Design of a new electrochemical sensing system based on MoS2–TiO2/reduced graphene oxide nanocomposite for the detection of paracetamol
Herein, we designed a new electrochemical sensor (MoS2–TiO2/rGO/SPE) based on a molybdenum disulfide (MoS2)–titanium dioxide (TiO2)/reduced graphene oxide (rGO) nanocomposite-modified screen printed electrode (SPE) for the selective and sensitive detection of paracetamol (acetaminophen, Ac). This de...
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| Veröffentlicht in: | New journal of chemistry 2020-07, Vol.44 (27), p.11759-11767 |
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| container_title | New journal of chemistry |
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| creator | Demir, Neslihan Atacan, Keziban Ozmen, Mustafa Bas, Salih Zeki |
| description | Herein, we designed a new electrochemical sensor (MoS2–TiO2/rGO/SPE) based on a molybdenum disulfide (MoS2)–titanium dioxide (TiO2)/reduced graphene oxide (rGO) nanocomposite-modified screen printed electrode (SPE) for the selective and sensitive detection of paracetamol (acetaminophen, Ac). This design was optimized by examining the effect of the rGO : MoS2–TiO2 ratio, MoS2–TiO2/rGO composite amount on the SPE, and pH of the electrolyte on the current signal of the fabricated sensor towards the oxidation of Ac. MoS2–TiO2/rGO/SPE showed linearity in the range of 0.1 μM to 125 μM with a high sensitivity of 0.4425 μA μM−1. The detection limit (LOD) was found to be 0.046 μM. To test the applicability of MoS2–TiO2/rGO/SPE for practical analysis, a few drops of drug and human urine samples were directly applied on the surface of the fabricated sensor for measuring Ac after dilution of the samples with 0.1 M phosphate buffer solution (pH 7.4). Furthermore, the specificity of MoS2–TiO2/rGO/SPE was evaluated by monitoring the current changes in the presence of possible interferents in biological fluids. |
| doi_str_mv | 10.1039/d0nj02298e |
| format | Article |
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This design was optimized by examining the effect of the rGO : MoS2–TiO2 ratio, MoS2–TiO2/rGO composite amount on the SPE, and pH of the electrolyte on the current signal of the fabricated sensor towards the oxidation of Ac. MoS2–TiO2/rGO/SPE showed linearity in the range of 0.1 μM to 125 μM with a high sensitivity of 0.4425 μA μM−1. The detection limit (LOD) was found to be 0.046 μM. To test the applicability of MoS2–TiO2/rGO/SPE for practical analysis, a few drops of drug and human urine samples were directly applied on the surface of the fabricated sensor for measuring Ac after dilution of the samples with 0.1 M phosphate buffer solution (pH 7.4). Furthermore, the specificity of MoS2–TiO2/rGO/SPE was evaluated by monitoring the current changes in the presence of possible interferents in biological fluids.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/d0nj02298e</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Analgesics ; Buffer solutions ; Chemical sensors ; Design optimization ; Dilution ; Graphene ; Linearity ; Mapping ; Molybdenum disulfide ; Nanocomposites ; Oxidation ; Sensors ; Titanium ; Titanium dioxide</subject><ispartof>New journal of chemistry, 2020-07, Vol.44 (27), p.11759-11767</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Demir, Neslihan</creatorcontrib><creatorcontrib>Atacan, Keziban</creatorcontrib><creatorcontrib>Ozmen, Mustafa</creatorcontrib><creatorcontrib>Bas, Salih Zeki</creatorcontrib><title>Design of a new electrochemical sensing system based on MoS2–TiO2/reduced graphene oxide nanocomposite for the detection of paracetamol</title><title>New journal of chemistry</title><description>Herein, we designed a new electrochemical sensor (MoS2–TiO2/rGO/SPE) based on a molybdenum disulfide (MoS2)–titanium dioxide (TiO2)/reduced graphene oxide (rGO) nanocomposite-modified screen printed electrode (SPE) for the selective and sensitive detection of paracetamol (acetaminophen, Ac). This design was optimized by examining the effect of the rGO : MoS2–TiO2 ratio, MoS2–TiO2/rGO composite amount on the SPE, and pH of the electrolyte on the current signal of the fabricated sensor towards the oxidation of Ac. MoS2–TiO2/rGO/SPE showed linearity in the range of 0.1 μM to 125 μM with a high sensitivity of 0.4425 μA μM−1. The detection limit (LOD) was found to be 0.046 μM. To test the applicability of MoS2–TiO2/rGO/SPE for practical analysis, a few drops of drug and human urine samples were directly applied on the surface of the fabricated sensor for measuring Ac after dilution of the samples with 0.1 M phosphate buffer solution (pH 7.4). Furthermore, the specificity of MoS2–TiO2/rGO/SPE was evaluated by monitoring the current changes in the presence of possible interferents in biological fluids.