Multifunctional Ag/polymer composite nanospheres for drug delivery and cell imaging
Judicious combination of noble metals and smart gels makes cell imaging and drug delivery into one, which provides support for the integrated technology of diagnosis and treatment. In this work, the Ag nanoparticles (Ag NPs)/poly-( N -isopropylacrylamide-co-dimethylaminoethylmethacrylate) core–shell...
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| Veröffentlicht in: | Journal of materials science 2020-10, Vol.55 (28), p.13995-14007 |
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| container_end_page | 14007 |
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| container_issue | 28 |
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| container_title | Journal of materials science |
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| creator | Wang, Yang Gao, Doudou Zhou, Dong Li, Yulin Wang, Xianxun He, Peixin Zhang, Yuhong |
| description | Judicious combination of noble metals and smart gels makes cell imaging and drug delivery into one, which provides support for the integrated technology of diagnosis and treatment. In this work, the Ag nanoparticles (Ag NPs)/poly-(
N
-isopropylacrylamide-co-dimethylaminoethylmethacrylate) core–shell multifunctional composite nanosphere (Ag–p (NIPAM-co-DMAEMA)) was successfully synthesized by two-step one-pot method. The composite nanospheres had a particle size of approximately 200 nm and possessed multiple sensitive release properties, biocompatibility, and pharmacological activity. Importantly, it was found that cancer cells (CT-26) uptake more hybrid gels and exhibited stronger fluorescence, compared to normal cells (COS-7). This indicated that the hybrid gel had certain specificity and could be used for the imaging of cancer cells. Multifunctional composite nanospheres with optical and therapeutic functionality constructed by a simple method offered broad opportunities for cancer treatment and cell imaging. |
| doi_str_mv | 10.1007/s10853-020-04912-z |
| format | Article |
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N
-isopropylacrylamide-co-dimethylaminoethylmethacrylate) core–shell multifunctional composite nanosphere (Ag–p (NIPAM-co-DMAEMA)) was successfully synthesized by two-step one-pot method. The composite nanospheres had a particle size of approximately 200 nm and possessed multiple sensitive release properties, biocompatibility, and pharmacological activity. Importantly, it was found that cancer cells (CT-26) uptake more hybrid gels and exhibited stronger fluorescence, compared to normal cells (COS-7). This indicated that the hybrid gel had certain specificity and could be used for the imaging of cancer cells. Multifunctional composite nanospheres with optical and therapeutic functionality constructed by a simple method offered broad opportunities for cancer treatment and cell imaging.</description><identifier>ISSN: 0022-2461</identifier><identifier>EISSN: 1573-4803</identifier><identifier>DOI: 10.1007/s10853-020-04912-z</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biocompatibility ; Cancer ; Characterization and Evaluation of Materials ; Chemistry and Materials Science ; Classical Mechanics ; Comparative analysis ; Crystallography and Scattering Methods ; Drug delivery systems ; Drugs ; Fluorescence ; Gels ; Isopropylacrylamide ; Materials for Life Sciences ; Materials Science ; Medical imaging ; Nanoparticles ; Nanospheres ; Noble metals ; Polymer matrix composites ; Polymer Sciences ; Silver ; Solid Mechanics ; Vehicles</subject><ispartof>Journal of materials science, 2020-10, Vol.55 (28), p.13995-14007</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-c682d0170016da4ccc5fbdda67c311c8efbb4a2bc3a419af42d9a9ca50e3cf0e3</citedby><cites>FETCH-LOGICAL-c420t-c682d0170016da4ccc5fbdda67c311c8efbb4a2bc3a419af42d9a9ca50e3cf0e3</cites><orcidid>0000-0003-3643-1403</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10853-020-04912-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10853-020-04912-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Wang, Yang</creatorcontrib><creatorcontrib>Gao, Doudou</creatorcontrib><creatorcontrib>Zhou, Dong</creatorcontrib><creatorcontrib>Li, Yulin</creatorcontrib><creatorcontrib>Wang, Xianxun</creatorcontrib><creatorcontrib>He, Peixin</creatorcontrib><creatorcontrib>Zhang, Yuhong</creatorcontrib><title>Multifunctional Ag/polymer composite nanospheres for drug delivery and cell imaging</title><title>Journal of materials science</title><addtitle>J Mater Sci</addtitle><description>Judicious combination of noble metals and smart gels makes cell imaging and drug delivery into one, which provides support for the integrated technology of diagnosis and treatment. In this work, the Ag nanoparticles (Ag NPs)/poly-(
N
