Response Patterns of Biomarkers as Tools to Identify Toxic Effects of Cadmium and Lead on Bufo gargarizans Embryo
Molecular biomarkers play an increasing crucial role in evaluating and predicting toxicity of metals. Expressions patterns of genes related to oxidative stress, apoptosis, immune and inflammation response in the Bufo gargarizans embryo exhibited a development dependent manner. The genes related to o...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 2020-07, Vol.105 (1), p.41-50 |
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| creator | Zheng, Rui Wu, Minyao Wang, Hongyuan Peng, Jufang |
| description | Molecular biomarkers play an increasing crucial role in evaluating and predicting toxicity of metals. Expressions patterns of genes related to oxidative stress, apoptosis, immune and inflammation response in the
Bufo gargarizans
embryo exhibited a development dependent manner. The genes related to oxidative stress (HSP, GPx and SOD) are the first response in the development of embryo, followed by the apoptosis (Bax, BCLAF1 and TRAIL) and inflammation and immune response (SOCS3, IL-27 and IL-17D), respectively. Then, we have verified the HSP, Bax and SOCS3 IL-27 (expressed highest in their respective processes) exhibited the most significant changes in Cd–Pb mixed group compared with control. In addition, we found exposure of Cd–Pb mixed metals causes greater adverse effects than Cd, Pb alone on development and morphology of embryo. Overall, our results provide a useful tool to use the sensitive molecular biomarkers as indicators of developmental toxicity in amphibian embryo. |
| doi_str_mv | 10.1007/s00128-020-02884-z |
| format | Article |
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Bufo gargarizans
embryo exhibited a development dependent manner. The genes related to oxidative stress (HSP, GPx and SOD) are the first response in the development of embryo, followed by the apoptosis (Bax, BCLAF1 and TRAIL) and inflammation and immune response (SOCS3, IL-27 and IL-17D), respectively. Then, we have verified the HSP, Bax and SOCS3 IL-27 (expressed highest in their respective processes) exhibited the most significant changes in Cd–Pb mixed group compared with control. In addition, we found exposure of Cd–Pb mixed metals causes greater adverse effects than Cd, Pb alone on development and morphology of embryo. Overall, our results provide a useful tool to use the sensitive molecular biomarkers as indicators of developmental toxicity in amphibian embryo.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/s00128-020-02884-z</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Apoptosis ; Aquatic Pollution ; Biomarkers ; Bufo gargarizans ; Cadmium ; Earth and Environmental Science ; Ecotoxicology ; Embryos ; Environment ; Environmental Chemistry ; Environmental Health ; Genes ; Heavy metals ; Immune response ; Immune system ; Interleukin 27 ; Lead ; Morphology ; Oxidative stress ; Pollution ; Soil Science & Conservation ; Toads ; Toxicity ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Bulletin of environmental contamination and toxicology, 2020-07, Vol.105 (1), p.41-50</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-fff8f48140fc830b1c5bc0db258e9e34f6dce054f80beeea374120ffb24e98063</citedby><cites>FETCH-LOGICAL-c352t-fff8f48140fc830b1c5bc0db258e9e34f6dce054f80beeea374120ffb24e98063</cites><orcidid>0000-0001-7025-2404</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00128-020-02884-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00128-020-02884-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Zheng, Rui</creatorcontrib><creatorcontrib>Wu, Minyao</creatorcontrib><creatorcontrib>Wang, Hongyuan</creatorcontrib><creatorcontrib>Peng, Jufang</creatorcontrib><title>Response Patterns of Biomarkers as Tools to Identify Toxic Effects of Cadmium and Lead on Bufo gargarizans Embryo</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><description>Molecular biomarkers play an increasing crucial role in evaluating and predicting toxicity of metals. Expressions patterns of genes related to oxidative stress, apoptosis, immune and inflammation response in the
Bufo gargarizans
