Synthesis, antimicrobial and antioxidant activity of bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl) methane
A series of new bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl)methane 3(a–d)/5(a–f) were synthesized from bis‐(4‐aminophenyl)methane (1) using various pharmacologically active sulfonyl chlorides 2(a–d) and carbonochloridates 4(a–f) in high yields. The structures of all the newly synthe...
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| Veröffentlicht in: | Journal of the Chinese Chemical Society (Taipei) 2020-07, Vol.67 (7), p.1289-1295 |
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| container_title | Journal of the Chinese Chemical Society (Taipei) |
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| creator | Nagalakshmamma, Vadabingi Varalakshmi, Mavallur Umapriya, Kollu Venkataswamy, Mallepogu Venkataramaiah, Chintha Thyaga Raju, Kedam Chalapathi, Ponne Venkata NagaRaju, Chamarthi |
| description | A series of new bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl)methane 3(a–d)/5(a–f) were synthesized from bis‐(4‐aminophenyl)methane (1) using various pharmacologically active sulfonyl chlorides 2(a–d) and carbonochloridates 4(a–f) in high yields. The structures of all the newly synthesized compounds were characterized by the Infrared spectroscopy, NMR (1H and 13C), mass, and elemental analyses. Further, all the synthesized compounds were tested for the antioxidant activity by using 2, 2‐diphenyl‐1‐picrylhydrazyl, NO, and H2O2 scavenging methods and antimicrobial activity. Most of the compounds exhibited good antioxidant and antimicrobial activities. |
| doi_str_mv | 10.1002/jccs.201900434 |
| format | Article |
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The structures of all the newly synthesized compounds were characterized by the Infrared spectroscopy, NMR (1H and 13C), mass, and elemental analyses. Further, all the synthesized compounds were tested for the antioxidant activity by using 2, 2‐diphenyl‐1‐picrylhydrazyl, NO, and H2O2 scavenging methods and antimicrobial activity. Most of the compounds exhibited good antioxidant and antimicrobial activities.</description><identifier>ISSN: 0009-4536</identifier><identifier>EISSN: 2192-6549</identifier><identifier>DOI: 10.1002/jccs.201900434</identifier><language>eng</language><publisher>Weinheim: Wiley‐VCH Verlag GmbH & Co. KGaA</publisher><subject>Antiinfectives and antibacterials ; antimicrobial activity ; Antimicrobial agents ; antioxidant activity ; Antioxidants ; bis‐(4‐aminophenyl) methane ; carbonyl chloridates ; Derivatives ; Hydrogen peroxide ; Infrared analysis ; Methane ; NMR ; Nuclear magnetic resonance ; Scavenging ; Sulfonamides ; sulfonyl chlorides ; Synthesis</subject><ispartof>Journal of the Chinese Chemical Society (Taipei), 2020-07, Vol.67 (7), p.1289-1295</ispartof><rights>2020 The Chemical Society Located in Taipei & Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3544-1ce738f7d3110cc7e3bf151acc9db612d49e7f29531fe56580b19115a19f98ee3</citedby><cites>FETCH-LOGICAL-c3544-1ce738f7d3110cc7e3bf151acc9db612d49e7f29531fe56580b19115a19f98ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjccs.201900434$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjccs.201900434$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Nagalakshmamma, Vadabingi</creatorcontrib><creatorcontrib>Varalakshmi, Mavallur</creatorcontrib><creatorcontrib>Umapriya, Kollu</creatorcontrib><creatorcontrib>Venkataswamy, Mallepogu</creatorcontrib><creatorcontrib>Venkataramaiah, Chintha</creatorcontrib><creatorcontrib>Thyaga Raju, Kedam</creatorcontrib><creatorcontrib>Chalapathi, Ponne Venkata</creatorcontrib><creatorcontrib>NagaRaju, Chamarthi</creatorcontrib><title>Synthesis, antimicrobial and antioxidant activity of bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl) methane</title><title>Journal of the Chinese Chemical Society (Taipei)</title><description>A series of new bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl)methane 3(a–d)/5(a–f) were synthesized from bis‐(4‐aminophenyl)methane (1) using various pharmacologically active sulfonyl chlorides 2(a–d) and carbonochloridates 4(a–f) in high yields. The structures of all the newly synthesized compounds were characterized by the Infrared spectroscopy, NMR (1H and 13C), mass, and elemental analyses. Further, all the synthesized compounds were tested for the antioxidant activity by using 2, 2‐diphenyl‐1‐picrylhydrazyl, NO, and H2O2 scavenging methods and antimicrobial activity. Most of the compounds exhibited good antioxidant and antimicrobial activities.</description><subject>Antiinfectives and antibacterials</subject><subject>antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>bis‐(4‐aminophenyl) methane</subject><subject>carbonyl chloridates</subject><subject>Derivatives</subject><subject>Hydrogen peroxide</subject><subject>Infrared analysis</subject><subject>Methane</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Scavenging</subject><subject>Sulfonamides</subject><subject>sulfonyl chlorides</subject><subject>Synthesis</subject><issn>0009-4536</issn><issn>2192-6549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkE1Lw0AQhhdRsFavngNeFEy7n0n3KMFPCh6q52WzmaVb8lGzaTUHwZ_gb_SXuLVFj15mmOF5Z-BB6JTgEcGYjhfG-BHFRGLMGd9DA0okjRPB5T4aYIxlzAVLDtGR94sNQoUcoPdZX3dz8M5fRrruXOVM2-ROl2EqfjbNmytCj7Tp3Np1fdTYKHc-8qvSNrWuXAFjo9tcV7qDqIDWrXUgwe_Ar4_Pcx5KIOtmOYe6Ly-iCrq5ruEYHVhdejjZ9SF6vrl-yu7i6ePtfXY1jQ0TnMfEQMomNi0YIdiYFFhuiSDaGFnkCaEFl5BaKgUjFkQiJjgnkhChibRyAsCG6Gx7d9k2LyvwnVo0q7YOLxXllHImUiYDNdpSQYH3LVi1bF2l214RrDaK1Uax-lUcAnIbeHUl9P_Q6iHLZn_Zb9UOhDc</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Nagalakshmamma, Vadabingi</creator><creator>Varalakshmi, Mavallur</creator><creator>Umapriya, Kollu</creator><creator>Venkataswamy, Mallepogu</creator><creator>Venkataramaiah, Chintha</creator><creator>Thyaga Raju, Kedam</creator><creator>Chalapathi, Ponne Venkata</creator><creator>NagaRaju, Chamarthi</creator><general>Wiley‐VCH Verlag GmbH & Co. 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| subjects | Antiinfectives and antibacterials antimicrobial activity Antimicrobial agents antioxidant activity Antioxidants bis‐(4‐aminophenyl) methane carbonyl chloridates Derivatives Hydrogen peroxide Infrared analysis Methane NMR Nuclear magnetic resonance Scavenging Sulfonamides sulfonyl chlorides Synthesis |
| title | Synthesis, antimicrobial and antioxidant activity of bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl) methane |
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