Efficacy of a Bruton's Tyrosine Kinase Inhibitor (PRN‐473) in the treatment of canine pemphigus foliaceus

Background Bruton's tyrosine kinase (BTK) is important in B‐cell signalling. Efficacy has been reported for BTK inhibitors (BTKi) in human autoimmune diseases. Canine pemphigus foliaceus (cPF) is the most common canine autoimmune skin disease. Objectives To determine the safety and efficacy of...

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Veröffentlicht in:	Veterinary dermatology 2020-08, Vol.31 (4), p.291-e71
Hauptverfasser:	Goodale, Elizabeth C., Varjonen, Katarina E., Outerbridge, Catherine A., Bizikova, Petra, Borjesson, Dori, Murrell, Dedee F., Bisconte, Angelina, Francesco, Michelle, Hill, Ronald J., Masjedizadeh, Mohammad, Nunn, Philip, Gourlay, Steven G., White, Stephen D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - blood Autoimmune diseases Bruton's tyrosine kinase Desmocollin Disease Dog Diseases - drug therapy Dog Diseases - immunology Dogs Dosage Enzyme inhibitors Female Immunoglobulin G Immunoglobulin G - blood Leukocytes (mononuclear) Male Pemphigus Pemphigus - drug therapy Pemphigus - veterinary Peripheral blood mononuclear cells Pilot Projects Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - therapeutic use Remission Skin diseases Tumors Tyrosine kinase inhibitors
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