Assessing patient‐reported symptom burden of long‐term head and neck cancer survivors at annual surveillance in survivorship clinic
Background This study reports long‐term head and neck cancer (HNC) patient‐reported symptoms using the MD Anderson Symptom Inventory Head and Neck Cancer Module (MDASI‐HN) in a large cohort of HNC survivors. Methods MDASI‐HN results were prospectively collected from an institutional survivorship dat...
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| Veröffentlicht in: | Head & neck 2020-08, Vol.42 (8), p.1919-1927 |
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| container_title | Head & neck |
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| creator | Townes, Thomas G. Navuluri, Sriram Pytynia, Kristen B. Gunn, Gary Brandon Kamal, Mona J. Gilmore, Katherine R. Chapman, Patricia H. Bell, Katherine V. Fournier, Danielle M. Janik, Monica A. Joseph, Liza M. Zendehdel, Sara Hutcheson, Katherine A. Goepfert, Ryan P. |
| description | Background
This study reports long‐term head and neck cancer (HNC) patient‐reported symptoms using the MD Anderson Symptom Inventory Head and Neck Cancer Module (MDASI‐HN) in a large cohort of HNC survivors.
Methods
MDASI‐HN results were prospectively collected from an institutional survivorship database. Associations with clinicopathologic data were analyzed using χ2, Mann‐Whitney, and univariate regression.
Results
Nine hundred and twenty‐eight patients were included. Forty‐six percent had oropharyngeal primary tumors. Eighty‐two percent had squamous cell carcinoma. Fifty‐six percent of patients had ablative surgery and 81% had radiation therapy as a component of treatment. The most severe symptoms were xerostomia and dysphagia. Symptom scores were worst for hypopharynx and varied by subsite. Patients treated with chemoradiation or surgery followed by radiation ± chemotherapy reported the worst symptoms while patient treated with surgery plus radiation ± chemotherapy reported the worst interference.
Conclusion
HNC survivors describe their long‐term symptom burden and inform efforts to improve care many years into survivorship. |
| doi_str_mv | 10.1002/hed.26119 |
| format | Article |
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This study reports long‐term head and neck cancer (HNC) patient‐reported symptoms using the MD Anderson Symptom Inventory Head and Neck Cancer Module (MDASI‐HN) in a large cohort of HNC survivors.
Methods
MDASI‐HN results were prospectively collected from an institutional survivorship database. Associations with clinicopathologic data were analyzed using χ2, Mann‐Whitney, and univariate regression.
Results
Nine hundred and twenty‐eight patients were included. Forty‐six percent had oropharyngeal primary tumors. Eighty‐two percent had squamous cell carcinoma. Fifty‐six percent of patients had ablative surgery and 81% had radiation therapy as a component of treatment. The most severe symptoms were xerostomia and dysphagia. Symptom scores were worst for hypopharynx and varied by subsite. Patients treated with chemoradiation or surgery followed by radiation ± chemotherapy reported the worst symptoms while patient treated with surgery plus radiation ± chemotherapy reported the worst interference.
Conclusion
HNC survivors describe their long‐term symptom burden and inform efforts to improve care many years into survivorship.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26119</identifier><identifier>PMID: 32112621</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Cancer therapies ; Chemoradiotherapy ; Chemotherapy ; Dysphagia ; Head & neck cancer ; Hypopharynx ; Patients ; Radiation therapy ; Squamous cell carcinoma ; Surgery ; Survival ; Tumors ; Xerostomia</subject><ispartof>Head & neck, 2020-08, Vol.42 (8), p.1919-1927</ispartof><rights>2020 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-cafae404085d435756862e9cc04eefa8672ec62ee518ec6e93a2b26dde1495123</citedby><cites>FETCH-LOGICAL-c3539-cafae404085d435756862e9cc04eefa8672ec62ee518ec6e93a2b26dde1495123</cites><orcidid>0000-0003-1626-2657 ; 0000-0002-3291-841X ; 0000-0003-3710-5706</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.26119$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.26119$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32112621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Townes, Thomas G.</creatorcontrib><creatorcontrib>Navuluri, Sriram</creatorcontrib><creatorcontrib>Pytynia, Kristen B.</creatorcontrib><creatorcontrib>Gunn, Gary Brandon</creatorcontrib><creatorcontrib>Kamal, Mona J.</creatorcontrib><creatorcontrib>Gilmore, Katherine R.</creatorcontrib><creatorcontrib>Chapman, Patricia H.</creatorcontrib><creatorcontrib>Bell, Katherine V.</creatorcontrib><creatorcontrib>Fournier, Danielle M.</creatorcontrib><creatorcontrib>Janik, Monica A.</creatorcontrib><creatorcontrib>Joseph, Liza M.</creatorcontrib><creatorcontrib>Zendehdel, Sara</creatorcontrib><creatorcontrib>Hutcheson, Katherine A.</creatorcontrib><creatorcontrib>Goepfert, Ryan P.</creatorcontrib><title>Assessing patient‐reported symptom burden of long‐term head and neck cancer survivors at annual surveillance in survivorship clinic</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
This study reports long‐term head and neck cancer (HNC) patient‐reported symptoms using the MD Anderson Symptom Inventory Head and Neck Cancer Module (MDASI‐HN) in a large cohort of HNC survivors.
