The effect of adenosine triphosphate on sunitinib-induced cardiac injury in rats

In this study, we aimed to show the effect of adenosine 5′-triphosphate (ATP) on sunitinib-induced cardiac injury in rats. The rats (n = 30) were divided equally into three groups as sunitinib group (SG), sunitinib plus ATP group (SAG), and healthy group (HG); 2 mg/kg ATP was injected intraperitonea...

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Veröffentlicht in:	Human & experimental toxicology 2020-08, Vol.39 (8), p.1046-1053
Hauptverfasser:	Aldemir, MN, Simsek, M, Kara, AV, Ozcicek, F, Mammadov, R, Yazıcı, GN, Sunar, M, Coskun, R, Gulaboglu, M, Suleyman, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Adenosine Triphosphate - pharmacology Adenosine Triphosphate - therapeutic use Animal tissues Animals Antineoplastic Agents - toxicity ATP Blood vessels Calcium-binding protein Cardiac muscle Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Cardiotoxicity - blood Cardiotoxicity - drug therapy Cardiotoxicity - metabolism Cardiotoxins - toxicity Catheters Glutathione Glutathione - metabolism Inhibitor drugs Male Malondialdehyde Malondialdehyde - metabolism Medical instruments Morphology Muscles Myocardium - metabolism Myocardium - pathology NF-kappa B - metabolism NF-κB protein Protein Kinase Inhibitors - toxicity Rats, Wistar Sunitinib - toxicity Targeted cancer therapy Troponin Troponin I Troponin I - blood Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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