graciela, Pérez‐Severiano, Francisca, Martínez‐Lazcano, Juan Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 Apolipoprotein E Astrocytes ATP Binding Cassette Transporter 1 - metabolism Atrophy Brain - metabolism Caudate nucleus Cell adhesion & migration Cell migration Cholesterol Cholesterol - metabolism Hereditary diseases Humans Huntingtin Huntington Disease - genetics Huntington Disease - metabolism Huntington's disease Huntingtons disease Immunosuppressive agents Inflammation Lipid Metabolism Metabolism Movement disorders Mutants Neurodegenerative diseases Plasma levels Polyglutamine Proteins Receptor density SREBP statins Sterols Trinucleotide repeat diseases Trinucleotide repeats
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