</description><subject>Analgesics</subject><subject>Buffer solutions</subject><subject>Chemical sensors</subject><subject>Design optimization</subject><subject>Dilution</subject><subject>Graphene</subject><subject>Linearity</subject><subject>Mapping</subject><subject>Molybdenum disulfide</subject><subject>Nanocomposites</subject><subject>Oxidation</subject><subject>Sensors</subject><subject>Titanium</subject><subject>Titanium dioxide</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNotjT9PwzAUxC0EEqWw8AksMYc-P6dOPKLyVyrqQJkrx35pUzV2iF0BGysz35BPQgTohjvdSfdj7FzApQCpJw78FhB1SQdsJKTSmUYlDocs8jyDaa6O2UmMWwAhCiVG7POaYrP2PNTccE-vnHZkUx_shtrGmh2P5GPj1zy-x0Qtr0wkx4Pnj-EJvz--ls0CJz25vR3qdW-6DXni4a1xxL3xwYa2C7FJxOvQ87Qh7igNhCb8MjvTG0vJtGF3yo5qs4t09u9j9nx7s5zdZ_PF3cPsap51opQps4WyuUKjC1CyrqwygzQKB1NEB-CMdCUYLLUpKqslYp1XqhZQWBSUoxyzi7_frg8ve4pptQ373g_IFQ4zqCmUKH8Awh5l_g</recordid><startdate>20200721</startdate><enddate>20200721</enddate><creator>Demir, Neslihan</creator><creator>Atacan, Keziban</creator><creator>Ozmen, Mustafa</creator><creator>Bas, Salih Zeki</creator><general>Royal Society of Chemistry</general><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope></search><sort><creationdate>20200721</creationdate><title>Design of a new electrochemical sensing system based on MoS2–TiO2/reduced graphene oxide nanocomposite for the detection of paracetamol</title><author>Demir, Neslihan ; Atacan, Keziban ; Ozmen, Mustafa ; Bas, Salih Zeki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p183t-c76c462a97063fbc6a6a6921d0522d00da3d80a289a7bc9322f4b6f107c21e423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analgesics</topic><topic>Buffer solutions</topic><topic>Chemical sensors</topic><topic>Design optimization</topic><topic>Dilution</topic><topic>Graphene</topic><topic>Linearity</topic><topic>Mapping</topic><topic>Molybdenum disulfide</topic><topic>Nanocomposites</topic><topic>Oxidation</topic><topic>Sensors</topic><topic>Titanium</topic><topic>Titanium dioxide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demir, Neslihan</creatorcontrib><creatorcontrib>Atacan, Keziban</creatorcontrib><creatorcontrib>Ozmen, Mustafa</creatorcontrib><creatorcontrib>Bas, Salih Zeki</creatorcontrib><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demir, Neslihan</au><au>Atacan, Keziban</au><au>Ozmen, Mustafa</au><au>Bas, Salih Zeki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design of a new electrochemical sensing system based on MoS2–TiO2/reduced graphene oxide nanocomposite for the detection of paracetamol</atitle><jtitle>New journal of chemistry</jtitle><date>2020-07-21</date><risdate>2020</risdate><volume>44</volume><issue>27</issue><spage>11759</spage><epage>11767</epage><pages>11759-11767</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>Herein, we designed a new electrochemical sensor (MoS2–TiO2/rGO/SPE) based on a molybdenum disulfide (MoS2)–titanium dioxide (TiO2)/reduced graphene oxide (rGO) nanocomposite-modified screen printed electrode (SPE) for the selective and sensitive detection of paracetamol (acetaminophen, Ac). This design was optimized by examining the effect of the rGO : MoS2–TiO2 ratio, MoS2–TiO2/rGO composite amount on the SPE, and pH of the electrolyte on the current signal of the fabricated sensor towards the oxidation of Ac. MoS2–TiO2/rGO/SPE showed linearity in the range of 0.1 μM to 125 μM with a high sensitivity of 0.4425 μA μM−1. The detection limit (LOD) was found to be 0.046 μM. To test the applicability of MoS2–TiO2/rGO/SPE for practical analysis, a few drops of drug and human urine samples were directly applied on the surface of the fabricated sensor for measuring Ac after dilution of the samples with 0.1 M phosphate buffer solution (pH 7.4). Furthermore, the specificity of MoS2–TiO2/rGO/SPE was evaluated by monitoring the current changes in the presence of possible interferents in biological fluids.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d0nj02298e</doi><tpages>9</tpages></addata></record> |
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| ispartof | New journal of chemistry, 2020-07, Vol.44 (27), p.11759-11767 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Analgesics Buffer solutions Chemical sensors Design optimization Dilution Graphene Linearity Mapping Molybdenum disulfide Nanocomposites Oxidation Sensors Titanium Titanium dioxide |
| title | Design of a new electrochemical sensing system based on MoS2–TiO2/reduced graphene oxide nanocomposite for the detection of paracetamol |
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