Mathematical and Numerical Models of the Central RegulatoryCircuit of the Morphogenesis System of Drosophila
The results are presented of mathematical and computer simulation of the functioning of the central regulatory circuit (CRC) which is the system integrator of the gene networks of morphogenesis of Drosophila mechanoreceptors. The main element of the CRC is represented by the complex of Achaete-Scute...
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| Veröffentlicht in: | Journal of applied and industrial mathematics 2020-01, Vol.14 (2), p.249-255 |
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| creator | Bukharina, T A Akinshin, A A Golubyatnikov, V P Furman, D P |
| description | The results are presented of mathematical and computer simulation of the functioning of the central regulatory circuit (CRC) which is the system integrator of the gene networks of morphogenesis of Drosophila mechanoreceptors. The main element of the CRC is represented by the complex of Achaete-Scute (AS-C) genes, the main genes of the mechanoreceptor morphogenesis. The content level of the proteins encoded by the AS-C genes is a determining factor for initiating the development of a mechanoreceptor. We carried out a comparative study of the CRC behavior under normal conditions and in the presence of mutational changes in the Achaete-Scute complex. The results of simulation are in good accord with the available biological data. |
| doi_str_mv | 10.1134/S1990478920020040 |
| format | Article |
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| subjects | Circuits Comparative studies Computer simulation Fruit flies Genes Insects Mechanoreceptors Morphogenesis Numerical models |
| title | Mathematical and Numerical Models of the Central RegulatoryCircuit of the Morphogenesis System of Drosophila |
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