Transcriptional regulator SpxA1a controls the resistance of the honey bee pathogen Melissococcus plutonius to the antimicrobial activity of royal jelly

Summary Royal jelly (RJ), a brood food of honey bees, has strong antimicrobial activity. Melissococcus plutonius, the causative agent of European foulbrood of honey bees, exhibits resistance to this antimicrobial activity and infects larvae orally. Among three genetically distinct groups (CC3, CC12...

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Veröffentlicht in:	Environmental microbiology 2020-07, Vol.22 (7), p.2736-2755
Hauptverfasser:	Takamatsu, Daisuke, Okumura, Kayo, Tabata, Atsushi, Okamoto, Mariko, Okura, Masatoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Antimicrobial resistance Apis mellifera Bees Bees - microbiology Colonies Disease resistance Drug Resistance, Bacterial - genetics Enterococcaceae - drug effects Enterococcaceae - genetics European foulbrood Fatty Acids - chemistry Fatty Acids - pharmacology Fatty Acids, Monounsaturated - pharmacology Frameshift Mutation Gene Deletion Genes Genomes Honey Larva - microbiology Larvae Melissococcus plutonius Mutagenesis Mutants Mutation Nucleotide sequence Oxidative stress Oxidoreductase Oxidoreductases Pathogens Proteins Reductases Royal jelly Sequence analysis Stress proteins Superoxide dismutase Transcription Ultraviolet Rays
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