-isopropylacrylamide-co-dimethylaminoethylmethacrylate) core–shell multifunctional composite nanosphere (Ag–p (NIPAM-co-DMAEMA)) was successfully synthesized by two-step one-pot method. The composite nanospheres had a particle size of approximately 200 nm and possessed multiple sensitive release properties, biocompatibility, and pharmacological activity. Importantly, it was found that cancer cells (CT-26) uptake more hybrid gels and exhibited stronger fluorescence, compared to normal cells (COS-7). This indicated that the hybrid gel had certain specificity and could be used for the imaging of cancer cells. Multifunctional composite nanospheres with optical and therapeutic functionality constructed by a simple method offered broad opportunities for cancer treatment and cell imaging.</description><subject>Biocompatibility</subject><subject>Cancer</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry and Materials Science</subject><subject>Classical Mechanics</subject><subject>Comparative analysis</subject><subject>Crystallography and Scattering Methods</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Fluorescence</subject><subject>Gels</subject><subject>Isopropylacrylamide</subject><subject>Materials for Life Sciences</subject><subject>Materials Science</subject><subject>Medical imaging</subject><subject>Nanoparticles</subject><subject>Nanospheres</subject><subject>Noble metals</subject><subject>Polymer matrix composites</subject><subject>Polymer Sciences</subject><subject>Silver</subject><subject>Solid Mechanics</subject><subject>Vehicles</subject><issn>0022-2461</issn><issn>1573-4803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kV1LHDEUhoO04Nb2D_Qq0CsvRk--5uNyEauCIlS9Dtl8TCMzyTSZKa6_3ugWZEHKgRwIzxN48yL0ncAJAWhOM4FWsAooVMA7QqvnA7QiomEVb4F9QisASivKa3KIvuT8CACioWSF7m6WYfZuCXr2MagBr_vTKQ7b0Sas4zjF7GeLgwoxT79tshm7mLBJS4-NHfxfm7ZYBYO1HQbsR9X70H9Fn50asv32bx-hh5_n92eX1fXtxdXZ-rrSnMJc6bqlBkgDQGqjuNZauI0xqm40I0S31m02XNGNZoqTTjlOTac6rQRYpl05jtCP3btTin8Wm2f5GJdUQmRJOWW14B0V71SvBit9cHFOSo8-a7muaSdYK3hTqJMPqDLGjl7HYJ0v93vC8Z5QmNk-zb1acpZXd7_2WbpjdYo5J-vklMpfpa0kIF_7k7v-ZOlPvvUnn4vEdlIucOhtek_3H-sFz3udxA</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Wang, Yang</creator><creator>Gao, Doudou</creator><creator>Zhou, Dong</creator><creator>Li, Yulin</creator><creator>Wang, Xianxun</creator><creator>He, Peixin</creator><creator>Zhang, Yuhong</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><orcidid>https://orcid.org/0000-0003-3643-1403</orcidid></search><sort><creationdate>20201001</creationdate><title>Multifunctional Ag/polymer composite nanospheres for drug delivery and cell imaging</title><author>Wang, Yang ; Gao, Doudou ; Zhou, Dong ; Li, Yulin ; Wang, Xianxun ; He, Peixin ; Zhang, Yuhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-c682d0170016da4ccc5fbdda67c311c8efbb4a2bc3a419af42d9a9ca50e3cf0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biocompatibility</topic><topic>Cancer</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry and Materials Science</topic><topic>Classical Mechanics</topic><topic>Comparative analysis</topic><topic>Crystallography and Scattering Methods</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Fluorescence</topic><topic>Gels</topic><topic>Isopropylacrylamide</topic><topic>Materials for Life Sciences</topic><topic>Materials Science</topic><topic>Medical imaging</topic><topic>Nanoparticles</topic><topic>Nanospheres</topic><topic>Noble metals</topic><topic>Polymer matrix composites</topic><topic>Polymer Sciences</topic><topic>Silver</topic><topic>Solid Mechanics</topic><topic>Vehicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yang</creatorcontrib><creatorcontrib>Gao, Doudou</creatorcontrib><creatorcontrib>Zhou, Dong</creatorcontrib><creatorcontrib>Li, Yulin</creatorcontrib><creatorcontrib>Wang, Xianxun</creatorcontrib><creatorcontrib>He, Peixin</creatorcontrib><creatorcontrib>Zhang, Yuhong</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><jtitle>Journal of materials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yang</au><au>Gao, Doudou</au><au>Zhou, Dong</au><au>Li, Yulin</au><au>Wang, Xianxun</au><au>He, Peixin</au><au>Zhang, Yuhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multifunctional Ag/polymer composite nanospheres for drug delivery and cell imaging</atitle><jtitle>Journal of materials science</jtitle><stitle>J Mater Sci</stitle><date>2020-10-01</date><risdate>2020</risdate><volume>55</volume><issue>28</issue><spage>13995</spage><epage>14007</epage><pages>13995-14007</pages><issn>0022-2461</issn><eissn>1573-4803</eissn><abstract>Judicious combination of noble metals and smart gels makes cell imaging and drug delivery into one, which provides support for the integrated technology of diagnosis and treatment. In this work, the Ag nanoparticles (Ag NPs)/poly-(
N
-isopropylacrylamide-co-dimethylaminoethylmethacrylate) core–shell multifunctional composite nanosphere (Ag–p (NIPAM-co-DMAEMA)) was successfully synthesized by two-step one-pot method. The composite nanospheres had a particle size of approximately 200 nm and possessed multiple sensitive release properties, biocompatibility, and pharmacological activity. Importantly, it was found that cancer cells (CT-26) uptake more hybrid gels and exhibited stronger fluorescence, compared to normal cells (COS-7). This indicated that the hybrid gel had certain specificity and could be used for the imaging of cancer cells. Multifunctional composite nanospheres with optical and therapeutic functionality constructed by a simple method offered broad opportunities for cancer treatment and cell imaging.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10853-020-04912-z</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-3643-1403</orcidid></addata></record> |
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| subjects | Biocompatibility Cancer Characterization and Evaluation of Materials Chemistry and Materials Science Classical Mechanics Comparative analysis Crystallography and Scattering Methods Drug delivery systems Drugs Fluorescence Gels Isopropylacrylamide Materials for Life Sciences Materials Science Medical imaging Nanoparticles Nanospheres Noble metals Polymer matrix composites Polymer Sciences Silver Solid Mechanics Vehicles |
| title | Multifunctional Ag/polymer composite nanospheres for drug delivery and cell imaging |
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