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Overall, our results provide a useful tool to use the sensitive molecular biomarkers as indicators of developmental toxicity in amphibian embryo.</description><subject>Apoptosis</subject><subject>Aquatic Pollution</subject><subject>Biomarkers</subject><subject>Bufo gargarizans</subject><subject>Cadmium</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Embryos</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Genes</subject><subject>Heavy metals</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Interleukin 27</subject><subject>Lead</subject><subject>Morphology</subject><subject>Oxidative stress</subject><subject>Pollution</subject><subject>Soil Science & Conservation</subject><subject>Toads</subject><subject>Toxicity</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE9LAzEQxYMoWKtfwFPA8-rkz27Toy1VCwVF6jlks5Oytd20yS7YfnpjV_AmzDAw_N4b5hFyy-CeAYweIgDjKgMOqZWS2fGMDJgUPAMFcE4GkKhMqoJdkqsY1wnPFecDsn_HuPNNRPpm2hZDE6l3dFL7rQmfGCI1kS6930TaejqvsGlrd0ibr9rSmXNo25Ngaqpt3W2paSq6QFNR39BJ5zxdmZCqPppkPNuW4eCvyYUzm4g3v3NIPp5my-lLtnh9nk8fF5kVOW8z55xyUjEJzioBJbN5aaEqea5wjEK6orIIuXQKSkQ0YiQZB-dKLnGsoBBDctf77oLfdxhbvfZdaNJJzSUXRS64hETxnrLBxxjQ6V2o0-8HzUD_RKv7aHWKVp-i1cckEr0oJrhZYfiz_kf1DfjNfYw</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Zheng, Rui</creator><creator>Wu, Minyao</creator><creator>Wang, Hongyuan</creator><creator>Peng, Jufang</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TK</scope><scope>7TV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0001-7025-2404</orcidid></search><sort><creationdate>20200701</creationdate><title>Response Patterns of Biomarkers as Tools to Identify Toxic Effects of Cadmium and Lead on Bufo gargarizans Embryo</title><author>Zheng, Rui ; Wu, Minyao ; Wang, Hongyuan ; Peng, Jufang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-fff8f48140fc830b1c5bc0db258e9e34f6dce054f80beeea374120ffb24e98063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>Aquatic Pollution</topic><topic>Biomarkers</topic><topic>Bufo gargarizans</topic><topic>Cadmium</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Embryos</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Genes</topic><topic>Heavy metals</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Interleukin 27</topic><topic>Lead</topic><topic>Morphology</topic><topic>Oxidative stress</topic><topic>Pollution</topic><topic>Soil Science & Conservation</topic><topic>Toads</topic><topic>Toxicity</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Rui</creatorcontrib><creatorcontrib>Wu, Minyao</creatorcontrib><creatorcontrib>Wang, Hongyuan</creatorcontrib><creatorcontrib>Peng, Jufang</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><jtitle>Bulletin of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Rui</au><au>Wu, Minyao</au><au>Wang, Hongyuan</au><au>Peng, Jufang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response Patterns of Biomarkers as Tools to Identify Toxic Effects of Cadmium and Lead on Bufo gargarizans Embryo</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><stitle>Bull Environ Contam Toxicol</stitle><date>2020-07-01</date><risdate>2020</risdate><volume>105</volume><issue>1</issue><spage>41</spage><epage>50</epage><pages>41-50</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><abstract>Molecular biomarkers play an increasing crucial role in evaluating and predicting toxicity of metals. Expressions patterns of genes related to oxidative stress, apoptosis, immune and inflammation response in the
Bufo gargarizans
embryo exhibited a development dependent manner. The genes related to oxidative stress (HSP, GPx and SOD) are the first response in the development of embryo, followed by the apoptosis (Bax, BCLAF1 and TRAIL) and inflammation and immune response (SOCS3, IL-27 and IL-17D), respectively. Then, we have verified the HSP, Bax and SOCS3 IL-27 (expressed highest in their respective processes) exhibited the most significant changes in Cd–Pb mixed group compared with control. In addition, we found exposure of Cd–Pb mixed metals causes greater adverse effects than Cd, Pb alone on development and morphology of embryo. Overall, our results provide a useful tool to use the sensitive molecular biomarkers as indicators of developmental toxicity in amphibian embryo.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00128-020-02884-z</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7025-2404</orcidid></addata></record> |
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| subjects | Apoptosis Aquatic Pollution Biomarkers Bufo gargarizans Cadmium Earth and Environmental Science Ecotoxicology Embryos Environment Environmental Chemistry Environmental Health Genes Heavy metals Immune response Immune system Interleukin 27 Lead Morphology Oxidative stress Pollution Soil Science & Conservation Toads Toxicity Waste Water Technology Water Management Water Pollution Control |
| title | Response Patterns of Biomarkers as Tools to Identify Toxic Effects of Cadmium and Lead on Bufo gargarizans Embryo |
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