Methods
MDASI‐HN results were prospectively collected from an institutional survivorship database. Associations with clinicopathologic data were analyzed using χ2, Mann‐Whitney, and univariate regression.
Results
Nine hundred and twenty‐eight patients were included. Forty‐six percent had oropharyngeal primary tumors. Eighty‐two percent had squamous cell carcinoma. Fifty‐six percent of patients had ablative surgery and 81% had radiation therapy as a component of treatment. The most severe symptoms were xerostomia and dysphagia. Symptom scores were worst for hypopharynx and varied by subsite. Patients treated with chemoradiation or surgery followed by radiation ± chemotherapy reported the worst symptoms while patient treated with surgery plus radiation ± chemotherapy reported the worst interference.
Conclusion
HNC survivors describe their long‐term symptom burden and inform efforts to improve care many years into survivorship.</description><subject>Cancer therapies</subject><subject>Chemoradiotherapy</subject><subject>Chemotherapy</subject><subject>Dysphagia</subject><subject>Head & neck cancer</subject><subject>Hypopharynx</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><subject>Survival</subject><subject>Tumors</subject><subject>Xerostomia</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kL1OwzAUhS0EoqUw8ALIEhNDWv8lacaqFIpUiQXmyHVuWpfECXZS1I2NlWfkSXD_xMR0j8797rnSQeiakj4lhA2WkPVZRGlygrqUJHFAuIhPt1rwgJNYdNCFcytCCI8EO0cdzihlEaNd9DVyDpzTZoFr2Wgwzc_nt4W6sg1k2G3KuqlKPG9tBgZXOS4qs_BEA7bES5AZlibDBtQbVtIosNi1dq3XlXVYNn5pWlnsPNBFsSWwNn_MUtdYFdpodYnOclk4uDrMHnp9mLyMp8Hs-fFpPJoFioc8CZTMJQgiyDDMBA_jMBpGDBKliADI5TCKGSjvQEiHXkDCJZuzKMuAiiSkjPfQ7T63ttV7C65JV1VrjX-ZMsFEJPyh8NTdnlK2cs5CntZWl9JuUkrSbeWprzzdVe7Zm0NiOy-9eySPHXtgsAc-dAGb_5PS6eR-H_kLCF-PaQ</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Townes, Thomas G.</creator><creator>Navuluri, Sriram</creator><creator>Pytynia, Kristen B.</creator><creator>Gunn, Gary Brandon</creator><creator>Kamal, Mona J.</creator><creator>Gilmore, Katherine R.</creator><creator>Chapman, Patricia H.</creator><creator>Bell, Katherine V.</creator><creator>Fournier, Danielle M.</creator><creator>Janik, Monica A.</creator><creator>Joseph, Liza M.</creator><creator>Zendehdel, Sara</creator><creator>Hutcheson, Katherine A.</creator><creator>Goepfert, Ryan P.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-1626-2657</orcidid><orcidid>https://orcid.org/0000-0002-3291-841X</orcidid><orcidid>https://orcid.org/0000-0003-3710-5706</orcidid></search><sort><creationdate>202008</creationdate><title>Assessing patient‐reported symptom burden of long‐term head and neck cancer survivors at annual surveillance in survivorship clinic</title><author>Townes, Thomas G. ; Navuluri, Sriram ; Pytynia, Kristen B. ; Gunn, Gary Brandon ; Kamal, Mona J. ; Gilmore, Katherine R. ; Chapman, Patricia H. ; Bell, Katherine V. ; Fournier, Danielle M. ; Janik, Monica A. ; Joseph, Liza M. ; Zendehdel, Sara ; Hutcheson, Katherine A. ; Goepfert, Ryan P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-cafae404085d435756862e9cc04eefa8672ec62ee518ec6e93a2b26dde1495123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cancer therapies</topic><topic>Chemoradiotherapy</topic><topic>Chemotherapy</topic><topic>Dysphagia</topic><topic>Head & neck cancer</topic><topic>Hypopharynx</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><topic>Survival</topic><topic>Tumors</topic><topic>Xerostomia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Townes, Thomas G.