Integrative analyses of gene expression profile reveal potential crucial roles of mitotic cell cycle and microtubule cytoskeleton in pulmonary artery hypertension

Background Pulmonary arterial hypertension (PAH) is a life-threatening condition. The aim of this study was to explore potential crucial genes and pathways associated with PAH based on integrative analyses of gene expression and to shed light on the identification of biomarker for PAH. Methods Gene...

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Veröffentlicht in:	BMC medical genomics 2020-06, Vol.13 (1), p.86-86, Article 86
Hauptverfasser:	Luo, Jing, Li, Haiyan, Liu, Zhenwei, Li, Chenlu, Wang, Ruochen, Fang, Jinxia, Lu, Saisai, Guo, Jing, Zhu, Xiaochun, Wang, Xiaobing
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biomarkers Bone morphogenetic proteins Case-Control Studies Cell Cycle Computational Biology Cytoskeleton Cytoskeleton - genetics Cytoskeleton - metabolism Datasets Differentially expressed gene Disease Functional enrichment analysis Gene expression Gene Expression Profiling Gene Expression Regulation Genes Genetic aspects Genetic engineering Genetics & Heredity Humans Hypertension Identification Life Sciences & Biomedicine MicroRNA MicroRNAs MicroRNAs - genetics Microtubules - genetics Microtubules - metabolism miRNAs Mitosis Ontology Phenotypes Principal components analysis Protein interaction Protein Interaction Maps Protein-protein interaction network Protein-protein interactions Pulmonary arterial hypertension Pulmonary Arterial Hypertension - genetics Pulmonary Arterial Hypertension - metabolism Pulmonary Arterial Hypertension - pathology Pulmonary arteries Pulmonary artery Pulmonary Artery - metabolism Pulmonary Artery - pathology Pulmonary hypertension Science & Technology Signal transduction Software packages Transcriptome Transcriptomics Transforming growth factors
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