Dicationic Amino Substituted Gemini Surfactants and their Nanoplexes: Improved Synthesis and Characterization of Transfection Efficiency and Corneal Penetration In Vitro

Purpose To formulate and characterize nanoparticles from m-7NH-m gemini surfactants, synthesized by a new improved method, for non-invasive gene delivery including optimization of composition for transfection efficiency and corneal penetration. Methods A one-pot, solvent-free, DMAP-free method was d...

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Veröffentlicht in:	Pharmaceutical research 2020-07, Vol.37 (7), p.144, Article 144
Hauptverfasser:	Narsineni, Lokesh, Foldvari, Marianna
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Ophthalmic Analysis Animals Astrocytes Astrocytes - metabolism Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Cell Line Confocal microscopy Cornea Cornea - metabolism DNA - administration & dosage DNA - chemistry Drug Compounding Efficiency Flow cytometry Gene Expression Gene therapy Gene transfer Gene Transfer Techniques Genes Genetic Therapy Impurities Infection Light scattering Lipid Based Drug Delivery Magnetic resonance spectroscopy Medical Law Nanoparticles NMR Nuclear magnetic resonance Nuclear magnetic resonance spectroscopy Pharmacology/Toxicology Pharmacy Phosphatidylethanolamines - chemistry Plasmids - chemistry Rats Research Paper Surface active agents Surface-Active Agents - chemistry Surface-Active Agents - pharmacokinetics Surface-Active Agents - pharmacology Surfactants Toxicity Transfection Zeta potential
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