</creatorcontrib><creatorcontrib>Navuluri, Sriram</creatorcontrib><creatorcontrib>Pytynia, Kristen B.</creatorcontrib><creatorcontrib>Gunn, Gary Brandon</creatorcontrib><creatorcontrib>Kamal, Mona J.</creatorcontrib><creatorcontrib>Gilmore, Katherine R.</creatorcontrib><creatorcontrib>Chapman, Patricia H.</creatorcontrib><creatorcontrib>Bell, Katherine V.</creatorcontrib><creatorcontrib>Fournier, Danielle M.</creatorcontrib><creatorcontrib>Janik, Monica A.</creatorcontrib><creatorcontrib>Joseph, Liza M.</creatorcontrib><creatorcontrib>Zendehdel, Sara</creatorcontrib><creatorcontrib>Hutcheson, Katherine A.</creatorcontrib><creatorcontrib>Goepfert, Ryan P.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Townes, Thomas G.</au><au>Navuluri, Sriram</au><au>Pytynia, Kristen B.</au><au>Gunn, Gary Brandon</au><au>Kamal, Mona J.</au><au>Gilmore, Katherine R.</au><au>Chapman, Patricia H.</au><au>Bell, Katherine V.</au><au>Fournier, Danielle M.</au><au>Janik, Monica A.</au><au>Joseph, Liza M.</au><au>Zendehdel, Sara</au><au>Hutcheson, Katherine A.</au><au>Goepfert, Ryan P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing patient‐reported symptom burden of long‐term head and neck cancer survivors at annual surveillance in survivorship clinic</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2020-08</date><risdate>2020</risdate><volume>42</volume><issue>8</issue><spage>1919</spage><epage>1927</epage><pages>1919-1927</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
This study reports long‐term head and neck cancer (HNC) patient‐reported symptoms using the MD Anderson Symptom Inventory Head and Neck Cancer Module (MDASI‐HN) in a large cohort of HNC survivors.
Methods
MDASI‐HN results were prospectively collected from an institutional survivorship database. Associations with clinicopathologic data were analyzed using χ2, Mann‐Whitney, and univariate regression.
Results
Nine hundred and twenty‐eight patients were included. Forty‐six percent had oropharyngeal primary tumors. Eighty‐two percent had squamous cell carcinoma. Fifty‐six percent of patients had ablative surgery and 81% had radiation therapy as a component of treatment. The most severe symptoms were xerostomia and dysphagia. Symptom scores were worst for hypopharynx and varied by subsite. Patients treated with chemoradiation or surgery followed by radiation ± chemotherapy reported the worst symptoms while patient treated with surgery plus radiation ± chemotherapy reported the worst interference.
Conclusion
HNC survivors describe their long‐term symptom burden and inform efforts to improve care many years into survivorship.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32112621</pmid><doi>10.1002/hed.26119</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1626-2657</orcidid><orcidid>https://orcid.org/0000-0002-3291-841X</orcidid><orcidid>https://orcid.org/0000-0003-3710-5706</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Cancer therapies Chemoradiotherapy Chemotherapy Dysphagia Head & neck cancer Hypopharynx Patients Radiation therapy Squamous cell carcinoma Surgery Survival Tumors Xerostomia |
| title | Assessing patient‐reported symptom burden of long‐term head and neck cancer survivors at annual surveillance in survivorship clinic |
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